Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Chaoqin Xie"'
Autor:
Lukas J. Motloch, MD, PhD, Kiyotake Ishikawa, MD, Chaoqin Xie, MD, Jun Hu, PhD, Jaume Aguero, MD, Kenneth M. Fish, PhD, Roger J. Hajjar, MD, Fadi G. Akar, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 2, Iss 3, Pp 258-269 (2017)
Summary: Although the pathophysiological significance of resistant hypertension in postâmyocardial infarction (MI) patients is established, the mechanisms by which increased afterload in that setting worsens outcome are unclear. With regard to sudde
Externí odkaz:
https://doaj.org/article/567e3ad87774479d87bf53f3def6720d
Autor:
Lukas J. Motloch, Marine Cacheux, Kiyotake Ishikawa, Chaoqin Xie, Jun Hu, Jaume Aguero, Kenneth M. Fish, Roger J. Hajjar, Fadi G. Akar
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 18 (2018)
Background SERCA2a gene transfer (GT) improves mechano‐electrical function in animal models of nonischemic heart failure Whether SERCA2a GT reverses pre‐established remodeling at an advanced stage of ischemic heart failure is unclear. We sought t
Externí odkaz:
https://doaj.org/article/35cb35932287459a889787e0ed9d9a8b
Autor:
Moritz Konkel, Ebru Gurel-Gurevin, Cees A. Schumacher, Nina C. Weber, Coert J. Zuurbier, Otto Eerbeek, Egbert G. Mik, Fadi G. Akar, G. Sjoerd Deijs, Chaoqin Xie, Markus W. Hollmann, Jun Hu, Antonius Baartscheer, Rianne Nederlof
Publikováno v:
Journal of Physiology and Biochemistry
Journal of Physiology and Biochemistry, 73(3), 323-333. Springer Netherlands
Journal of physiology and biochemistry, 73(3), 323-333. Springer Netherlands
Journal of Physiology and Biochemistry, 73(3), 323-333. Springer Netherlands
Journal of physiology and biochemistry, 73(3), 323-333. Springer Netherlands
Ischemia/reperfusion (I/R) of the heart becomes injurious when duration of the ischemic insult exceeds a certain threshold (approximately ≥20 min). Mitochondrial bound hexokinase II (mtHKII) protects against I/R injury, with the amount of mtHKII co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8413a132e51131dfadd6ef40a596a3e4
https://pure.eur.nl/en/publications/429c0ba6-a218-45cc-9d6e-d8e5e5f22168
https://pure.eur.nl/en/publications/429c0ba6-a218-45cc-9d6e-d8e5e5f22168
Autor:
Kiyotake Ishikawa, Chaoqin Xie, Kenneth Fish, Jaume Aguero, Lukas J. Motloch, Jun Hu, Marine Cacheux, Roger J. Hajjar, Fadi G. Akar
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background SERCA 2a gene transfer ( GT ) improves mechano‐electrical function in animal models of nonischemic heart failure Whether SERCA 2a GT reverses pre‐established remodeling at an advanced stage of ischemic heart failure is unclear. We soug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1c2878cf9140330dea087ee3c004c3
https://doi.org/10.1161/jaha.118.009598
https://doi.org/10.1161/jaha.118.009598
Autor:
Fadi G. Akar, Monica Palmeri, Xiaohong Wu, Lawrence H. Young, Joseph G. Akar, Jenna L. Ross, Kevin N. Su, Vlad G. Zaha, Grace Kim, Mohammed Ashraf, Kerry S. Russell, Chaoqin Xie
Publikováno v:
Cardiovascular Research. 108:197-208
Aims Liver kinase B1 (LKB1) is a protein kinase that activates the metabolic regulator AMP-activated protein kinase (AMPK) and other related kinases. Deletion of LKB1 in mice leads to cardiomyopathy and atrial fibrillation (AF). However, the specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d004ed15fb7f249bcfb560ac1c436447
https://doi.org/10.1093/cvr/cvv212
https://doi.org/10.1093/cvr/cvv212
Autor:
Jade Samulski, Ahyoung Lee, Jaume Aguero, Scott W.J. McPhee, Chaoqin Xie, Fadi G. Akar, Yuichi J. Shimada, Carlos G. Santos-Gallego, Lisa Tilemann, Thomas Weber, Daniel C. Sigg, Aravind Asokan, Kleopatra Rapti, Ioannis Karakikes, Richard Jude Samulski, Evangelia G. Kranias, Kenneth Fish, Kiyotake Ishikawa, Roger J. Hajjar, Judith K. Gwathmey
Publikováno v:
Molecular Therapy. 22(12):2038-2045
Cardiac gene therapy has emerged as a promising option to treat advanced heart failure (HF). Advances in molecular biology and gene targeting approaches are offering further novel options for genetic manipulation of the cardiovascular system. The aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954b4a170b624e6b3e659a447b6ab83c
Autor:
Thomas Weber, Evangelia G. Kranias, Kenneth Fish, Lifan Liang, Lauren Leonardson, Ahyoung Lee, Lukas J. Motloch, Erik Kohlbrenner, Philyoung Lee, Kiyotake Ishikawa, Chaoqin Xie, Maritza Mcintyre, Changwon Kho, Shin Watanabe, Fadi G. Akar, Roger J. Hajjar, Scott T. Wilson, R. Jude Samulski, Jae Gyun Oh
Publikováno v:
Journal of the American College of Cardiology. 70(14)
Increased protein phosphatase-1 in heart failure (HF) induces molecular changes deleterious to the cardiac cell. Inhibiting protein phosphatase-1 through the overexpression of a constitutively active inhibitor-1 (I-1c) has been shown to reverse cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ec57b263fe41236a854b25b2c5ef50
https://pubmed.ncbi.nlm.nih.gov/28958333
https://pubmed.ncbi.nlm.nih.gov/28958333
Autor:
Grant Senyei, Ronald A. Li, Jean-Sébastien Hulot, Irene C. Turnbull, Roger J. Hajjar, Kevin D. Costa, Gregory Serrao, Jia Jye Lee, Fadi G. Akar, Peter Backeris, Ioannis Karakikes, Ronald E. Gordon, Chaoqin Xie
Publikováno v:
The FASEB Journal. 28:644-654
Cardiac experimental biology and translational research would benefit from an in vitro surrogate for human heart muscle. This study investigated structural and functional properties and interventional responses of human engineered cardiac tissues (hE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd6a2d9f82efdff445a3e08badcb83b
https://doi.org/10.1096/fj.13-228007
https://doi.org/10.1096/fj.13-228007
Autor:
Miguel A. Aon, Nazareno Paolocci, Nora Biary, Justin Kauffman, Carlo G. Tocchetti, Fadi G. Akar, Chaoqin Xie
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 304:H916-H926
Chronic hyperglycemia in type-1 diabetes mellitus is associated with oxidative stress (OS) and sudden death. Mechanistic links remain unclear. We investigated changes in electrophysiological (EP) properties in a model of chronic hyperglycemia before
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a8d7e61ee4af6b557e725ee323ff65
https://doi.org/10.1152/ajpheart.00026.2012
https://doi.org/10.1152/ajpheart.00026.2012
Publikováno v:
Circulation Research. 119
In structurally normal hearts, inhibition of the mitochondrial translocator protein (TSPO) prevents ROS-mediated proarrhythmia. Whether and how TSPO modulates electrophysiological (EP) function of diabetic hearts, in which classically cardioprotectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88dd98b25bff8e81b8462da4701c30dd
https://doi.org/10.1161/res.119.suppl_1.441
https://doi.org/10.1161/res.119.suppl_1.441