Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Chao-Guang Chen"'
Autor:
Anton Zalewski, Arna Andrews, Isabelle Glauser, Marcel Mischnik, Matthew P. Hardy, Anne M Verhagen, Kerstin Emmrich, Sabine Pestel, Con Panousis, Philipp Claar, Victor Turnbull, Chao-Guang Chen, Michael J. Wilson, Gregory T. Bass, Elmar Raquet, Steve K. Dower, Jenny Chia, Thomas Weimer, Vesna Tomasetig
Publikováno v:
Journal of Thrombosis and Haemostasis. 19:2710-2725
BACKGROUND We have recently reported on a recombinant von Willebrand factor (VWF) D'D3 albumin fusion protein (rD'D3-FP) developed to extend the half-life of coagulation factor VIII (FVIII) for the treatment of hemophilia A. Based on predictive model
Autor:
Catherine M. Owczarek, Peter Schmidt, Andrea Tester, Rebecca E. Butcher, Georgina Sansome, Chao-Guang Chen, Matthew P. Hardy, Rebecca Anne Bradford, Genevieve Martin-Roussety, Louis Fabri
Publikováno v:
Protein Expression and Purification. 159:75-82
The ability to engineer monoclonal antibodies (mAbs) with high specificity made mAbs the fastest growing segment in the drug market. mAbs represent 8 of the top 20 selling drugs with combined sales of more than 57 billion US$ per year. The ability to
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1701
We have recently described a one-step zero-background IgG reformatting method that enables the rapid reformatting of phage-displayed antibody fragments into a single-mammalian cell expression vector for full IgG expression (Chen et al. Nucleic Acids
Publikováno v:
Methods in Molecular Biology ISBN: 9781493974467
We have recently described a one-step zero-background IgG reformatting method that enables the rapid reformatting of phage-displayed antibody fragments into a single-mammalian cell expression vector for full IgG expression (Chen et al. Nucleic Acids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6a1a70a6dc6c105b6ffddbe34ef4f68
https://doi.org/10.1007/978-1-4939-7447-4_25
https://doi.org/10.1007/978-1-4939-7447-4_25
Autor:
Rolf Spirig, Adrian Zuercher, Bonnie J. B. Lewis, Jenny Chia, Jason Simmonds, Ian K. Campbell, Tony Rowe, Andreas Hofmann, Donald R. Branch, David Leong, Martin O. Spycher, Chao-Guang Chen, Louis Fabri, Monika Jordi, Con Panousis, Shirley Taylor, Ineke L. Muir, Jennifer Brasseit, Fabian Käsermann, Sandra Koernig, Rebecca E. Butcher, Peter Schmidt, Adriana Baz Morelli, Susann Cattepoel, Pierre Scotney
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(8)
Activation of Fc receptors and complement by immune complexes is a common important pathogenic trigger in many autoimmune diseases and so blockade of these innate immune pathways may be an attractive target for treatment of immune complex-mediated pa
Autor:
Matthew P. Hardy, Catherine M. Owczarek, Michael Abdo, Genevieve Martin-Roussety, Rebecca E. Butcher, Melanie Louise Ramunno, Pierre Scotney, Louis Fabri, Peter Schmidt, Chao-Guang Chen, Min-Yin Yap
Publikováno v:
Journal of chromatography. A. 1455
Monoclonal antibodies (mAbs) have become the fastest growing segment in the drug market with annual sales of more than 40 billion US$ in 2013. The selection of lead candidate molecules involves the generation of large repertoires of antibodies from w
Autor:
Ian G. Barr, Neil M O'Brien-Simpson, Paul D. Veith, Chao Guang Chen, Katrina A Walsh, Nada Slakeski, Eric C. Reynolds, Leanne T. Frazer
Publikováno v:
Vaccine. 24:6542-6554
Porphyromonas gingivalis is a pathogen associated with chronic periodontitis, an inflammatory disease of the supporting tissues of the teeth. A major virulence factor for P. gingivalis is the RgpA-Kgp proteinase-adhesin complex. We have prepared the
Autor:
Timothy R. Henion, Martin J. Pearse, Uri Galili, Anthony J F D'Apice, Evelyn Salvaris, Chao-Guang Chen, Helen Barlow, Trixie A. Shinkel
Publikováno v:
Transplantation. 64:197-204
BACKGROUND Inactivation of the alpha1,3-galactosyltransferase (GalT) gene by homologous recombination (knockout [KO] mice) and competition for the enzyme's N-acetyllactosamine substrate by transgenically expressed alpha1,2-fucosyltransferase (H-trans
Autor:
M. J. Tange, Marina Katerelos, Trixie A. Shinkel, Victoria Aitken, Chao-Guang Chen, Nella Fisicaro, Bryce J. W. van Denderen, Martin J. Pearse, Allan J. Robins, Anthony J. F. D'apice, Robert J. Crawford
Publikováno v:
Xenotransplantation. 3:69-75
There is now considerable evidence implicating anti-Gal xenoantibodies as a key instigator in the hyperacute rejection of discordant xenografts. As a consequence it is generally held that elimination or reduction of the Gal/anti-Gal component is crit
Publikováno v:
Molecular Immunology. 33:57-61
The activity of the transcription factor NF-kappaB is tightly regulated by the inhibitory molecule IkappaBalpha. Upon stimulation, IkappaBalpha is rapidly degraded and NF-kappaB translocates to the nucleus to induce gene expression. The IkappaBalpha