Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Chaohong, Sun"'
Autor:
Qi Hao, Manoj K. Rathinaswamy, Kelly L. Klinge, Matthew Bratkowski, Amirhossein Mafi, Christina K. Baumgartner, Keith M. Hamel, Gesine K. Veits, Rinku Jain, Claudio Catalano, Mark Fitzgerald, Alexander W. Hird, Eunice Park, Harit U. Vora, James A. Henderson, Kenton Longenecker, Charles W. Hutchins, Wei Qiu, Giovanna Scapin, Qi Sun, Vincent S. Stoll, Chaohong Sun, Ping Li, Dan Eaton, David Stokoe, Stewart L. Fisher, Christopher G. Nasveschuk, Marcia Paddock, Michael E. Kort
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract PTPN2 (protein tyrosine phosphatase non-receptor type 2, or TC-PTP) and PTPN1 are attractive immuno-oncology targets, with the deletion of Ptpn1 and Ptpn2 improving response to immunotherapy in disease models. Targeted protein degradation ha
Externí odkaz:
https://doaj.org/article/1f2680b79836478cba894b08e1a585a6
Autor:
Eric R. Goedken, Maria A. Argiriadi, Justin D. Dietrich, Andrew M. Petros, Navasona Krishnan, Sanjay C. Panchal, Wei Qiu, Haihong Wu, Haizhong Zhu, Ashley M. Adams, Pierre M. Bodelle, Lucas Goguen, Paul L. Richardson, Peter F. Slivka, Myron Srikumaran, Anup K. Upadhyay, Bainan Wu, Russell A. Judge, Anil Vasudevan, Sujatha M. Gopalakrishnan, Philip B. Cox, Vincent S. Stoll, Chaohong Sun
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Anti-IL17A therapies have proven effective for numerous inflammatory diseases including psoriasis, axial spondylitis and psoriatic arthritis. Modulating and/or antagonizing protein–protein interactions of IL17A cytokine binding to its cell
Externí odkaz:
https://doaj.org/article/73a129f16e244becaaa09ce714e81a66
Autor:
John T. Randolph, Matthew J. O’Connor, Fei Han, Charles W. Hutchins, Y. Amy Siu, Min Cho, Yunan Zheng, Jonathan A. Hickson, Jana L. Markley, Vlasios Manaves, Mikkel Algire, Kenton A. Baker, Alex M. Chapman, Sujatha M. Gopalakrishnan, Sanjay C. Panchal, Kelly Foster-Duke, DeAnne F. Stolarik, Anita Kempf-Grote, Darby Dammeier, Stacey Fossey, Qi Sun, Chaohong Sun, Yu Shen, Michael J. Dart, Warren M. Kati, Albert Lai, Ari J. Firestone, Michael E. Kort
Publikováno v:
Journal of Medicinal Chemistry. 66:3852-3865
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::941bc4bfb75cae4284f6cb7de0cad715
https://doi.org/10.1021/acs.jmedchem.2c01415
https://doi.org/10.1021/acs.jmedchem.2c01415
Publikováno v:
eLife, Vol 7 (2018)
eIF2B is a dedicated guanine nucleotide exchange factor for eIF2, the GTPase that is essential to initiate mRNA translation. The integrated stress response (ISR) signaling pathway inhibits eIF2B activity, attenuates global protein synthesis and upreg
Externí odkaz:
https://doaj.org/article/83d84271b4b942fab5fece615d525f1f
Autor:
Justin P Ingram, Russell A. Judge, Chang Park, Xilu Wang, Li Zhou, Sha Jin, Peter Kovar, Chaohong Sun, Andrew J. Souers, Steven W. Elmore, Haichao Zhang, Brian D. Wakefield, Joel D. Leverson, Jun Chen, Zhi-Fu Tao, Darren C. Phillips, Andrew S. Judd
Publikováno v:
ACS Medicinal Chemistry Letters. 12:1011-1016
BCL-XL, an antiapoptotic member of the BCL-2 family of proteins, drives tumor survival and maintenance and thus represents a key target for cancer treatment. Herein we report the rational design of a novel series of selective BCL-XL inhibitors exempl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f14863a3a8ba9a79583bbc0aee69f1b
https://doi.org/10.1021/acsmedchemlett.1c00162
https://doi.org/10.1021/acsmedchemlett.1c00162
Autor:
Kamaldeep Dhami, Anirban Chakraborty, Tarikere L. Gururaja, Leo W.-K. Cheung, Chaohong Sun, Felix DeAnda, XiaoDong Huang
Publikováno v:
Science signaling. 15(736)
The Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib irreversibly binds BTK at Cys481, inhibiting its kinase activity and thus blocking transduction of B cell receptor (BCR) signaling. Although ibrutinib is durably effective in patients with B ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e1c9df287305535807f1cd52da6a5c
https://pubmed.ncbi.nlm.nih.gov/35639855
https://pubmed.ncbi.nlm.nih.gov/35639855
Autor:
Kathy Sarris, Philip J. Hajduk, Ihle David C, Diana L. Donnelly-Roberts, Arthur Gomtsyan, Christian Goess, David B. Duignan, Danying Song, Chaohong Sun, Andrea Mcclure, Adrian D. Hobson, Robert H. Stoffel, Anil Vasudevan, John A. Mankovich, Sanjay C. Panchal, A. Chris Krueger, Steven L. Swann, Kenneth M. Comess, Andrew M. Petros, Wilson Noel S, Jill M. Wetter, Paul G. Richardson, Kenton L. Longenecker, Paul M. Jung, Vincent S. Stoll, Amanda W. Dombrowski, Suzanne Mathieu, Justin D. Dietrich, Philip B. Cox
Publikováno v:
Journal of Medicinal Chemistry. 64:417-429
Tumor necrosis factor α (TNFα) is a soluble cytokine that is directly involved in systemic inflammation through the regulation of the intracellular NF-κB and MAPK signaling pathways. The development of biologic drugs that inhibit TNFα has led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dbe3ede703ddd1435f27709b6c8281
https://doi.org/10.1021/acs.jmedchem.0c01280
https://doi.org/10.1021/acs.jmedchem.0c01280
Autor:
Sven Malchow, Alla Korepanova, Sanjay C. Panchal, Ryan A. McClure, Kenton L. Longenecker, Wei Qiu, Hongyu Zhao, Min Cheng, Jun Guo, Kelly L. Klinge, Patricia Trusk, Steven D. Pratt, Tao Li, Matthew D. Kurnick, Lishu Duan, Alex R. Shoemaker, Sujatha M. Gopalakrishnan, Scott E. Warder, J. Brad Shotwell, Albert Lai, Chaohong Sun, Augustine T. Osuma, William N. Pappano
Publikováno v:
ACS chemical biology. 17(3)
Hematopoietic progenitor kinase 1 (HPK1) is an MAP4K family member within the Ste20-like serine/threonine branch of the kinome. HPK1 expression is limited to hematopoietic cells and has a predominant role as a negative regulator of T cell function. B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41ef3dd8d993a23762cf2d11769d5f5
https://pubmed.ncbi.nlm.nih.gov/35188729
https://pubmed.ncbi.nlm.nih.gov/35188729
Autor:
Denise Wilcox, Vasudha Sehgal, Daniel H. Albert, John K. Pratt, Keith F. McDaniel, Xin Lu, Chaohong Sun, Dachun Liu, Joshua P. Plotnik, Srinivasa R. Mantena, Emily J. Faivre, Lisa A. Hasvold, George S. Sheppard, Xiaoli Huang, Le Wang, Lance J Bigelow, Stacey Fossey, Steve D. Fidanze, Lloyd T. Lam, Chang H. Park, Sanjay C. Panchal, Warren M. Kati, John J. Nicolette, Richard J. Bellin, Gaurav Mehta, Xiaoyu Lin, Mai H. Bui, Lu Zhang, Paul Hessler, Maricel Torrent, Tamar Uziel, Saul H. Rosenberg, Yu Shen, Kenton L. Longenecker
Publikováno v:
Nature. 578:306-310
Proteins of the bromodomain and extra-terminal (BET) domain family are epigenetic readers that bind acetylated histones through their bromodomains to regulate gene transcription. Dual-bromodomain BET inhibitors (DbBi) that bind with similar affinitie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8040bf69aa34810391b9a59139a83026
https://doi.org/10.1038/s41586-020-1930-8
https://doi.org/10.1038/s41586-020-1930-8
Autor:
Anup K. Upadhyay, Andrew M. Petros, Chaohong Sun, Andrew T. Namanja, Steven R. Van Doren, Jia Xu, Qi Sun, Haihong Wu
Publikováno v:
Journal of Biomolecular NMR. 73:675-685
Protein-based NMR spectroscopy has proven to be a very robust method for finding fragment leads to protein targets. However, one limitation of protein-based NMR is that the data acquisition and analysis can be time consuming. In order to streamline t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce3b37c313294ed47064f866eb097f0
https://doi.org/10.1007/s10858-019-00279-9
https://doi.org/10.1007/s10858-019-00279-9