Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Chao, Jianping"'
Publikováno v:
In Steroids 2006 71(7):585-590
Akademický článek
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Autor:
Jay S. Fine, James Fossetta, Minglang Wu, Waldemar Gonsiorek, Carol Terminelli, Richard W. Bond, Daniel Lundell, J. Robert Merritt, Aki Cynthia J, Jianhua Chao, Zhenmin He, R. William Hipkin, James Jakway, Younong Yu, Taveras Arthur G, Diane Rindgen, Gaifa Lai, Rosemary Mayer-Ezel, Xuedong Fan, Michael P. Dwyer, Chao Jianping, Hongchen Qiu, Biju J. Purakkattle, Hong Bian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1318-1322
Comprehensive SAR studies were undertaken in the 3,4-diaminocyclobut-3-ene-1,2-dione class of CXCR2/CXCR1 receptor antagonists to explore the role of the heterocycle on chemokine receptor binding affinities, functional activity, as well as oral expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b68dac44b7899c04fed455963d2ae1a
https://doi.org/10.1016/j.bmcl.2008.01.024
https://doi.org/10.1016/j.bmcl.2008.01.024
Autor:
Kaiser Bernd, Aki Cynthia J, Rosemary Mayer-Ezel, Chao Jianping, R. William Hipkin, Richard W. Bond, Taveras Arthur G, Daniel Lundell, Jianhua Chao, Laura L. Rokosz, Purakkattle J. Biju, James Jakway, Viyyoor M. Girijavallabhan, Jay S. Fine, Tara M. Stauffer, James Fossetta, Wei Wang, Ge Li, Hong Bian, J. Robert Merritt, Waldemar Gonsiorek, Xuedong Fan, Baldwin John J, Michael P. Dwyer, Carol Terminelli, Younong Yu, Diane Rindgen, Lynne E. Ozgur
Publikováno v:
Journal of Medicinal Chemistry. 49:7603-7606
Structure-activity studies on lead cyclobutenedione 3 led to the discovery of 4 (SCH 527123), a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist with excellent cell-based activity. Compound 4 displayed good oral bioavailability in rat and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227efbb06ddac971383b73c48f410aca
https://doi.org/10.1021/jm0609622
https://doi.org/10.1021/jm0609622
Autor:
Kingsley H. Nelson, Lynne E. Ozgur, Laura L. Rokosz, Adriane E. Schilling, Taveras Arthur G, Wei Wang, Kaiser Bernd, Ge Li, Chao Jianping, Tara M. Stauffer, J. Robert Merritt, Baldwin John J, Michael P. Dwyer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4107-4110
A novel series of 3,4-diaminocyclobut-3-ene-1,2-diones was prepared and found to show potent inhibitory activity of CXCR2 binding and IL-8-mediated chemotaxis of a CXCR2-expressing cell line. Microsome stability and Caco2 studies were subsequently us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0652277caad793e3c206100797dfcfa4
https://doi.org/10.1016/j.bmcl.2006.04.082
https://doi.org/10.1016/j.bmcl.2006.04.082
Autor:
Lalwani Tarik, Patricia C. Weber, Paul Kirschmeier, Mark E. Snow, Ming Liu, Amin A. Nomeir, Linda James, Viyyoor M. Girijavallabhan, William T. Windsor, Robert Patton, Aki Cynthia J, Corey Strickland, Frank Hollinger, Doll Ronald J, Chao Jianping, Taveras Arthur G
Publikováno v:
Journal of Medicinal Chemistry. 45:3854-3864
The 10-bromobenzocycloheptapyridyl farnesyl transferase inhibitor (FTI) Sch-66336 (1) is currently under clinical evaluation for the treatment of human cancers. During structure-activity relationship development leading to 1, 10-bromobenzocycloheptap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519d505c7e685bc629614c709a3c3cf5
https://doi.org/10.1021/jm010463v
https://doi.org/10.1021/jm010463v
Autor:
Carmen S. Alvarez, Taveras Arthur G, Bancha Vibulbhan, Doll Ronald J, Viyyoor M. Girijavallabhan, Birendra N. Pramanik, Mathew S. Bryant, Donna Carr, Ashit K. Ganguly, Linda James, Alan K. Mallams, Chao Jianping, Adriano Afonso, Jeff Deskus, Ming Liu, Lynn Wang, Randall R. Rossman, Lalwani Tarik, Paul Kirschmeier, Cynthia J. Vaccaro, Larry Heimark, Stacy W. Remiszewski, F. George Njoroge, W. Robert Bishop, Robert Patton, Jocelyn del Rosario, Pat Pinto, and Amin A. Nomeir
Publikováno v:
Journal of Medicinal Chemistry. 42:2651-2661
Farnesyl protein transferase (FPT) is a promising target for the development of cancer chemotherapeutics because it is responsible for the farnesylation of oncogenic p21 Ras proteins which are found in nearly 30% of all human cancers and necessary fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc971c45283430967e751ea18ead34c3
https://doi.org/10.1021/jm990059k
https://doi.org/10.1021/jm990059k
Autor:
Xuedong Fan, Michael P. Dwyer, James Jakway, Aki Cynthia J, Daniel Lundell, Diane Rindgen, Jay S. Fine, Taveras Arthur G, J. Robert Merritt, Younong Yu, Biju J. Purakkattle, Chao Jianping, Jonathan E. Phillips, Michael Minnicozzi, James Fosetta, Jianhua Chao, William Hipkin
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(13)
A novel series of cyclobutenedione centered C(4)-alkyl substituted furanyl analogs was developed as potent CXCR2 and CXCR1 antagonists. Compound 16 exhibits potent inhibitory activities against IL-8 binding to the receptors (CXCR2 Ki=1 nM, IC(50)=1.3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520a0b8485fa54c20ee44e1739b30137
https://pubmed.ncbi.nlm.nih.gov/17459706
https://pubmed.ncbi.nlm.nih.gov/17459706
Autor:
Stacy Remiszewski, W. R. Bishop, Ronald J. Maplewood Doll, Randall R. Rossman, J. Desai, C. J. Aki, Corey Strickland, J. Deskus, P. Kirschmeier, Robert Patton, Mathew S. Bryant, Ronald Wolin, D. F. Rane, Carmen S. Alvarez, James Wang, J. del Rosario, Y. Liu, F. G. Njoroge, John D. Kelly, Donna Carr, Amin A. Nomeir, P. Pinto, B. Vibulbhan, Cooper Alan B, Adriano Afonso, Ming Liu, Linda James, Michael Connolly, V. Girijavallabhan, Patricia C. Weber, Chao Jianping, A. K. Ganguly, Alan K. Mallams, Lynn Wang, Arthur G. Taveras
Publikováno v:
Anticancer Agents ISBN: 9780841237452
Anticancer Agents: Frontiers in Cancer Chemotherapy
Anticancer Agents: Frontiers in Cancer Chemotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4b7cd535d2226118db7c5197f319cee
https://doi.org/10.1021/bk-2001-0796.ch013
https://doi.org/10.1021/bk-2001-0796.ch013
Autor:
Aki, Cynthia, Chao, Jianping, Ferreira, Johan A., Dwyer, Michael P., Yu, Younong, Chao, Jianhua, Merritt, Robert J., Lai, Gaifa, Wu, Minglang, Hipkin, R. William, Fan, Xuedong, Gonsiorek, Waldemar, Fosseta, James, Rindgen, Diane, Fine, Jay, Lundell, Daniel, Taveras, Arthur G., Biju, Purakkattle
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 August 2009 19(15):4446-4449