Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Chaogu Zheng"'
Publikováno v:
eLife, Vol 13 (2024)
Tubulin posttranslational modifications (PTMs) modulate the dynamic properties of microtubules and their interactions with other proteins. However, the effects of tubulin PTMs were often revealed indirectly through the deletion of modifying enzymes o
Externí odkaz:
https://doaj.org/article/45158dd7b1fc40029c6a7cadd3b4d45c
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113865- (2024)
Summary: Microbial metabolites that can modulate neurodegeneration are promising therapeutic targets. Here, we found that the short-chain fatty acid propionate protects against α-synuclein-induced neuronal death and locomotion defects in a Caenorhab
Externí odkaz:
https://doaj.org/article/ab3a0072d64b46648f80598c59094bd1
Publikováno v:
Cell Genomics, Vol 4, Iss 1, Pp 100467- (2024)
Summary: Gene duplication produces the material that fuels evolutionary innovation. The “out-of-testis” hypothesis suggests that sperm competition creates selective pressure encouraging the emergence of new genes in male germline, but the somatic
Externí odkaz:
https://doaj.org/article/7c373b569d5f4ce7b6aceb0af7402aa1
Autor:
Chenyin Wang, Chaogu Zheng
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Emerging evidence from both clinical studies and animal models indicates the importance of the interaction between the gut microbiome and the brain in the pathogenesis of neurodegenerative diseases (NDs). Although how microbes modulate neurodegenerat
Externí odkaz:
https://doaj.org/article/0847b8749e064a658f7e8b3498132ec3
Autor:
Yu-Ming Lu, Chaogu Zheng
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Microtubules, made from the polymerization of the highly conserved α/β-tubulin heterodimers, serve as important components of the cytoskeleton in all eukaryotic cells. The existence of multiple tubulin isotypes in metazoan genomes and a dazzling va
Externí odkaz:
https://doaj.org/article/64c8b66f894b464bafd3fae37a9c8e18
Publikováno v:
PLoS Genetics, Vol 18, Iss 2, p e1010092 (2022)
Hox genes encode evolutionarily conserved transcription factors that specify regional identities along the anterior-posterior (A-P) axis. Although some Hox genes are known to regulate the differentiation of certain neurons, to what extent Hox genes a
Externí odkaz:
https://doaj.org/article/9eeecc791b8d4919982a4ada31c40f90
Autor:
Lingyan Shi, Chaogu Zheng, Yihui Shen, Zhixing Chen, Edilson S. Silveira, Luyuan Zhang, Mian Wei, Chang Liu, Carmen de Sena-Tomas, Kimara Targoff, Wei Min
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Non-destructive methods to image metabolism in situ in living tissues are limited. Here the authors combine deuterium oxide probing and stimulated Raman scattering microscopy to image lipid metabolic dynamics and protein synthesis in cells and in viv
Externí odkaz:
https://doaj.org/article/cdb87769bb72441c87752a122bb3677f
Publikováno v:
Cell Reports, Vol 13, Iss 7, Pp 1343-1352 (2015)
Cell differentiation usually occurs with high fidelity, but the expression of many transcription factors is variable. Using the touch receptor neurons (TRNs) in C. elegans, we found that the Hox proteins CEH-13/lab and EGL-5/Abd-B overcome this varia
Externí odkaz:
https://doaj.org/article/c80218ccba2040bc9bfb0278ab45ddc7
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1004017 (2013)
Although epigenetic control of stem cell fate choice is well established, little is known about epigenetic regulation of terminal neuronal differentiation. We found that some differences among the subtypes of Caenorhabditis elegans VC neurons, partic
Externí odkaz:
https://doaj.org/article/ffe360ead7e340c6859867ce06456ce2
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21146 (2011)
Carcinoembryonic antigen (CEA, CEACAM5, and CD66e) has been found to be associated with various types of cancers, particularly colorectal carcinoma, and developed to be a molecular target for cancer diagnosis and therapy. In present study, we generat
Externí odkaz:
https://doaj.org/article/f470a044dc7b4305b9f30b2c55428f36