Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Charanjit Rai Behl"'
Autor:
William I. Higuchi, Y. Seta, Charanjit Rai Behl, A.W. Malick, Abdel-Halim Ghanem, S. Borsadia
Publikováno v:
International Journal of Pharmaceutics. 81:89-99
For the purpose of obtaining a mechanistic understanding of drug transport through skin in the finite dose case, the permeation of radiolabeled hydrocortisone ( 3 H-HC) through hairless guinea-pig skin and layerwise retention in the skin have been st
Autor:
Y. Seta, William I. Higuchi, Charanjit Rai Behl, Vinod P. Shah, Abdel-Halim Ghanem, Gordon L. Flynn, S. Borsadia
Publikováno v:
Skin Pharmacology and Physiology. 5:129-145
In this paper, an attempt is made to find functional definitions of bioavailability and bioequivalence for topical products and to examine critical factors that influence topical bioavailability and bioequivalence. A physical model approach for quant
Autor:
William I. Higuchi, Michael Barrett, Kenneth A. Walters, Charanjit Rai Behl, Norman F.H. Ho, Olivia G. Gatmaitan, Gordon L. Flynn, Carl L. Pierson, Nancy Harper, Tamie Kurihara
Publikováno v:
Journal of Pharmaceutical Sciences. 71:229-234
The influence of hydration on the permeability of stripped and scalded skins of hairless mice was investigated in vitro using water and n-alkanols as test permeants. Irrespective of pretreatment, the permeation rates of water, methanol, and ethanol w
Publikováno v:
Journal of Pharmaceutical Sciences. 72:79-82
The effect of protracted aqueous contact of rat skin on its permeability to methanol, n-butanol, and n-hexanol was investigated. With the aid of small diffusion cells, sets of intermittent permeation experiments, each approximately 7 hr in duration,
Publikováno v:
Journal of Pharmaceutical Sciences. 78:370-375
Three factors are of primary importance in determining the iontophoretic flux of a charged solute: the electrochemical potential gradient across the skin, an increase in skin permeability to passive transport due to iontophoresis (loosely defined as
Autor:
Gordon L. Flynn, Carl L. Pierson, Norman F.H. Ho, William I. Higuchi, Edward E. Linn, Charanjit Rai Behl
Publikováno v:
Journal of Pharmaceutical Sciences. 72:397-400
The safe antiseptic use of phenol over the burn-traumatized surface depends on knowledge of how the systemic accumulation of phenol is affected by burn processes. To gain insight into the underlying permeation phenomenon, the diffusion of phenol and
Autor:
Gordon L. Flynn, Michael Barrett, Charanjit Rai Behl, Carl L. Pierson, Norman F.H. Ho, Edwards E. Linn, Tamie Kurihara, William I. Higuchi, Kenneth A. Walters, Zenaub Mohamed
Publikováno v:
Burns. 7:389-399
Dry heat burns of incrementally increased duration (15–960 seconds) have been administered to freshly sacrificed mice with a thermostated branding iron maintained at 60°C. The association between extent of burn damage (shallow to deep tissue damag
Autor:
Norman F.H. Ho, Nancy Harper, William I. Higuchi, Carl L. Pierson, Ward W. Smith, Gordon L. Flynn, Charanjit Rai Behl, Tamie Kurihara
Publikováno v:
Journal of Investigative Dermatology. 75(4):346-352
A method to study the influence of hydration on skin permeability where the skin is immersed in saline for up to 30 hr and under circumstances where a steady state rate of permeation can be established in several minutes is indicated. These circumsta
Publikováno v:
Journal of Pharmaceutical Sciences. 70:835-837
Autor:
Ward W. Smith, Tamie Kurihara, Gordon L. Flynn, William I. Higuchi, Olivia G. Gatmaitan, Norman F.H. Ho, Carl L. Pierson, Charanjit Rai Behl
Publikováno v:
The Journal of investigative dermatology. 75(4)
Freshly sacrificed hairless mice were burned dorsally by direct contact with 60 degrees C water for periods ranging from 15 seconds to 8 min. Wounds ranging in degree from superficial epidermis damage to injury penetrating well into subcutaneous musc