In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancer

Autor: Chao-Di Chang, Min-Wu Chao, Hsueh-Yun Lee, Yi-Ting Liu, Huang-Ju Tu, Ssu-Ting Lien, Tony Eight Lin, Tzu-Ying Sung, Shih-Chung Yen, Sing-Han Huang, Kai-Cheng Hsu, Shiow-Lin Pan

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)

Inhibiting a specific target in cancer cells and reducing unwanted side effects has become a promising strategy in pancreatic cancer treatment. MAP4K4 is associated with pancreatic cancer development and correlates with poor clinical outcomes. By pho

Externí odkaz: https://doaj.org/article/eeb87040e05f48b3ad27fb6a79897905

Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

Autor: Min-Wu Chao, Li-Hsun Chang, Huang-Ju Tu, Chao-Di Chang, Mei-Jung Lai, Yi-Ying Chen, Jing-Ping Liou, Che-Ming Teng, Shiow-Lin Pan

Publikováno v: Clinical Epigenetics, Vol 11, Iss 1, Pp 1-14 (2019)

Abstract Background Oncogenic K-Ras signaling highly relies on the canonical Ras/MEK/ERK pathway to contribute to pancreatic cancer progression. However, numerous efforts of MEK inhibitors have failed to provide an optimal antitumor effect for pancre

Externí odkaz: https://doaj.org/article/a43186bb4cd346d8948e060ed50b9538

A Novel Selective JAK2 Inhibitor Identified Using Pharmacological Interactions

Autor: Tony Eight Lin, Wei-Chun HuangFu, Min-Wu Chao, Tzu-Ying Sung, Chao-Di Chang, Yi-Ying Chen, Jui-Hua Hsieh, Huang-Ju Tu, Han-Li Huang, Shiow-Lin Pan, Kai-Cheng Hsu

Publikováno v: Frontiers in Pharmacology, Vol 9 (2018)

The JAK2/STAT signaling pathway mediates cytokine receptor signals that are involved in cell growth, survival and homeostasis. JAK2 is a member of the Janus kinase (JAK) family and aberrant JAK2/STAT is involved with various diseases, making the path

Externí odkaz: https://doaj.org/article/53feeaf4e47a4482ada47bbc6e155336

Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach

Autor: Kai Cheng Hsu, Tony Eight Lin, Liang Chieh Chen, Huang Ju Tu, Chia-Ron Yang, Min Wu Chao, Wei Chun HuangFu, Shiow Lin Pan, Tzu Ying Sung, Wei Jan Huang, Shih Chung Yen, Chao Di Chang

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
article-version (VoR) Version of Record
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 98-108 (2021)

The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa48ff72915f71f9bb552eb8d86b042f
http://europepmc.org/articles/PMC7655034

Isolation of anti-VEGF monoclonal antibodies with neutralizing effects from an Astragalus-induced immune antibody library

Autor: Tz Wen Yang, Fu Ling Chang, Hsien Te Huang, Chun Tang Chiou, Mei Kuang Lu, Tsai Yu Lin, Wang Chuan Chen, Chao Di Chang, Shiow Lin Pan, Keng-Chang Tsai, Yu Ching Lee, Chin Tien Chen

Publikováno v: International immunopharmacology. 88

The Astragalus membranaceus polysaccharides (APS) can improve immunity and enhance treatment reactions. This study analyzed the effects of effective antivascular endothelial growth factor (anti-VEGF) antibody production in mice treated with APS. Afte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a5391b1d83b990413c833e92c857b53
https://pubmed.ncbi.nlm.nih.gov/33182041