Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Charalampos G, Kalodimos"'
Autor:
Qiong Xing, Ke Shi, Athina Portaliou, Paolo Rossi, Anastassios Economou, Charalampos G. Kalodimos
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Bacterial flagella are composed of proteins secreted by a type III secretion system (T3SS), which requires the action of dedicated chaperones. Here, Xing et al. report the structures of two ternary complexes among flagellar chaperones, flagellar prot
Externí odkaz:
https://doaj.org/article/3301e93fb2734ce796a0783e8b545527
Publikováno v:
eLife, Vol 7 (2018)
Molecular chaperones alter the folding properties of cellular proteins via mechanisms that are not well understood. Here, we show that Trigger Factor (TF), an ATP-independent chaperone, exerts strikingly contrasting effects on the folding of non-nati
Externí odkaz:
https://doaj.org/article/280dceb6efa84fcbbf27658a7f42a616
Autor:
Yajun Jiang, Charalampos G Kalodimos
Publikováno v:
eLife, Vol 7 (2018)
NMR studies settle part of a long-standing debate about the mechanism used by the Hsp70 chaperone to recognize substrates.
Externí odkaz:
https://doaj.org/article/d15b360dd4ea4d13899d5e2cef342713
Publikováno v:
Journal of Biomolecular NMR. 75:133-142
A unique aspect of NMR is its capacity to provide integrated insight into both the structure and intrinsic dynamics of biomolecules. Chemical exchange phenomena that often serve as probes of dynamic processes in biological macromolecules can be quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6190616831d6367b48b06addb3a469c
https://doi.org/10.1007/s10858-021-00362-0
https://doi.org/10.1007/s10858-021-00362-0
Autor:
Li Chen, Xuanjun Ai, Athina G. Portaliou, Conceicao A.S.A. Minetti, David P. Remeta, Anastassios Economou, Charalampos G. Kalodimos
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 709-715 (2013)
The targeting of type III secretion (TTS) proteins at the injectisome is an important process in bacterial virulence. Nevertheless, how the injectisome specifically recognizes TTS substrates among all bacterial proteins is unknown. A TTS peripheral m
Externí odkaz:
https://doaj.org/article/5746b875158e4df590f9d0789ac7dc46
Publikováno v:
Structure
Methyl-TROSY spectroscopy has extended the reach of solution-state NMR to supra-molecular machineries over 100 kDa in size. Methyl groups are ideal probes for studying structure, dynamics, and protein-protein interactions in quasi-physiological condi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce51e97130e31210086ff9876db1369
https://europepmc.org/articles/PMC8741727/
https://europepmc.org/articles/PMC8741727/
Publikováno v:
J Mol Biol
Imatinib is an ATP-competitive inhibitor of Bcr-Abl kinase and the first drug approved for chronic myelogenous leukemia (CML) treatment. Here we show that imatinib binds to a secondary, allosteric site located in the myristoyl pocket of Abl to functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f889221c982e501df73696024f00b03
https://europepmc.org/articles/PMC8752476/
https://europepmc.org/articles/PMC8752476/
Autor:
Tao Xie, Charalampos G Kalodimos
Publikováno v:
eLife, Vol 4 (2015)
A combination of NMR techniques is able to explore the structure of short-lived protein conformations.
Externí odkaz:
https://doaj.org/article/12c480a6a2cc45f59f3c0ac87ad7cd0b
Autor:
Munia Sowaileh, Jitendra Das, Charalampos G. Kalodimos, Yixin Cui, Zoran Rankovic, Brandon Young, P. Jake Slavish, Paolo Rossi
Publikováno v:
Org Lett
Isotopically labeled amino acids are widely used to study the structure and dynamics of proteins by NMR. Herein we describe a facile, gram-scale synthesis of compounds 1b and 2b under standard laboratory conditions from the common intermediate 7. 2b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611974ebd6f55c1cbc204b49681f5f14
https://europepmc.org/articles/PMC8884888/
https://europepmc.org/articles/PMC8884888/
Autor:
Munia Sowaileh, Jyotidarsini Mohanty, Amanda Nourse, Alexander G. Myasnikov, Darcie J. Miller, Irit Lax, Joseph Schlessinger, Paolo Rossi, Andrey V. Reshetnyak, Charalampos G. Kalodimos
Publikováno v:
Nature
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that regulates important functions in the central nervous system1,2. The ALK gene is a hotspot for chromosomal translocation events that result in several fusion proteins that cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5540257baebb2f6c0b024dd3b4b7f003
https://pubmed.ncbi.nlm.nih.gov/34819673
https://pubmed.ncbi.nlm.nih.gov/34819673