Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Charalampos, Kapsalis"'
Autor:
Charalampos Kapsalis, Bolin Wang, Hassane El Mkami, Samantha J. Pitt, Jason R. Schnell, Terry K. Smith, Jonathan D. Lippiat, Bela E. Bode, Christos Pliotas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
How mechanosensitive ion channels, such as MscL, are activated by lipids and physical properties of the membrane remains unclear. Here authors use PELDOR/DEER spectroscopy and identify a single site which generated an allosteric structural response i
Externí odkaz:
https://doaj.org/article/a7be892017b649e08e44a9f92049a42a
Autor:
Eleni, Vasilopoulou, Artemis, Giannakopoulou, Charalampos, Kapsalis, Myrsini, Michou, Aristeidis, Michoglou-Sergiou, Fragiskos N, Kolisis, Georgios, Skretas
Publikováno v:
ACS synthetic biology. 11(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0feb9cf13a154c7b11651a563d60f189
https://pubmed.ncbi.nlm.nih.gov/35922033
https://pubmed.ncbi.nlm.nih.gov/35922033
Autor:
Eleni Vasilopoulou, Artemis Giannakopoulou, Charalampos Kapsalis, Myrsini Michou, Aristeidis Michoglou-Sergiou, Fragiskos N. Kolisis, Georgios Skretas
Publikováno v:
ACS Synthetic Biology. 11:2599-2609
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cae81fd189e2644982b5d80dd7ad1e5
https://doi.org/10.1021/acssynbio.1c00598
https://doi.org/10.1021/acssynbio.1c00598
In-Lipid Structure of Pressure-Sensitive Domains Hints Mechanosensitive Channel Functional Diversity
Publikováno v:
Biophysical Journal
Kapsalis, C, Ma, Y, Bode, B E & Pliotas, C 2020, ' In-lipid structure of pressure sensitive domains hints mechanosensitive channel functional diversity ', Biophysical Journal, vol. 119, no. 2, pp. 448-459 . https://doi.org/10.1016/j.bpj.2020.06.012
Kapsalis, C, Ma, Y, Bode, B E & Pliotas, C 2020, ' In-lipid structure of pressure sensitive domains hints mechanosensitive channel functional diversity ', Biophysical Journal, vol. 119, no. 2, pp. 448-459 . https://doi.org/10.1016/j.bpj.2020.06.012
This project was supported by a BBSRC grant (BB/S018069/1) to C.P., who was supported by the Royal Society of Edinburgh, Tenovus (T15/41) and Carnegie Trust (OS000256), at the initial stages of this project. Further C.P. acknowledges support from the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffacbb996ec44ca2959607f47f95a2b5
http://europepmc.org/articles/PMC7376121
http://europepmc.org/articles/PMC7376121
Autor:
Jonathan D. Lippiat, Charalampos Kapsalis, Terry K. Smith, Samantha J. Pitt, Christos Pliotas, Bela E. Bode, Jason R. Schnell, Bolin Wang, Hassane El Mkami
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Kapsalis, C, Wang, B, Mkami, H E, Pitt, S J, Schnell, J R, Smith, T K, Lippiat, J D, Bode, B E & Pliotas, C 2019, ' Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets ', Nature Communications, vol. 10, 4619, pp. 1-14 . https://doi.org/10.1038/s41467-019-12591-x
Nature Communications
Kapsalis, C, Wang, B, Mkami, H E, Pitt, S J, Schnell, J R, Smith, T K, Lippiat, J D, Bode, B E & Pliotas, C 2019, ' Allosteric activation of an ion channel triggered by modification of mechanosensitive nano-pockets ', Nature Communications, vol. 10, 4619, pp. 1-14 . https://doi.org/10.1038/s41467-019-12591-x
Lipid availability within transmembrane nano-pockets of ion channels is linked with mechanosensation. However, the effect of hindering lipid-chain penetration into nano-pockets on channel structure has not been demonstrated. Here we identify nano-poc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4f45815654ff1d3fa5745d249d8fc0
http://link.springer.com/article/10.1038/s41467-019-12591-x
http://link.springer.com/article/10.1038/s41467-019-12591-x
Autor:
Frank Sobott, Benjamin J. Lane, Antonio N. Calabrese, Bolin Wang, Hassane El Mkami, Charalampos Kapsalis, James R. Ault, Antreas C. Kalli, Christos Pliotas
The MscL channel gates in response to membrane tension changes to allow the exchange of molecules through its pore. Lipid removal from transmembrane pockets leads to a MscL response. However, it is unknown whether there is correlation between the ten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5577b9f9285bfbd02243069f7d73db2
https://doi.org/10.1101/2021.04.01.438050
https://doi.org/10.1101/2021.04.01.438050
Publikováno v:
ACS synthetic biology. 8(7)
Membrane proteins (MPs) execute a wide variety of critical biological functions in all living organisms and constitute approximately half of current targets for drug discovery. As in the case of soluble proteins, the bacterium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d28a04655e7df9114652a42460893b8b
https://pubmed.ncbi.nlm.nih.gov/31243979
https://pubmed.ncbi.nlm.nih.gov/31243979
Funding: CP would like to acknowledge the Royal Society of Edinburgh, Tenovus (T15/41), Carnegie Trust (OS000256) grant awards and the School of Biology of the University of St Andrews for a PhD studentship to CK. Membrane proteins (MPs) execute a wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c04b74fa7109422a422660cdd18c4fa9
https://hdl.handle.net/10023/20051
https://hdl.handle.net/10023/20051