A scalable platform for the development of cell-type-specific viral drivers

Autor: Sinisa Hrvatin, Christopher P Tzeng, M Aurel Nagy, Hume Stroud, Charalampia Koutsioumpa, Oren F Wilcox, Elena G Assad, Jonathan Green, Christopher D Harvey, Eric C Griffith, Michael E Greenberg

Publikováno v: eLife, Vol 8 (2019)

Enhancers are the primary DNA regulatory elements that confer cell type specificity of gene expression. Recent studies characterizing individual enhancers have revealed their potential to direct heterologous gene expression in a highly cell-type-spec

Externí odkaz: https://doaj.org/article/9e25154002544c1190234773b67776a3

Mechanoreceptor synapses in the brainstem shape the central representation of touch

Autor: David D. Ginty, Charalampia Koutsioumpa, Celine Santiago, Sophia Renauld, Alan J. Emanuel, Ling Bai, Alexandra R. Magee, Nusrat Africawala, Erica L. Huey, Jennifer T. Hong, Christopher D. Harvey, Ilayda Alkislar, Yang Zheng, Brendan P. Lehnert

Mammals use glabrous (hairless) skin of their hands and feet to navigate and manipulate their environment. Cortical maps of the body surface across species contain disproportionately large numbers of neurons dedicated to glabrous skin sensation, pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::813db0b743cc384a8e6b9a5632d6db87
https://doi.org/10.1101/2021.02.02.429463

Global assessment of C-reactive protein and health-related outcomes: an umbrella review of evidence from observational studies and Mendelian randomization studies

Autor: Charalampia Koutsioumpa, Ioanna Tzoulaki, Nikolaos Kretsavos, Grace Monori, Sofia Cividini, Georgios Markozannes, Konstantinos K. Tsilidis, Evropi Theodoratou, John P. A. Ioannidis, Dipender Gill

Publikováno v: European Journal of Epidemiology
Markozannes, G, Koutsioumpa, C, Cividini, S, Monori, G, Tsilidis, K K, Kretsavos, N, Theodoratou, E, Gill, D, Ioannidis, J P & Tzoulaki, I 2020, ' Global assessment of C-reactive protein and health-related outcomes : an umbrella review of evidence from observational studies and Mendelian randomization studies ', European Journal of Epidemiology . https://doi.org/10.1007/s10654-020-00681-w

C-reactive protein (CRP) has been studied extensively for association with a large number of non-infectious diseases and outcomes. We aimed to evaluate the breadth and validity of associations between CRP and non-infectious, chronic health outcomes a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171ec512f42ecdb656fc2b4a3c061ae6
https://openaccess.sgul.ac.uk/id/eprint/112772/1/Markozannes2020_Article_GlobalAssessmentOfC-reactivePr.pdf

Converging Mechanisms of p53 Activation Drive Motor Neuron Degeneration in Spinal Muscular Atrophy

Autor: Joseph E. Rabinowitz, Christopher E. Henderson, Christian M. Simon, Livio Pellizzoni, Ya Dai, Joshua I. Chalif, John G. Pagiazitis, Charalampia Koutsioumpa, Meaghan Van Alstyne, George Z. Mentis, Xiaojian Wang

Publikováno v: Cell Reports, Vol 21, Iss 13, Pp 3767-3780 (2017)

Summary The hallmark of spinal muscular atrophy (SMA), an inherited disease caused by ubiquitous deficiency in the SMN protein, is the selective degeneration of subsets of spinal motor neurons. Here, we show that cell-autonomous activation of p53 occ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f460f1d83f95ffe5e66f88776af9d2d
http://www.sciencedirect.com/science/article/pii/S2211124717317990

PESCA: A scalable platform for the development of cell-type-specific viral drivers

Autor: Hume Stroud, Christopher P. Tzeng, Jeremy B. Green, Elena G. Assad, Christopher D. Harvey, Michael E. Greenberg, Nagy Ma, Oren F Wilcox, Charalampia Koutsioumpa, Eric C. Griffith, Sinisa Hrvatin

Enhancers are the primary DNA regulatory elements that confer cell type specificity of gene expression. Recent studies characterizing individual enhancers have revealed their potential to direct heterologous gene expression in a highly cell-type-spec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27fcea1ad394539eaf9565b64e2cdd2