P2-11-04: TMEPAI Is a Feedback Regulator of TGF-b Signaling during Breast Cancer Progression

Autor: Prajjal K. Singha, La Chapa Jj De, Srilakshmi Pandeswara, Pothana Saikumar, Manjeri A. Venkatachalam

Publikováno v: Cancer Research. 71:P2-11

Background: Despite lack of hormone receptors (ER/PR) and HER2, many triple negative breast cancers (TNBC) depend on transforming growth factor beta (TGF-β) signaling activity for late growth and metastasis. Thus TGF-β signaling is a major potentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75fa748d20cd64233cea321d81ba189c
https://doi.org/10.1158/0008-5472.sabcs11-p2-11-04

PCSK9 Inhibition in Patients After Heart Transplantation: a Retrospective Review and Literature Analysis.

Autor: Chapa JJ; Indiana University School of Medicine, Department of Medicine, 340 West 10th Street, Indianapolis, IN, 46202, USA. jjchapa@iu.edu., McCollum JC; Indiana University School of Medicine, Department of Medicine, 340 West 10th Street, Indianapolis, IN, 46202, USA., Bisono JQ; Indiana University School of Medicine, Department of Medicine, 340 West 10th Street, Indianapolis, IN, 46202, USA., Prakash RS; American University of Antigua College of Medicine, Jabberwock Beach Road, Coolidge, Osbourn, Antigua and Barbuda., Guglin ME; Indiana University School of Medicine, Department of Medicine, 340 West 10th Street, Indianapolis, IN, 46202, USA., Rao RA; Indiana University School of Medicine, Department of Medicine, 340 West 10th Street, Indianapolis, IN, 46202, USA.

Publikováno v: Current heart failure reports [Curr Heart Fail Rep] 2023 Jun; Vol. 20 (3), pp. 168-178. Date of Electronic Publication: 2023 May 08.

Inhibition of Ca ²⁺ entry by capsazepine analog CIDD-99 prevents oral squamous carcinoma cell proliferation.

Autor: Sun Y; Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States., Zboril EK; Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States., De La Chapa JJ; Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States., Chai X; Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States., Da Conceicao VN; Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States., Valdez MC; Department of Chemistry and the Center for Innovative Drug Discovery, University of Texas at San Antonio, San Antonio, TX, United States., McHardy SF; Department of Chemistry and the Center for Innovative Drug Discovery, University of Texas at San Antonio, San Antonio, TX, United States., Gonzales CB; Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States., Singh BB; Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX, United States.

Publikováno v: Frontiers in physiology [Front Physiol] 2022 Sep 15; Vol. 13, pp. 969000. Date of Electronic Publication: 2022 Sep 15 (Print Publication: 2022).

Loss of Ca ²⁺ entry via Orai-TRPC1 induces ER stress, initiating immune activation in macrophages.

Autor: Nascimento Da Conceicao V; Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78229, USA., Sun Y; Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78229, USA., Zboril EK; Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78229, USA., De la Chapa JJ; Department of Comprehensive Dentistry, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78229, USA., Singh BB; Department of Periodontics, School of Dentistry, University of Texas Health San Antonio, San Antonio, TX 78229, USA singhbb@uthscsa.edu.

Publikováno v: Journal of cell science [J Cell Sci] 2019 Dec 18; Vol. 133 (5). Date of Electronic Publication: 2019 Dec 18.

The novel capsazepine analog, CIDD-99, significantly inhibits oral squamous cell carcinoma in vivo through a TRPV1-independent induction of ER stress, mitochondrial dysfunction, and apoptosis.

Autor: De La Chapa JJ; Department of Comprehensive Dentistry, School of Dentistry, UT Health San Antonio, San Antonio, Texas., Singha PK; Department of Pathology, School of Medicine, UT Health San Antonio, San Antonio, Texas., Self KK; Department of Comprehensive Dentistry, School of Dentistry, UT Health San Antonio, San Antonio, Texas., Sallaway ML; Department of Comprehensive Dentistry, School of Dentistry, UT Health San Antonio, San Antonio, Texas., McHardy SF; Center for Innovative Drug Discovery, Department of Chemistry, University of Texas at San Antonio, San Antonio, Texas.; Mays Cancer Center, UT Health San Antonio, San Antonio, Texas., Hart MJ; Mays Cancer Center, UT Health San Antonio, San Antonio, Texas.; Center for Innovative Drug Discovery, HTS Facility, Department of Biochemistry and Structural Biology, UT Health San Antonio, San Antonio, Texas., McGuff HS; Department of Pathology, School of Medicine, UT Health San Antonio, San Antonio, Texas., Valdez MC; Center for Innovative Drug Discovery, Department of Chemistry, University of Texas at San Antonio, San Antonio, Texas., Ruiz F 2nd; Center for Innovative Drug Discovery, Department of Chemistry, University of Texas at San Antonio, San Antonio, Texas., Polusani SR; Center for Innovative Drug Discovery, HTS Facility, Department of Biochemistry and Structural Biology, UT Health San Antonio, San Antonio, Texas., Gonzales CB; Department of Comprehensive Dentistry, School of Dentistry, UT Health San Antonio, San Antonio, Texas.; Mays Cancer Center, UT Health San Antonio, San Antonio, Texas.

Publikováno v: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology [J Oral Pathol Med] 2019 May; Vol. 48 (5), pp. 389-399. Date of Electronic Publication: 2019 Apr 04.