Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Chantale T. Guy"'
Autor:
Sachin Thigale, Daniel Baird, Chantale T. Guy, Jeffrey Hewett, Veronique Darsigny, Palermo Mark G, Louis Wang, Elizabeth George, Wilhelm A. Weihofen, Christopher M. Adams, Laryssa Tierney, Daniel S. Palacios, Erik Meredith, Toshio Kawanami, Xin Chen
Publikováno v:
ACS Med Chem Lett
[Image: see text] Small molecules that inhibit the metabolic enzyme NAMPT have emerged as potential therapeutics in oncology. As part of our effort in this area, we took a scaffold morphing approach and identified 3-pyridyl azetidine ureas as a poten
Autor:
Jeffrey Hewett, Daniel Baird, Chantale T. Guy, Toshio Kawanami, Scott A. Busby, Nicole White, Veronique Darsigny, Erin Geno, Geoffrey Boynton, Ming Yin, Palermo Mark G, Sachin Thigale, Elizabeth George, Upendra A. Argikar, Xin Chen, Louis Wang, Laryssa Tierney, Christopher M. Adams, Daniel S. Palacios, Erik Meredith, Wilhelm A. Weihofen
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(3)
Nicotinamide phosphoribosyltransferase is a key metabolic enzyme that is a potential target for oncology. Utilizing publicly available crystal structures of NAMPT and in silico docking of our internal compound library, a NAMPT inhibitor, 1, obtained
Autor:
Christophe Antczak, Chantale T. Guy, Ulrich Schopfer, Dorothea Haasen, Florian Fuchs, Paul Selzer
Publikováno v:
Assay and drug development technologies. 15(6)
Since 2011, phenotypic screening has been a trend in the pharmaceutical industry as well as in academia. This renaissance was triggered by analyses that suggested that phenotypic screening is a superior strategy to discover first-in-class drugs. Desp
Autor:
Chantale T. Guy, Markus Schirle, Bertran Gerrits, David Estoppey, Xuewen Pan, Jason R. Thomas, Malini Varadarajan, Annick Waldt, Gregory McAllister, Jeffrey Hewett, Kevin Xie, Nadire Ramadan, Sven Schuierer, Guglielmo Roma, Judith Knehr, Elizabeth Frias, Qiong Wang, Zinger Yang, Tewis Bouwmeester, Alicia Lindeman, John S. Reece-Hoyes, Walter Carbone, Edmund Harrington, Dominic Hoepfner, Carsten Russ, Xin Chen, Rachel Cuttat, Gregory R. Hoffman
Publikováno v:
Scientific Reports, 7
Scientific Reports
Scientific Reports
Scientific Reports, 7
ISSN:2045-2322
ISSN:2045-2322
Autor:
Christian N. Parker, Chantale T. Guy, Ansgar Schuffenhauer, Reinhardt Juergen, Hanspeter Nick, Vic E. Myer, Douglas W. Selinger, Felix Freuler, Alan Buckler, Thibault Varin, Marie-Cecile Didiot, Jeffrey Hewett
Publikováno v:
SLAS Discovery. 18:407-419
Translation initiation is a fine-tuned process that plays a critical role in tumorigenesis. The use of small molecules that modulate mRNA translation provides tool compounds to explore the mechanism of translational initiation and to further validate
Publikováno v:
Journal of Biological Chemistry. 271:9567-9572
With sequence homology to the SV40 T antigen-binding domain of the retinoblastoma protein (Rb), p107 and p130 constitute two additional members of the Rb family. To explore the potential function of p130 in mouse development, we cloned the full-lengt
Publikováno v:
Molecular and Cellular Biology. 12:954-961
The effect of mammary gland-specific expression of the polyomavirus middle T antigen was examined by establishing lines of transgenic mice that carry the middle T oncogene under the transcriptional control of the mouse mammary tumor virus promoter/en
Autor:
Carlos Garcia-Echeverria, Alan Buckler, Joseph Schoepfer, Cornelia Quadt, Chantale T. Guy, Robert Cozens, Patrick Chène, Thomas Radimerski, Andrew Massey, Josef Brueggen, Martin J. Drysdale, Michael Rugaard Jensen
Publikováno v:
Breast Cancer Research : BCR
Introduction Heat shock protein 90 (HSP90) is a key component of a multichaperone complex involved in the post-translational folding of a large number of client proteins, many of which play essential roles in tumorigenesis. HSP90 has emerged in recen
Autor:
Chantale T. Guy, Gizela Cardoso
Cancer is a prevalent and poorly understood disease in human populations. It is generally viewed as a complex, genetic, multistep process involving a series of independent events, each of which creates an incremental phenotypic aberration. For exampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30093c0bb9dfca616c64ede78dfb9bb5
https://doi.org/10.1385/1-59259-137-x:231
https://doi.org/10.1385/1-59259-137-x:231
Autor:
Mark Labow, Ieuan Clay, Jason Borawski, Louis Wang, Martin Gosling, Stephanie Fitzgerald, Elizabeth George, Christopher Rothwell, Jonathan Baffoe, Sarah Lilley, M. Oana Popa, Mohamed Bentires-Alj, Hedaythul Choudhury, Chantale T. Guy, Kristie Wetzel, Anke Bill, Michael Rebhan, Pichai Raman, L. Alex Gaither, Adrian Britschgi, Stephan Duss, Heike Brinkhaus
Publikováno v:
Cancer Research. 73:LB-205
Genomic alterations are the underlining cause of many human cancers: Amplified and overexpressed genes can drive neoplastic transformation and become essential survival factors for cancer cells. Thus, they represent promising targets for anti-cancer