Výsledky vyhledávání - "Char-Chang Lai"

Productive Interaction between Transmembrane Mutants of the Bovine Papillomavirus E5 Protein and the Platelet-Derived Growth Factor β Receptor

Autor: Anne P. B. Edwards, Daniel DiMaio, Char-Chang Lai

Publikováno v: Journal of Virology. 79:1924-1929

The bovine papillomavirus E5 protein is a 44-amino-acid transmembrane protein that transforms cells by binding to the transmembrane region of the cellular platelet-derived growth factor (PDGF) β receptor, resulting in sustained receptor signaling. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7f61c4efaf1b7bb1eea60bb38c8337
https://doi.org/10.1128/jvi.79.3.1924-1929.2005

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Bovine Papillomavirus E5 Protein Induces the Formation of Signal Transduction Complexes Containing Dimeric Activated Platelet-derived Growth Factor β Receptor and Associated Signaling Proteins

Autor: Char-Chang Lai, Daniel DiMaio, Carl Henningson

Publikováno v: Journal of Biological Chemistry. 275:9832-9840

The bovine papillomavirus E5 protein binds to the cellular platelet-derived growth factor (PDGF) beta receptor, resulting in constitutive activation of the receptor and cell growth transformation. By subjecting extracts from E5-transformed or PDGF-tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1587c9fa17a1896ce26ca13dc3301e9
https://doi.org/10.1074/jbc.275.13.9832

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Bovine papillomavirus E5 protein induces oligomerization and trans-phosphorylation of the platelet-derived growth factor β receptor

Autor: Carl Henningson, Char-Chang Lai, Daniel DiMaio

Publikováno v: Proceedings of the National Academy of Sciences. 95:15241-15246

The bovine papillomavirus E5 protein is a 44-aa transmembrane protein that forms a stable complex with the cellular platelet-derived growth factor (PDGF) β receptor and induces constitutive tyrosine phosphorylation and activation of the receptor, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7dbe417a9db34c380b00a9da5472df
https://doi.org/10.1073/pnas.95.26.15241

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Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins

Autor: Scott Powers, Char-Chang Lai, D. Broek, M. Boguski

Publikováno v: Molecular and Cellular Biology. 13:1345-1352

The Saccharomyces cerevisiae CDC25 gene and closely homologous genes in other eukaryotes encode guanine nucleotide exchange factors for Ras proteins. We have determined the minimal region of the budding yeast CDC25 gene capable of activity in vivo. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2514fa15ddd22cfee4ba2c232bb1293c
https://doi.org/10.1128/mcb.13.3.1345

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Expression of DNA polymerase {beta} cancer-associated variants in mouse cells results in cellular transformation

Autor: Shibani Dalal, Char-Chang Lai, Daniel DiMaio, Joann B. Sweasy, Ka-Wai Sun, Daniela Starcevic, Tieming Lang

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 102(40)

Thirty percent of the 189 tumors studied to date express DNA polymerase β variants. One of these variants was identified in a prostate carcinoma and is altered from isoleucine to methionine at position 260, within the hydrophobic hinge region of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7efc706868632a7a11d547bbb9ffffd0
https://pubmed.ncbi.nlm.nih.gov/16179390

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Crystal structures of murine MHC Class I H-2 D(b) and K(b) molecules in complex with CTL epitopes from influenza A virus: implications for TCR repertoire selection and immunodominance

Autor: Jia-huai Wang, Rob Meijers, Ellis L. Reinherz, Yuting Yang, Jin-huan Liu, Char-Chang Lai, Weimin Zhong

Publikováno v: Journal of molecular biology. 345(5)

Cytotoxic T lymphocyte (CTL) responses against influenza A virus in C57BL/6 mice are dominated by a small number of viral peptides among many that are capable of binding to major histocompatibility complex (MHC) class I molecules. The basis of this l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339d9d6313eb3d0542311ce0267adc7e
https://pubmed.ncbi.nlm.nih.gov/15644207

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Disparate peptide-dependent thymic selection outcomes in beta2M-deficient mice versus TAP-1-deficient mice: implications for repertoire formation

Autor: Yuting Yang, Jin-huan Liu, Ellis L. Reinherz, Emilio Parisini, Jia-huai Wang, Maki Touma, Char-Chang Lai, Tetsuro Sasada, Linda K. Clayton

Publikováno v: European journal of immunology. 33(2)

Fetal thymic organ cultures of N15-transgenic RAG-2-/- H-2b mice on normal, beta-2 microglobulin (beta2M)-/- or transporter associated with antigen processing (rAP-1)-/- MHCl-deficient backgrounds were used to examine differentiation of thymocytes be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a43571b3841b7d2e96c59f59d564a5
https://pubmed.ncbi.nlm.nih.gov/12645934

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Genome-wide characterization of a viral cytotoxic T lymphocyte epitope repertoire

Autor: Ellis L. Reinherz, Pedro A. Reche, Char-Chang Lai, Bruce B. Reinhold, Weimin Zhong

Publikováno v: E-Prints Complutense. Archivo Institucional de la UCM
instname
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid

A genome-wide search using major histocompatibility complex (MHC) class I binding and proteosome cleavage site algorithms identified 101 influenza A PR8 virus-derived peptides as potential epitopes for CD8+ T cell recognition in the H-2b mouse. Cytok

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https://eprints.ucm.es/id/eprint/9337/1/20.Zhang_Reche_etal_JBC_2003.pdf

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Definition of an inhibitory juxtamembrane WW-like domain in the platelet-derived growth factor beta receptor

Autor: Omar Bakht, Daniel DiMaio, Steven O. Smith, Yue Luo, Char-Chang Lai, Pablo M. Irusta

Publikováno v: The Journal of biological chemistry. 277(41)

A variety of tumors contain activating mutations in the cytoplasmic juxtamembrane domain of the type III family of receptor-tyrosine kinases, and some constructed mutations in this domain induce ligand-independent receptor activation. To explore the

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https://pubmed.ncbi.nlm.nih.gov/12181311

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The platelet-derived growth factor beta receptor as a target of the bovine papillomavirus E5 protein

Autor: Dawn Mattoon, Char-Chang Lai, Daniel DiMaio

Publikováno v: Cytokinegrowth factor reviews. 11(4)

The 44-amino acid E5 protein of bovine papillomavirus is a homo-dimeric, transmembrane protein that transforms cells by activating the platelet-derived growth factor s receptor in a ligand-independent fashion. The E5 protein induces receptor activati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde5f767713d39e9be2c9691aec321ef
https://pubmed.ncbi.nlm.nih.gov/10959076

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