Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Charbel Maroun‐Eid"'
Autor:
Roberto Lozano-Rodríguez, José Avendaño-Ortíz, Karla Montalbán-Hernández, Juan Carlos Ruiz-Rodríguez, Ricardo Ferrer, Alejandro Martín-Quirós, Charbel Maroun-Eid, Juan José González-López, Anna Fàbrega, Verónica Terrón-Arcos, María Gutiérrez-Fernández, Elisa Alonso-López, Carolina Cubillos-Zapata, María Fernández-Velasco, Rebeca Pérez de Diego, Pablo Pelegrin, Carlos García-Palenciano, Francisco J. Cueto, Carlos del Fresno, Eduardo López-Collazo
Publikováno v:
EBioMedicine, Vol 97, Iss , Pp 104841- (2023)
Summary: Background: Sepsis is associated with T-cell exhaustion, which significantly reduces patient outcomes. Therefore, targeting of immune checkpoints (ICs) is deemed necessary for effective sepsis management. Here, we evaluated the role of SIGLE
Externí odkaz:
https://doaj.org/article/3b43bccf46634fe7872802feee4227c8
Autor:
Alejandro Martín-Quirós, Charbel Maroun-Eid, José Avendaño-Ortiz, Roberto Lozano-Rodríguez, Jaime Valentín Quiroga, Verónica Terrón, Karla Montalbán-Hernández, Miguel A. García-Garrido, Elena Muñoz del Val, Álvaro del Balzo-Castillo, Carolina Rubio, Carolina Cubillos-Zapata, Luis A. Aguirre, Eduardo López-Collazo
Publikováno v:
Biomedicine Hub, Vol 6, Iss 1, Pp 48-58 (2021)
We report the disparate clinical progression of a couple infected by SARS-CoV-2 based on their immune checkpoint (IC) levels and immune cell distribution in blood from admission to exitus in patient 1 and from admission to discharge and recovery in p
Externí odkaz:
https://doaj.org/article/62279bd7943c4608b3fb09a67036b60d
Autor:
Clara Lorente-Sorolla, Antonio Garcia-Gomez, Francesc Català-Moll, Víctor Toledano, Laura Ciudad, José Avendaño-Ortiz, Charbel Maroun-Eid, Alejandro Martín-Quirós, Mónica Martínez-Gallo, Adolfo Ruiz-Sanmartín, Álvaro García del Campo, Ricard Ferrer-Roca, Juan Carlos Ruiz-Rodriguez, Damiana Álvarez-Errico, Eduardo López-Collazo, Esteban Ballestar
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-18 (2019)
Abstract Background Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic immune response to infection, associates with reduced responsiveness to subsequent infections. How such tolerance is acquired is not well understood bu
Externí odkaz:
https://doaj.org/article/0671a721e16c4fbeb6839d0e52d29349
The immune checkpoints storm in COVID‐19: Role as severity markers at emergency department admission
Autor:
José Avendaño‐Ortiz, Roberto Lozano‐Rodríguez, Alejandro Martín‐Quirós, Verónica Terrón, Charbel Maroun‐Eid, Karla Montalbán‐Hernández, Jaime Valentín‐Quiroga, Miguel Ángel García‐Garrido, Elena Muñoz del Val, Álvaro del Balzo‐Castillo, María Peinado, Laura Gómez, Carmen Herrero‐Benito, Carolina Rubio, José Carlos Casalvilla‐Dueñas, Paloma Gómez‐Campelo, Alejandro Pascual‐Iglesias, Carlos del Fresno, Luis A. Aguirre, Eduardo López‐Collazo
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 10, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/6ea00b38457044c6b62a8f09e045e3a5
Autor:
Roberto Lozano-Rodríguez, Verónica Terrón-Arcos, Raúl López, Juan Martín-Gutiérrez, Alejandro Martín-Quirós, Charbel Maroun-Eid, Elena Muñoz del Val, Carlos Cañada-Illana, Alejandro Pascual Iglesias, Jaime Valentín Quiroga, Karla Montalbán-Hernández, José Carlos Casalvilla-Dueñas, Miguel A. García-Garrido, Álvaro del Balzo-Castillo, María A. Peinado-Quesada, Laura Gómez-Lage, Carmen Herrero-Benito, Ray G. Butler, José Avendaño-Ortiz, Eduardo López-Collazo
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 12, p 3287 (2022)
Identifying patients’ immune system status has become critical to managing SARS-CoV-2 infection and avoiding the appearance of secondary infections during a hospital stay. Despite the high volume of research, robust severity and outcome markers are
Externí odkaz:
https://doaj.org/article/b5f01a7aef29462c846322154829147b
Autor:
José Avendaño-Ortiz, Roberto Lozano-Rodríguez, Alejandro Martín-Quirós, Charbel Maroun-Eid, Verónica Terrón, Jaime Valentín, Karla Montalbán-Hernández, Fátima Ruiz de la Bastida, Miguel A. García-Garrido, Carolina Cubillos-Zapata, Álvaro del Balzo-Castillo, Luis A. Aguirre, Eduardo López-Collazo
Publikováno v:
Heliyon, Vol 6, Iss 12, Pp e05635- (2020)
Increased cytokine levels, acute phase reactants and immune checkpoint expression changes have been described in patients with Coronavirus Disease 2019 (COVID-19). Here, we have reported a monocyte polarization towards a low HLA-DR and high PD-L1 exp
Externí odkaz:
https://doaj.org/article/04cbda20deb548639e400a6b2fa2aab2
Autor:
Jorge Gabriel Ruiz-Sánchez, Ivan J. Núñez-Gil, Martin Cuesta, Miguel A. Rubio, Charbel Maroun-Eid, Ramón Arroyo-Espliguero, Rodolfo Romero, Victor Manuel Becerra-Muñoz, Aitor Uribarri, Gisela Feltes, Daniela Trabattoni, María Molina, Marcos García Aguado, Martino Pepe, Enrico Cerrato, Emilio Alfonso, Alex Fernando Castro Mejía, Sergio Raposeiras Roubin, Luis Buzón, Elvira Bondia, Francisco Marin, Javier López Pais, Mohammad Abumayyaleh, Fabrizio D’Ascenzo, Elisa Rondano, Jia Huang, Cristina Fernandez-Perez, Carlos Macaya, Paz de Miguel Novoa, Alfonso L. Calle-Pascual, Vicente Estrada Perez, Isabelle Runkle, HOPE COVID-19 investigators
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Dysnatremia is associated with increased mortality in patients with community-acquired pneumonia. SARS-COV2 (Severe-acute-respiratory syndrome caused by Coronavirus-type 2) pneumonia can be fatal. The aim of this study was to ascertain whether admitt
Externí odkaz:
https://doaj.org/article/d4c5dd6136a44ab8a36b7f35820b140a
Autor:
José Avendaño-Ortiz, Charbel Maroun-Eid, Alejandro Martín-Quirós, Roberto Lozano-Rodríguez, Emilio Llanos-González, Víctor Toledano, Paloma Gómez-Campelo, Karla Montalbán-Hernández, César Carballo-Cardona, Luis A. Aguirre, Eduardo López-Collazo
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Sepsis is a pathology in which patients suffer from a proinflammatory response and a dysregulated immune response, including T cell exhaustion. A number of therapeutic strategies to treat human sepsis, which are different from antimicrobial and fluid
Externí odkaz:
https://doaj.org/article/539431cc14134c2597a692a9fe3250b3
Autor:
Charbel Maroun-Eid, Adriana Ortega-Hernández, Javier Modrego, María Abad-Cardiel, José Antonio García-Donaire, Leonardo Reinares, Nieves Martell-Claros, Dulcenombre Gómez-Garre
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190494 (2018)
Most hypertensive patients, despite a proper control of their cardiovascular risk factors, have cardiovascular complications, evidencing the importance of controlling and/or reversing target-organ damage. In this sense, endothelial dysfunction has be
Externí odkaz:
https://doaj.org/article/45b8ae94ab3b4e9c95ae306619dea827
Autor:
Enrique Álvarez, Víctor Toledano, Fernando Morilla, Enrique Hernández-Jiménez, Carolina Cubillos-Zapata, Aníbal Varela-Serrano, José Casas-Martín, José Avendaño-Ortiz, Luis A. Aguirre, Francisco Arnalich, Charbel Maroun-Eid, Alejandro Martín-Quirós, Manuel Quintana Díaz, Eduardo López-Collazo
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
System dynamics is a powerful tool that allows modeling of complex and highly networked systems such as those found in the human immune system. We have developed a model that reproduces how the exposure of human monocytes to lipopolysaccharides (LPSs
Externí odkaz:
https://doaj.org/article/0aff678f671f4b16a87ab233949121a6