Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Chaoling Qu"'
Autor:
Navratilova, Edita, Chaoling Qu, Guangchen Ji, Neugebauer, Volker, Guerrero, Miguel, Rosen, Hugh, Roberts, Edward, Porreca, Frank
Publikováno v:
Anesthesiology; Feb2024, Vol. 140 Issue 2, p272-283, 12p
Publikováno v:
Cell reports
SUMMARY Pyramidal neurons in the anterior cingulate cortex (ACC), a prefrontal region involved in processing the affective components of pain, display hyperexcitability in chronic neuropathic pain conditions, and their silencing abolishes hyperalgesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b604b0985d0b69e042f97f7d77f4cd
https://doi.org/10.1016/j.celrep.2021.109933
https://doi.org/10.1016/j.celrep.2021.109933
Autor:
Janice Oyarzo, Kirsty Bannister, Frank Porreca, Tamara King, Jennifer Y. Xie, Chaoling Qu, Edita Navratilova, Anthony H. Dickenson
Publikováno v:
Bannister, K, Qu, C, Navratilova, E, Oyarzo, J, Xie, J Y, King, T, Dickenson, A H & Porreca, F 2017, ' Multiple sites and actions of gabapentin-induced relief of ongoing experimental neuropathic pain ', Pain, vol. 158, no. 12, pp. 2386-2395 . https://doi.org/10.1097/j.pain.0000000000001040
Gabapentin is a first-line therapy for neuropathic pain but its mechanisms and sites of action remain uncertain. We investigated gabapentin-induced modulation of neuropathic pain following spinal nerve ligation (SNL) in rats. Intravenous or intrathec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e987ee115eae3e22464bf6a28b253ff5
https://doi.org/10.1097/j.pain.0000000000001040
https://doi.org/10.1097/j.pain.0000000000001040
Autor:
Frank Porreca, Xiaofang Yang, Song Cai, Lindsey A. Chew, Jennifer Y. Xie, Shreya S. Bellampalli, Liberty François-Moutal, Kerry B. Gilbraith, Wennan Li, Seul Ki Yeon, May Khanna, Rajesh Khanna, Shizhen Luo, Ki Duk Park, Mohab M. Ibrahim, Chaoling Qu, Aubin Moutal
Publikováno v:
Pain. 158:2301-2319
Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disease linked to mutations of the Nf1 gene. Patients with NF1 commonly experience severe pain. Studies on mice with Nf1 haploinsufficiency have been instructive in identifying sensitization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96d6a5ed26765385dc7bf4d9b0ad785
https://doi.org/10.1097/j.pain.0000000000001002
https://doi.org/10.1097/j.pain.0000000000001002
Publikováno v:
Pain
Careful attention to study design, bioactive material, and drug exposure was used in replication of a single study supporting efficacy of Meteorin in experimental neuropathic pain.
Data from preclinical research have been suggested to suffer fro
Data from preclinical research have been suggested to suffer fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6d77271d378b78521a3e9ce6bad5d5
https://pubmed.ncbi.nlm.nih.gov/31335652
https://pubmed.ncbi.nlm.nih.gov/31335652
Autor:
Volker Neugebauer, Edita Navratilova, Vadim Yakhnitsa, Frank Porreca, Caroline E. Phelps, Guangchen Ji, Chaoling Qu, Matthew Hein
Publikováno v:
Pain. 160(4)
Chronic pain is associated with neuroplastic changes in the amygdala that may promote hyper-responsiveness to mechanical and thermal stimuli (allodynia and hyperalgesia) and/or enhance emotional and affective consequences of pain. Stress promotes dyn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d119b02ba8945f6020b09e02e348c1f4
https://pubmed.ncbi.nlm.nih.gov/30681985
https://pubmed.ncbi.nlm.nih.gov/30681985
Autor:
Chaoling Qu, Jennifer Y. Xie, David J. Wasiak, Kelvin W. Gee, Timothy B C Johnstone, Frank Porreca, Derk J. Hogenkamp
Publikováno v:
Pain, vol 160, iss 1
Chronic neuropathic pain may be caused, in part, by loss of inhibition in spinal pain processing pathways due to attenuation of local GABAergic tone. Nociception and nocifensive behaviors are reduced after enhancement of tonically activated extrasyna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0880e0be16f4ebda5ad6174bfd207fef
https://escholarship.org/uc/item/71k240r2
https://escholarship.org/uc/item/71k240r2
Autor:
Frank Porreca, Chaoling Qu, Lindsay LeBaron, Yeon Sun Lee, Cyf Ramos-Colon, Victor J. Hruby, Jennifer Y. Xie, Sara M. Hall, Josephine Lai
Publikováno v:
ACS Chemical Neuroscience. 7:1746-1752
Dynorphin A (Dyn A) is a unique endogenous ligand that possesses well-known neuroinhibitory effects via opioid receptors with a preference for the kappa receptor but also neuroexcitatory effects, which cause hyperalgesia. We have shown that the neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919cd1c40e2825eec312b2b397bea5ad
https://doi.org/10.1021/acschemneuro.6b00258
https://doi.org/10.1021/acschemneuro.6b00258
Autor:
Frank Porreca, Jennifer Y. Xie, Raghuraman Shrinivasan, Kerry B. Gilbraith, Chaoling Qu, Edwin Telemi, May Khanna, Rajesh Khanna, Lindsey A. Chew, Seul Ki Yeon, Yue Wang, Seeneen Meroueh, Amol M. Patwardhan, Aubin Moutal, Todd W. Vanderah, Xiaofang Yang, Ki Duk Park
Publikováno v:
Pain. 157:1448-1463
Chronic pain affects the life of millions of people. Current treatments have deleterious side effects. We have advanced a strategy for targeting protein interactions which regulate the N-type voltage-gated calcium (CaV2.2) channel as an alternative t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f63d8d3539b05700d87b5175897fa46
https://doi.org/10.1097/j.pain.0000000000000555
https://doi.org/10.1097/j.pain.0000000000000555
Publikováno v:
Pain. 159(9)
Pontine noradrenergic neurones form part of a descending inhibitory system that influences spinal nociceptive processing. Weak or absent descending inhibition is a common feature of chronic pain patients. We examined the extent to which the descendin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::67a72ac545e4cd900043b6a67f51c21e
https://pubmed.ncbi.nlm.nih.gov/29863529
https://pubmed.ncbi.nlm.nih.gov/29863529