Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Chao-Wu Yu"'
Autor:
Kang-Li Wang, Tsung-Yu Yeh, Pei-Chen Hsu, Tzu-Hsuan Wong, Jia-Rong Liu, Ji-Wang Chern, Miao-Hsia Lin, Chao-Wu Yu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractA series of novel benzimidazole derivatives were designed and synthesised based on the structures of reported oral available ALK inhibitor and HDAC inhibitor, pracinostat. In enzymatic assays, compound 3b, containing a 2-acyliminobenzimidazol
Externí odkaz:
https://doaj.org/article/17426bfae6b842ee8c54f5e27cc5db57
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204588 (2018)
The histone deacetylase inhibitor (HDACi) has been investigated for treating cancers and many other diseases as well as enhancing the reprogramming efficiency in cloned embryos for decades. In the present study, we investigated the effects of two nov
Externí odkaz:
https://doaj.org/article/ff1a54ab4cff4169a51430a5d7e06c83
Autor:
Yi-Hsun Ho, Hsing-Yi Lai, Hui-Ting Yang, Ji-Wang Chern, Chao-Wu Yu, Pei-Yun Hung, Yi-Sheng Cheng
Publikováno v:
Journal of Medicinal Chemistry. 62:857-874
We designed and synthesized quinazolin-2,4-dione-based hydroxamic acids to serve as selective competitive inhibitors of histone deacetylase-6 (HDAC6). The most potent and selective compound, 3d (IC50, 4 nM, HDAC6; IC50 > 10 μM, HDAC1), substantially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc87c43762f710f2c019bfca10cbf1e
https://doi.org/10.1021/acs.jmedchem.8b01590
https://doi.org/10.1021/acs.jmedchem.8b01590
Autor:
Sheang-Tze Fung, Yi-Hsun Ho, Pi-Hui Liang, Kuang-Jui Wang, Ji-Wang Chern, Jia-Rong Liu, Chao-Wu Yu, Pei-Yun Hung, Yi-Sheng Cheng
Publikováno v:
Organic & Biomolecular Chemistry. 16:7820-7832
HDAC6 receives great attention because of its therapeutic potential for the treatment of various diseases. Selective fluorescence imaging for HDAC6 is important for its pathological and biological studies. However, specific detection of HDAC6 by usin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94709fc91b0939244044b6eb0103e2a0
https://doi.org/10.1039/c8ob00966j
https://doi.org/10.1039/c8ob00966j
Publikováno v:
Biochemical pharmacology. 163
Glioblastoma is the most fatal type of primary brain cancer, and current treatments for glioblastoma are insufficient. HDAC6 is overexpressed in glioblastoma, and siRNA-mediated knockdown of HDAC6 inhibits glioma cell proliferation. Herein, we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322a61cf8a1a6b8f5228d661e590f1e9
https://pubmed.ncbi.nlm.nih.gov/30885763
https://pubmed.ncbi.nlm.nih.gov/30885763
Autor:
Ji-Wang Chern, Chao-Wu Yu, Cheng Peng, Ze-Hua Cheng, Yu-Hsuan Li, Yi-Sheng Cheng, Chen Tsung Huang, Ling-Wei Hsin, Jui-Ling Hsu, Hsueh Fen Juan, Jia-Rong Liu
Publikováno v:
Bioorganic Chemistry. 110:104813
MutT Homolog 1 (MTH1) has been proven to hydrolyze oxidized nucleotide triphosphates during DNA repair. It can prevent the incorporation of wrong nucleotides during DNA replication and mitigate cell apoptosis. In a cancer cell, abundant reactive oxyg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7508533409aa29a57206b5185319d7df
https://doi.org/10.1016/j.bioorg.2021.104813
https://doi.org/10.1016/j.bioorg.2021.104813
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204588 (2018)
PLoS ONE
PLoS ONE
The histone deacetylase inhibitor (HDACi) has been investigated for treating cancers and many other diseases as well as enhancing the reprogramming efficiency in cloned embryos for decades. In the present study, we investigated the effects of two nov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6b94fe2b67d77c21d4d3465ca5c1bfe
http://europepmc.org/articles/PMC6160101?pdf=render
http://europepmc.org/articles/PMC6160101?pdf=render
Autor:
Qing-qing Ye, Fan-Lu Kung, Ravindra Ramesh Deore, Chien Shu Chen, Ting-Rong Chern, Jung-Hsin Lin, Chen-Wei Huang, Ji-Wang Chern, Chao-Wu Yu, Rahul Subhash Talekar, Pei-Teh Chang, Grace Shiahuy Chen, Shin-Yu Lai, Min-Yan Yang
Publikováno v:
Neuropharmacology. 92:146-157
Alzheimer's disease is a neurodegenerative disorder characterized by deposition of β-amyloid (Aβ) fibrils accompanied with progressive neurite loss. None of the clinically approved anti-Alzheimer's agents target both pathological processes. We hypo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a6d786586a55e0e4bd4a05040593a7
https://doi.org/10.1016/j.neuropharm.2015.01.004
https://doi.org/10.1016/j.neuropharm.2015.01.004
Publikováno v:
Organic Letters. 14:3688-3691
An efficient microwave-assisted, palladium-catalyzed hydroxylation of aryl chlorides in the presence of a weak base carbonate was developed, which rapidly converts aryl and heteroaryl chlorides to phenols, and can be used when the aryl chloride is fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f980ece89292ed3cd8e2ca9ba42b9265
https://doi.org/10.1021/ol301523q
https://doi.org/10.1021/ol301523q
Publikováno v:
Journal of medicinal chemistry. 56(17)
Novel quinazolin-4-one derivatives containing a hydroxamic acid moiety were designed and synthesized. All compounds were subjected to histone deacetylase (HDAC) enzymatic assays to identify selective HDAC6 inhibitors with nanomolar IC50 values. (E)-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3674753af9536b622de6caf4f3a2a9ab
https://pubmed.ncbi.nlm.nih.gov/23905680
https://pubmed.ncbi.nlm.nih.gov/23905680