Effects of Thymoquinone on Small-Molecule Metabolites in a Rat Model of Cerebral Ischemia Reperfusion Injury Assessed using MALDI-MSI

Autor: Fang Tian, Runzhe Liu, Chaoxin Fan, Yi Sun, Xi Huang, Zongxiu Nie, Xin Zhao, Xiaoping Pu

Publikováno v: Metabolites, Vol 10, Iss 1, p 27 (2020)

Thymoquinone is one of the main components present in Nigella sativa seeds and is known to have various biological functions in inflammation, oxidative stress, tumors, aging, and in lowering blood glucose levels. Few studies have focused on its neuro

Externí odkaz: https://doaj.org/article/a030295d096d494d90ae5f233128eee1

The allele frequency of EGFR T790M in ctDNA predicted clinical outcomes of Osimertinib in non-small cell lung cancer patients from a real-world study

Autor: Xiao Fu, Tingting Shi, Mengjie Liu, Xiaoqiang Zheng, Haoran Zheng, Chaoxin Fan, Rui Zhang, Xue Chen, Lili Jiang, Wenjuan Wang, Yujuan Yang, Xuan Liang, Zhiping Ruan, Tao Tian, Yu Yao

Background: The clinical and molecular factors that associated with the response to Osimertinib in the patients who have acquired resistance to the first or second-generation of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba2c57787d40d4e1aca4a8743b5a8dab
https://doi.org/10.21203/rs.3.rs-1658925/v1

Integration of Single-Cell RNA Sequencing and Bulk RNA Sequencing Data to Establish and Validate a Prognostic Model for Patients With Lung Adenocarcinoma

Autor: Aimin Jiang, Jingjing Wang, Na Liu, Xiaoqiang Zheng, Yimeng Li, Yuyan Ma, Haoran Zheng, Xue Chen, Chaoxin Fan, Rui Zhang, Xiao Fu, Yu Yao

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

Background: Lung adenocarcinoma (LUAD) remains a lethal disease worldwide, with numerous studies exploring its potential prognostic markers using traditional RNA sequencing (RNA-seq) data. However, it cannot detect the exact cellular and molecular ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbf2bf29508c7b1309f257a1aa4c2c1
https://pubmed.ncbi.nlm.nih.gov/35154287

Effects of Dl-3-n-butylphthalide on Cerebral Ischemia Infarction in Rat Model by Mass Spectrometry Imaging

Autor: Runzhe Liu, Yi Sun, Xin Zhao, Chaoxin Fan, Zongxiu Nie, Zhilin Zhang, Huihui Liu, Xiao-Ping Pu

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 11; Pages: 2451
International Journal of Molecular Sciences, Vol 18, Iss 11, p 2451 (2017)

Dl-3-n-butylphthalide (NBP) is a drug that is used in the treatment of ischaemic stroke. However, to the best of our knowledge, there are no systematic studies investigating the effects of dl-3-n-butylphtalide on the brain metabolism of small molecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf68bb4b2b7d9bced617a3f9ad42ca7
http://europepmc.org/articles/PMC5713418