Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Chara Litou"'
Autor:
Laura J. Henze, Christos Reppas, Jennifer B. Dressman, Marina Statelova, Chara Litou, Christina Pentafragka, Patrick J O'Dwyer, Karl J. Box, Brendan T. Griffin, Maria Vertzoni
Publikováno v:
Journal of Pharmacy and Pharmacology. 73:437-446
ObjectivesTo summarise key contributions of the Pharmaceutical Education and Research with Regulatory Links (PEARRL) project (2016–2020) to the optimisation of existing and the development of new biopharmaceutics tools for evaluating the in vivo pe
Autor:
Jennifer B. Dressman, Karl J. Box, David B. Turner, Edmund Kostewicz, René Holm, Martin Kuentz, Chara Litou, Nico Holmstock, Jens Ceulemans
Publikováno v:
European Journal of Pharmaceutical Sciences
Introduction : In the development of bio-enabling formulations, innovative in vivo predictive tools to understand and predict the in vivo performance of such formulations are needed. Etravirine, a non-nucleoside reverse transcriptase inhibitor, is cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1dd04f1a01df8b73f4a01e8f7595685
http://publikationen.ub.uni-frankfurt.de/files/53224/Etravirine_research_paper_local_repository.pdf
http://publikationen.ub.uni-frankfurt.de/files/53224/Etravirine_research_paper_local_repository.pdf
Publikováno v:
Pharmaceutical Research
Purpose: The design of biorelevant conditions for in vitro evaluation of orally administered drug products is contingent on obtaining accurate values for physiologically relevant parameters such as pH, buffer capacity and bile salt concentrations in
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 115:94-101
Purpose To propose media for simulating the intragastric environment under reduced gastric acid secretion in the fasted state at three levels of simulation of the gastric environment and evaluate their usefulness in evaluating the intragastric dissol
Autor:
Chara Litou, Karl J. Box, David B. Turner, Nikunjkumar Patel, Jennifer B. Dressman, Edmund Kostewicz, Martin Kuentz
Publikováno v:
European Journal of Pharmaceutical Sciences
Introduction: When developing bio-enabling formulations, innovative tools are required to understand and predict in vivo performance and may facilitate approval by regulatory authorities. EMEND® is an example of such a formulation, in which the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d06ca46b1d63a704192ba46b96039a
http://publikationen.ub.uni-frankfurt.de/files/50918/Aprepitant_research_paper_submission_version.pdf
http://publikationen.ub.uni-frankfurt.de/files/50918/Aprepitant_research_paper_submission_version.pdf
Autor:
Angela Effinger, Chara Litou, Nikoletta Fotaki, Edmund Kostewicz, Jennifer B. Dressman, Karl J. Box
Publikováno v:
Litou, C, Effinger, A, Kostewicz, E S, Box, K J, Fotaki, N & Dressman, J B 2019, ' Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs : A PEARRL Review ', Pharmacy and Pharmacology Communications, vol. 71, no. 4, pp. 643-673 . https://doi.org/10.1111/jphp.12983
Journal of Pharmacy and Pharmacology
Journal of Pharmacy and Pharmacology
ObjectivesDrugs used to treat gastrointestinal diseases (GI drugs) are widely used either as prescription or over-the-counter (OTC) medications and belong to both the 10 most prescribed and 10 most sold OTC medications worldwide. The objective of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174eb1aa4f0f0928dc74882b42866751
https://purehost.bath.ac.uk/ws/files/185394836/PK_interactions_co_medication_GI_diesease_PEARRL_review_Dr_N_Fotaki.pdf
https://purehost.bath.ac.uk/ws/files/185394836/PK_interactions_co_medication_GI_diesease_PEARRL_review_Dr_N_Fotaki.pdf
Autor:
Chara Litou, Christos Reppas, Karl J. Box, Jennifer B. Dressman, Patrick J O'Dwyer, Martin Kuentz, Edmund Kostewicz
Publikováno v:
Journal of Pharmacy and Pharmacology
Objectives Drug precipitation in vivo poses a significant challenge for the pharmaceutical industry. During the drug development process, the impact of drug supersaturation or precipitation on the in vivo behaviour of drug products is evaluated with
Autor:
Filippos Kesisoglou, Constantinos Goumas, Christos Reppas, Wei Xu, Chara Litou, Vassilis G. S. Vasdekis, Maria Vertzoni
Publikováno v:
Pharmaceutical research. 33(6)
Evaluate the impact of reduced gastric acid secretion after administration of two acid-reducing agents on the physicochemical characteristics of contents of upper gastrointestinal lumen of fasted adults. Eight healthy male adults, fasted from food fo