Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Chaofeng Long"'
Autor:
Yuqin Yao, Zhuowei Liu, Manyu Zhao, Zhengxia Chen, Peng Li, Yang Zhang, Yuxi Wang, Chengjian Zhao, Chaofeng Long, Xiaoxin Chen, Jinliang Yang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1453-1475 (2020)
Angiokinases, such as vascular endothelial-, fibroblast- and platelet-derived growth factor receptors (VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis. Anti-angiogenesis therapy using multi-angiokinase inhibitor has achieved great
Externí odkaz:
https://doaj.org/article/38f72e4cdef544ae9c588050f698cbf3
Autor:
Wei Yan, Jianhong Yang, Huan Tang, Linlin Xue, Kai Chen, Lun Wang, Min Zhao, Minghai Tang, Aihua Peng, Chaofeng Long, Xiaoxin Chen, Haoyu Ye, Lijuan Chen
Publikováno v:
Journal of Advanced Research, Vol 20, Iss , Pp 117-127 (2019)
In this study, systematic separation and subsequent pharmacological activity studies were carried out to identify cytotoxic natural products from the dried stems of Millettia pachyloba Drake. Five previously undescribed isoflavones, pachyvones A–E;
Externí odkaz:
https://doaj.org/article/1cf7c135302145f5a076c82cfd52e602
Autor:
Xiaoxin Chen, Xiaodong Huang, Qinhai Ma, Petr Kuzmič, Biao Zhou, Jinxin Xu, Bin Liu, Haiming Jiang, Wenjie Zhang, Chunguang Yang, Shiguan Wu, Jianzhou Huang, Haijun Li, Chaofeng Long, Xin Zhao, Hongrui Xu, Yanan Sheng, Yaoting Guo, Chuanying Niu, Lu Xue, Yong Xu, Jinsong Liu, Tianyu Zhang, James Spencer, Wenbin Deng, Shu-Hui Chen, Xiaoli Xiong, Zifeng Yang, Nanshan Zhong
SARS-CoV-2 has demonstrated extraordinary ability to evade antibody immunity by antigenic drift. Small molecule drugs may provide effective therapy while being part of a solution to circumvent SARS-CoV-2 immune escape. In this study we report an α-k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb636ef6720c3a87a37c9ca83831c699
https://doi.org/10.21203/rs.3.rs-2634509/v1
https://doi.org/10.21203/rs.3.rs-2634509/v1
Autor:
Xiaoxin Chen, Peng Li, Jianzhou Huang, Yaxun Yang, Haoyu Zhang, Zheng Wang, Zhenzhen Zhu, Jingjing Wang, Jianchen Zhang, Kevin Chen, Haiying He, Chaofeng Long, Shuhui Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 90:129324
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b523fd52dcbf10f04dec04f26c24207a
https://doi.org/10.1016/j.bmcl.2023.129324
https://doi.org/10.1016/j.bmcl.2023.129324
Autor:
Zhuowei Liu, Yuxi Wang, Chengjian Zhao, Yang Zhang, Manyu Zhao, Jinliang Yang, Yuqin Yao, Peng Li, Chen Zhengxia, Xiaoxin Chen, Chaofeng Long
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1453-1475 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1453-1475 (2020)
Angiokinases, such as vascular endothelial-, fibroblast- and platelet-derived growth factor receptors (VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis. Anti-angiogenesis therapy using multi-angiokinase inhibitor has achieved great
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6380c470a4be26e380966eab21f579
http://europepmc.org/articles/PMC7488503
http://europepmc.org/articles/PMC7488503
Autor:
Zhuowei Liu, Xing Liu, Jiliang Zhang, Yuan Zhiliang, Chen Shuhui, Wang Jing, Zhang Xiao, Fengxun Guo, Jiang Zhigan, Jianhua Wang, Haiying He, Jian Li, Lijuan Hou, Chaofeng Long, Gong Zhen, Haijun Li, Chen Xiaoxin, Liang Shen, Deming Xu
Publikováno v:
ACS Med Chem Lett
[Image: see text] A novel peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist 5c was developed with an EC(50) of 8 nM for PPARα, 5 nM for PPARδ, and >300-fold selectivity against PPARγ (EC(50) = 2939 nM), respectively. Further ADM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25ae916652766966394bb6b056e17db
https://doi.org/10.1021/acsmedchemlett.9b00189
https://doi.org/10.1021/acsmedchemlett.9b00189
Autor:
Chaofeng Long, Jianhong Yang, Lun Wang, Min Zhao, Wei Yan, Xiaoxin Chen, Kai Chen, Lijuan Chen, Linlin Xue, Haoyu Ye, Minghai Tang, Huan Tang, Aihua Peng
Publikováno v:
Journal of Advanced Research
Journal of Advanced Research, Vol 20, Iss, Pp 117-127 (2019)
Journal of Advanced Research, Vol 20, Iss, Pp 117-127 (2019)
Graphical abstract
Highlights • Six new natural compounds were isolated from Millettia pachyloba Drake. • The cytotoxic activities of these new compounds were evaluated. • Ten (3–5, 9, 12, 17–19, 24, and 25) of 28 isolated compounds sh
Highlights • Six new natural compounds were isolated from Millettia pachyloba Drake. • The cytotoxic activities of these new compounds were evaluated. • Ten (3–5, 9, 12, 17–19, 24, and 25) of 28 isolated compounds sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c313c48644708afc521520d4c82d88
http://europepmc.org/articles/PMC6626068
http://europepmc.org/articles/PMC6626068
Autor:
Chaofeng Long, Kai Chen, Lun Wang, Minghai Tang, Xiaoxin Chen, Linlin Xue, Li Zheng, Lijuan Chen, Haoyu Ye, Huan Tang, Aihua Peng
Publikováno v:
Phytochemistry Letters. 25:60-64
Two new lignan derivatives and nine known compounds were isolated from the EtOAc and n-BuOH extracts of Millettia dorwardi Coll. Et. Hemsl. The structures of the compounds were determined by 1D and 2D NMR, CD and HRMS. Then, cytotoxic effects of thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e53de4a00915f08bde6a94c92365355
https://doi.org/10.1016/j.phytol.2018.03.004
https://doi.org/10.1016/j.phytol.2018.03.004
Autor:
Yikai Wang, Zhengxia Chen, Meibi Dai, Peipei Sun, Chunqiu Wang, Yang Gao, Haixia Zhao, Wenqin Zeng, Liang Shen, Weifeng Mao, Tian Wang, Guoping Hu, Jian Li, Shuhui Chen, Chaofeng Long, Xiaoxin Chen, Junhua Liu, Yang Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2420-2423
Introduction of a Michael acceptor on a flexible scaffold derived from pan-FGFR inhibitors has successfully yielded a novel series of highly potent FGFR4 inhibitors with selectivity over FGFR1. Due to reduced lipophilicity and aromatic ring count, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f83b85e91eaa3538b139bf8e25e58e7
https://doi.org/10.1016/j.bmcl.2017.04.014
https://doi.org/10.1016/j.bmcl.2017.04.014
Autor:
Chaofeng Long, Aihua Peng, Zhuowei Liu, Yuzhi Pu, Lijuan Chen, Yan Ran, Liang Ma, Linhong He, Minghai Tang, Heying Pei, Jinying Chen, Lei Lei, Suhong Fu
Publikováno v:
European Journal of Medicinal Chemistry. 87:595-610
Obesity accompanied with metabolic disorder is often complicated with a strong link of dyslipidemia and insulin resistance, whose indicator is the excess accumulation of triglycerides (TG) in cells. Consideration the idea of lipid-lowering and improv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d928ec0bd6762e87fedf65a1162794a
https://doi.org/10.1016/j.ejmech.2014.09.094
https://doi.org/10.1016/j.ejmech.2014.09.094