Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Chaojun Han"'
Autor:
Yafei Zhao, Panpan Wang, Shuangshuang Chen, Chaojun Han, Qiuting Yan, Longtai Zheng, Jia Jia, Zhaoxiang Ren, Xuechu Zhen
Publikováno v:
Journal of Functional Foods, Vol 33, Iss , Pp 76-84 (2017)
Dihydromyricetin (DHM), a natural flavonoid compound extracted from the fruit Ampelopsis grossedentata, exerts various pharmacological effects. We explored the neuroprotective effects of DHM following cerebral ischemia. Male ICR mice were intraperito
Externí odkaz:
https://doaj.org/article/c4b71feaab5048edb2858ad20d9c06c3
Autor:
Tao He, Chaojun Han, Chun Liu, Jiaojiao Chen, Huicui Yang, Longtai Zheng, John L. Waddington, Xuechu Zhen
Publikováno v:
Psychopharmacology. 239:951-964
Clinical studies have revealed that methamphetamine abuse increases risk for developing Parkinson's diseases. It is thus important to elucidate the mechanisms by which methamphetamine damages dopaminergic neurons.The present study was designed to elu
Autor:
Xinya, Xu, Yundong, Xie, Pengqi, Guo, Yongheng, Shi, Meng, Sun, Jing, Zhou, Chuan, Wang, Chaojun, Han, Jiping, Liu, Ting, Li
Publikováno v:
Food Chemistry. 404:134645
Highly selective recognition and purification of target proteins from complex biological matrices remains a challenging subject in natural and life sciences. Compared with natural recognition receptors, artificial imprinted polymers are an ideal alte
Autor:
Peng-ju Yan, Zhaoxiang Ren, Zhi-feng Shi, Liu-shuai Zhu, Ning-ning Li, Chaojun Han, Chun-lei Wan, John L. Waddington, Xuechu Zhen
Publikováno v:
Acta Pharmacol Sin
Chronic administration of methamphetamine (METH) leads to physical and psychological dependence. It is generally accepted that METH exerts rewarding effects via competitive inhibition of the dopamine transporter (DAT), but the molecular mechanism of
The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway
Autor:
Xiaohu Zhang, Jiyue Zheng, Lin Sun, Chaojun Han, Zhong-qiang Cao, Xuechu Zhen, Huicui Yang, Long Tai Zheng
Publikováno v:
Acta Pharmacol Sin
Microglia, the brain-resident macrophage, is known as the innate immune cell type in the central nervous system. Microglia is also the major cellular component of tumor mass of gliomas that plays a key role in glioma development. Mutations of isocitr
Autor:
Chun-lei Wan, John L. Waddington, Kailian Zhu, Chaojun Han, Mingmei Wang, Xuechu Zhen, Tao He
Publikováno v:
Neuropharmacology. 196
Mitochondria are essential for neuronal survival and function, and mitochondrial dysfunction plays a critical role in the pathological development of Parkinson's disease (PD). Mitochondrial quality control is known to contribute to the survival of do
Publikováno v:
Brain, behavior, and immunity. 88
Microglia-mediated neuroinflammation plays an important role in the progression of neurodegenerative diseases including Parkinson's disease (PD). Pleckstrin homology-like domain family A member 1 (PHLDA1) plays an important role in immunological regu
Publikováno v:
Behavioural Brain Research. 410:113344
Astrocytes play important roles in the development of depression. As a promising target for antidepressant development, sigma-1 receptor (Sig-1R) is reported to promote activation of astrocyte in chronic stress-induced depression in our previous stud
Publikováno v:
Molecular Pharmacology. 92:640-652
The autophagy-lysosome pathway (ALP) plays a critical role in the pathology of Parkinson's disease (PD). Clk1 (coq7) is a mitochondrial hydroxylase that is essential for coenzyme Q (ubiquinone) biosynthesis. We have reported previously that Clk1 regu
Autor:
Jia Jia, Long Tai Zheng, Xuechu Zhen, Panpan Wang, Chaojun Han, Shuangshuang Chen, Zhaoxiang Ren, Qiuting Yan, Yafei Zhao
Publikováno v:
Journal of Functional Foods, Vol 33, Iss, Pp 76-84 (2017)
Dihydromyricetin (DHM), a natural flavonoid compound extracted from the fruit Ampelopsis grossedentata, exerts various pharmacological effects. We explored the neuroprotective effects of DHM following cerebral ischemia. Male ICR mice were intraperito