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Akademický článek

Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma

Autor: Senzhen Wang, Xiaojuan Xu, Delu Che, Ronghui Fan, Mengke Gao, Yue Cao, Chaochao Ge, Yongli Feng, Jinghua Li, Songqiang Xie, Chaojie Wang, Fujun Dai, Lei Gao, Yuxia Wang

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 20, p 10987 (2021)

Increasing the level of reactive oxygen species (ROS) in cancer cells has been suggested as a viable approach to cancer therapy. Our previous study has demonstrated that mitochondria-targeted flavone-naphthalimide-polyamine conjugate 6c elevates the

Externí odkaz: https://doaj.org/article/1b8b7b788e7a459f9b9fa9f327cd26aa

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Suppression of oxidative phosphorylation and IDH2 sensitizes colorectal cancer to a naphthalimide derivative and mitoxantrone

Autor: Fujun Dai, Chaojie Wang, Yuxia Wang, Yuan Zhao, Songqiang Xie, Zhiyang Zhang, Lei Gao, Chaochao Ge, Kemeng Zhang, Yanming Wang, Yongli Feng, Xiaojuan Xu, Senzhen Wang

Publikováno v: Cancer Letters. 519:30-45

Colorectal cancer (CRC) is one of the most prevalent cancers worldwide. Oxidative phosphorylation (OXPHOS) has attracted a considerable attention in CRC. It is of great interest to explore novel therapies that inhibit OXPHOS for CRC treatment. Compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc9f97dccbe6635c7bc430708bd7d31
https://doi.org/10.1016/j.canlet.2021.06.015

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Akademický článek

Design, Synthesis and Evaluation of Naphthalimide Derivatives as Potential Anticancer Agents for Hepatocellular Carcinoma.

Autor: Chaochao Ge^1,2 gechao1234365@163.com, Liping Chang² changlip@126.com, Ying Zhao¹ 15890173281@163.com, Congcong Chang² kuffychang@163.com, Xiaojuan Xu¹ xuxiaojuahn@163.com, Haoying He¹ hhy0926@foxmail.com, Yuxia Wang³ wangyuxia@henu.edu.cn, Fujun Dai² fjdwl@hotmail.com, Songqiang Xie⁴ xiesq@henu.edu.cn, Chaojie Wang² wcjsxq@henu.edu.cn

Publikováno v: Molecules. Feb2017, Vol. 22 Issue 2, p342. 17p. 4 Diagrams, 1 Chart, 3 Graphs.

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The Role of p53-Mediated Signaling in the Therapeutic Response of Colorectal Cancer to 9F, a Spermine-Modified Naphthalene Diimide Derivative

Autor: Xiaojuan Xu, Yuxia Wang, Songqiang Xie, Xinna Li, Yongli Feng, Chaochao Ge, Lei Gao, Senzhen Wang, Fujun Dai, Chaojie Wang

Publikováno v: Cancers, Vol 12, Iss 3, p 528 (2020)
Cancers; Volume 12; Issue 3; Pages: 528
Cancers

Colorectal cancer (CRC) is one of the most prevalent cancers due to its frequency and high rate of mortality. Polyamine-vectorized anticancer drugs possess multiple biological properties. Of these drugs, 9F has been shown to inhibit tumor growth and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e0f663c04849c32a1d50de0e5d0af8
https://www.mdpi.com/2072-6694/12/3/528

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Identification of molecular anti-metastasis mechanisms of lycorine in colorectal cancer by RNA-seq analysis

Autor: Chaojie Wang, Chaochao Ge, Songqiang Xie, Kemeng Zhang, Fujun Dai, Xiaojuan Xu, Lei Gao, Xinna Li, Yongli Feng, Senzhen Wang

Publikováno v: Phytomedicine : international journal of phytotherapy and phytopharmacology. 85

Background Colorectal cancer (CRC) is one of the most common malignancies worldwide. Metastasis is the major cause of death in patients with CRC. Lycorine, the phenanthridine alkaloid most commonly found in spp of the Amaryllidaceae family, has shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11bddfbc02837c408e183d74910b302
https://pubmed.ncbi.nlm.nih.gov/33761445

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Discovery of the Polyamine Conjugate with Benzo[cd]indol-2(1H)-one as a Lysosome-Targeted Antimetastatic Agent

Autor: Liu Xiaodan, Shuai Chen, Yuxia Wang, Runguo Tian, Songqiang Xie, Ying Chen, Wen Luo, Jinghua Li, Chaojie Wang, Fujun Dai, Chaochao Ge, Senzhen Wang, Ya-Cheng Yang

Publikováno v: Journal of Medicinal Chemistry. 61:6814-6829

Polyamine derivatives have a promising prospect in dealing with disseminated tumor cells, a major obstacle in cancer therapy. To develop a bifunctional polyamine derivative that can serve as a fluorescent probe and an antimetastatic agent, three kind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0193ff6b00ec352f2508c5d85faadb8b
https://doi.org/10.1021/acs.jmedchem.8b00694

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Synthesis and biological evaluation of novel alkylated polyamine analogues as potential anticancer agents

Autor: Zhiyong Tian, Meng Li, Fujun Dai, Yuxia Wang, Senzhen Wang, Songqiang Xie, Chaojie Wang, Chaochao Ge, Liping Chang, Luyao Zhao

Publikováno v: European Journal of Medicinal Chemistry. 143:1732-1743

A new class of polyamine analogues modified by alkylation at the terminal of the polyamine chain has been synthesized and their structures were determined by 1H NMR, 13C NMR, ESI-MS and elemental analysis. As the representative compound, 3f displayed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0497a605db20d172eb650ecff0e869
https://doi.org/10.1016/j.ejmech.2017.10.069

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Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma

Autor: Delu Che, Songqiang Xie, Ronghui Fan, Senzhen Wang, Yuxia Wang, Lei Gao, Mengke Gao, Yongli Feng, Fujun Dai, Chaojie Wang, Xiaojuan Xu, Chaochao Ge, Yue Cao, Jinghua Li

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 20
International Journal of Molecular Sciences, Vol 22, Iss 10987, p 10987 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55735be15b5c7beb7fd59436d09b55e
https://doi.org/10.3390/ijms222010987

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