Zobrazeno 1 - 1
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pro vyhledávání: '"Charamanna Belliappa"'
Autor:
Ramulu Poddutoori, Kimberly Aardalen, Kiran Aithal, Sanjeev Surendranath Barahagar, Charamanna Belliappa, Mark Bock, Shekar Chelur, Andrea Gerken, Sreevalsam Gopinath, Bjoern Gruenenfelder, Michael Kiffe, Maithreyi Krishnaswami, John Langowski, Sudharshan Madapa, Kishore Narayanan, Chetan Pandit, Sunil Kumar Panigrahi, Mark Perrone, Ravi Kumar Potakamuri, Murali Ramachandra, Anuradha Ramanathan, Rita Ramos, Emine Sager, Susanta Samajdar, Hosahalli S. Subramanya, Devaraja Seethappa Thimmasandra, Eleni Venetsanakos, Henrik Möbitz
Publikováno v:
Journal of Medicinal Chemistry. 65:4350-4366
Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from a HTS hit, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7df3980bf0fc9797eb2d0401e08b1d0f
https://doi.org/10.1021/acs.jmedchem.1c02192
https://doi.org/10.1021/acs.jmedchem.1c02192
