Výsledky vyhledávání - "Chaperone Gene"

HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response

Autor: Akira Nakai, Mitsuaki Fujimoto, Mariko Okada, Pratibha Srivastava, Ryosuke Takii, Ai Kurashima, Arpit Katiyar, Ke Tan

Publikováno v: FEBS Open Bio, Vol 10, Iss 6, Pp 1135-1148 (2020)
FEBS Open Bio

The mitochondrial unfolded protein response (UPRmt) is characterized by the transcriptional induction of mitochondrial chaperone and protease genes in response to impaired mitochondrial proteostasis and is regulated by ATF5 and CHOP in mammalian cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f855880065c12933a4ff11e4d1eb87
https://doaj.org/article/ed47cad0ab0a4a8099f07a67a712671f

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HSF1 phase transition mediates stress adaptation and cell fate decisions

Autor: Carmen G Li, Clarence Yapp, Luke Whitesell, Susan Lindquist, Kristopher A. Sarosiek, Sandro Santagata, Rumana Rashid, Peter K. Sorger, Giorgio Gaglia, Gaurav N. Joshi

Publikováno v: Nature cell biology

Under proteotoxic stress, some cells survive whereas others die. The mechanisms governing this heterogeneity in cell fate remain unknown. Here we report that condensation and phase transition of heat-shock factor 1 (HSF1), a transcriptional regulator

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fdfd45a309fa750b6eaed115ab93662
http://europepmc.org/articles/PMC7135912

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Akademický článek

Pten Null Prostate Tumorigenesis and AKT Activation Are Blocked by Targeted Knockout of ER Chaperone GRP78/BiP in Prostate Epithelium

Autor: Fu, Yong, Wey, Shiuan, Wang, Miao, Ye, Risheng, Liao, Chun-Peng, Roy-Burman, Pradip, Lee, Amy S.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2008 Dec 01. 105(49), 19444-19449.

Externí odkaz: https://www.jstor.org/stable/25465663

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Heterologous expression of a putative ClpC chaperone gene leads to induction of a host metabolite

Autor: Jana Braesel, Alessandra S. Eustáquio

Publikováno v: J Braz Chem Soc
Journal of the Brazilian Chemical Society, Volume: 30, Issue: 3, Pages: 499-508, Published: MAR 2019
Journal of the Brazilian Chemical Society v.30 n.3 2019
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ

Genome mining provides exciting opportunities for the discovery of natural products. However, in contrast to traditional bioassay-guided approaches, challenges of genome mining include poor or no expression of biosynthetic gene clusters (BGCs). Addit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225a73f8a519ade59cb2411c90edb473
https://pubmed.ncbi.nlm.nih.gov/33859447

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Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease

Autor: Federica Sandrelli, Elisa Greggio, Mariano Beltramini, Marco Bisaglia, Luigi Bubacco, Alice Biosa

Publikováno v: Neurobiology of Disease, Vol 108, Iss, Pp 65-72 (2017)

Several mutations in the gene coding for DJ-1 have been associated with early onset forms of parkinsonism. In spite of the massive effort spent by the scientific community in understanding the physiological role of DJ-1, a consensus on what DJ-1 actu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c02ef3f4672555f24f7a7d9bb0ef64
https://doi.org/10.1016/j.nbd.2017.08.005

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Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis

Autor: Eric Solis, Dexter X. Jin, Jai P. Pandey, Vladimir Denic, Xu Zheng, Piyush Gupta, David Pincus, Edoardo M. Airoldi

Publikováno v: PMC

Despite its eponymous association with the heat shock response, yeast heat shock factor 1 (Hsf1) is essential even at low temperatures. Here we show that engineered nuclear export of Hsf1 results in cytotoxicity associated with massive protein aggreg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464d2e2353416b04e8221908b1367ed5
https://doi.org/10.1016/j.molcel.2016.05.014

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Yeast molecular chaperone gene SSB2 is involved in the endoplasmic reticulum stress response

Autor: Xiao-Shan Hong, Tao Zhou, Wei Zhao, Hong-Jing Cui, Xinguang Liu, Kun-Pei Qiu

Publikováno v: Antonie van Leeuwenhoek. 112(4)

The Saccharomyces cerevisiae chaperone gene SSB2 belongs to the Hsp70 family. Unlike other HSP70 genes, SSB2 gene expression is reduced after heat shock. It has been reported that Ssb2p can be cross-linked to ribosome-bound nascent polypeptide chains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c1a4eaaf9227de81ff2a1a157a43df
https://pubmed.ncbi.nlm.nih.gov/30382435

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Hepatocyte-like cells reveal novel role of SerpinA1 in transthyretin amyloidosis

Autor: Lutz Fleischhauer, Andree Zibert, Vanessa Sandfort, Christoph Niemietz, S Guttmann, Hartmut Schmidt

Publikováno v: Journal of Cell Science.

Transthyretin (TTR)-related familial amyloid polyneuropathy (ATTR) results from aggregation and extracellular disposition of misfolded TTR variants. Growing evidence suggests the importance of hepatic chaperones for modulation of pathogenesis. We too

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9350babaa89761eaf73296339bc97d16
https://doi.org/10.1242/jcs.219824

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Olfactory experience primes the heat shock transcription factor HSF-1 to enhance the expression of molecular chaperones in

Autor: Felicia K. Ooi, Veena Prahlad

Publikováno v: Science signaling. 10(501)

Learning, a process by which animals modify their behavior as a result of experience, enables organisms to synthesize information from their surroundings to acquire resources and avoid danger. We showed that a previous encounter with only the odor of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f26382b8e4ceab03b410387d319704
https://pubmed.ncbi.nlm.nih.gov/29042483

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