Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Chaoyang Dai"'
Autor:
Paul Kirschmeier, Daniel J. Hicklin, M. Arshad Siddiqui, Payal R. Sheth, Huadong Tang, Elizabeth Smith, Bohdan Yaremko, Abdul Ponery, Lianzhu Liang, Suining Lee, Seema Tevar, Lissette Nale, Kimberly Gray, Chaoyang Dai, Ming Liu, Andrea D. Basso
Supplementary Tables 1, 2, and 3 and Supplementary Figures 1 and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323e1342aa3b907de9717e370e74f9ef
https://doi.org/10.1158/1535-7163.22484694.v1
https://doi.org/10.1158/1535-7163.22484694.v1
Autor:
Paul Kirschmeier, Daniel J. Hicklin, M. Arshad Siddiqui, Payal R. Sheth, Huadong Tang, Elizabeth Smith, Bohdan Yaremko, Abdul Ponery, Lianzhu Liang, Suining Lee, Seema Tevar, Lissette Nale, Kimberly Gray, Chaoyang Dai, Ming Liu, Andrea D. Basso
Kinesin spindle protein (KSP) is a mitotic kinesin required for the formation of the bipolar mitotic spindle, and inhibition of this motor protein results in mitotic arrest and cell death. KSP inhibitors show preclinical antitumor activity and are cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6041f2cd41a43e8a9ab2086483f35521
https://doi.org/10.1158/1535-7163.c.6531537
https://doi.org/10.1158/1535-7163.c.6531537
Publikováno v:
2020 IEEE International Conference on High Voltage Engineering and Application (ICHVE).
Accurately acquiring radar echoes from wind turbines is the key to solving the passive interference of wind farms to radar stations. Because the existing superposition model of scattering points cannot achieve accurate simulation of wind turbine echo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9659d68d6a9cb3580cba9061d93254e2
https://doi.org/10.1109/ichve49031.2020.9279841
https://doi.org/10.1109/ichve49031.2020.9279841
Publikováno v:
2020 IEEE International Conference on High Voltage Engineering and Application (ICHVE).
In order to reduce the data processing of radar system and realize the real-time target recognition of wind turbines, it is necessary to find a fast solution to the scattering electric field of wind turbine blades. Aiming at the problem that the trad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::472cff200f9db1d00870f2c614e516f9
https://doi.org/10.1109/ichve49031.2020.9279800
https://doi.org/10.1109/ichve49031.2020.9279800
Publikováno v:
2020 IEEE International Conference on High Voltage Engineering and Application (ICHVE).
Accurately simulating the wind generator radar echo signal to obtain its unique Doppler characteristics is of great significance for solving the problem of passive interference of wind turbines to radar stations. In this paper, considering the differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ae33b6a648944837f2e51387210b557
https://doi.org/10.1109/ichve49031.2020.9279549
https://doi.org/10.1109/ichve49031.2020.9279549
Autor:
Guowei Zhou, Liping Yang, Neng-Yang Shih, M. Arshad Siddiqui, Vinay Girijavallabhan, Shiying Chen, Lei Chen, Dansu Li, Peter Orth, Zhuyan Guo, Bandarpalle B. Shankar, Kristin E. Rosner, Wensheng Yu, Ling Tong, Chaoyang Dai, Joseph A. Kozlowski, Aneta Kosinski, Xiaoda Niu, Seong Heon Kim, Daniel Lundell, Shelby Umland, Janeta Popovici-Muller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3037-3042
We have identified a series of hydantoin-derived TNF-a converting enzyme (TACE) inhibitors containing a pendant fused bi-heteroaryl group, which demonstrate sub-nanomolar potency (Ki), excellent activity in human whole blood assay, and improved DMPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9ae78bb60384e5c554a062fa84b16e
https://doi.org/10.1016/j.bmcl.2017.05.062
https://doi.org/10.1016/j.bmcl.2017.05.062
Autor:
Wenjie Zhang, Hanzhong Wang, Yahong Ding, Ze Chen, Jian Luo, Tao Zhang, Mei Zheng, Yinglei Yi, Chaoyang Dai, Fen Liu, Bing Sun, Xueliang Wang, Dan Zheng
Publikováno v:
Archives of Virology. 157:1451-1461
Our previous studies have proven the adjuvanticity of chitosan in mice when administered with inactivated and subunit influenza vaccine. In this study, we investigated the adjuvant effect of chitosan on the immunogenicity and protective efficacy of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83475d75fcf986a94f132d20f87a311a
https://doi.org/10.1007/s00705-012-1318-7
https://doi.org/10.1007/s00705-012-1318-7
Autor:
Peter Orth, Bandarpalle B. Shankar, Daniel Lundell, Corey O. Strickland, Vinay Girijavallabhan, Chaoyang Dai, Joseph A. Kozlowski, Janeta Popovici-Muller, Brian J. Lavey, Jing Sun, Shiying Chen, Dansu Li, John J. Piwinski, Razia Rizvi, M. Arshad Siddiqui, Kristin E. Rosner, Lianyun Zhao, Zhuyan Guo, Wong Michael K C, Neng-Yang Shih, Xiaoda Niu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3172-3176
TNF-α converting enzyme (TACE) inhibitors are promising agents to treat inflammatory disorders and cancer. We have investigated novel tartrate diamide TACE inhibitors where the tartrate core binds to zinc in a unique tridentate fashion. Incorporatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ffe3fdf02a5dba0580b311b55f7fe2
https://doi.org/10.1016/j.bmcl.2011.01.002
https://doi.org/10.1016/j.bmcl.2011.01.002
Autor:
Liping Yang, Shelby Umland, Peter Orth, Daniel Lundell, Luke Firmansjah, Feltz Robert, Chaoyang Dai, Joseph A. Kozlowski, Wensheng Yu, Janeta Popovici-Muller, Seong Heon Kim, Vincent S. Madison, John J. Piwinski, De-Yi Yang, M. Arshad Siddiqui, Ling Tong, Xiaoda Niu, Brian J. Lavey, Guowei Zhou, Banderpalle B. Shankar, Razia Rizvi, Kristin E. Rosner, Neng-Yang Shih, Aneta Kosinski, Hong Bian, Dansu Li, Vinay Girijavallabhan, Lei Chen, Himanshu Shah, Zhuyan Guo, Jing Sun, Wong Michael K C
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7283-7287
Our research on hydantoin based TNF-α converting enzyme (TACE) inhibitors has led to an acetylene containing series that demonstrates sub-nanomolar potency (K(i)) as well as excellent activity in human whole blood. These studies led to the discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f13e3eb17b7abab77da7bd68ad794d7
https://doi.org/10.1016/j.bmcl.2010.10.081
https://doi.org/10.1016/j.bmcl.2010.10.081
Autor:
Andrea D. Basso, Angie R. Angeles, Liping Yang, M. Arshad Siddiqui, Andrew Brunskill, Chaoyang Dai
Publikováno v:
Tetrahedron Letters. 51:6236-6239
A facile and highly convergent synthesis of biologically active spiro-fused thiadiazoline KSP inhibitors is reported. The highlights of the synthesis include the Michael reaction and cyclization of thiosemicarbazone to 1,3,4-thiadiazoline. This chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::087951d638ec7c072f70a3863d996f0b
https://doi.org/10.1016/j.tetlet.2010.09.066
https://doi.org/10.1016/j.tetlet.2010.09.066