Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3.

Autor: Ligen Lin, Keyun Chen, Waed Abdel Khalek, Jack Lee Ward, Henry Yang, Béatrice Chabi, Chantal Wrutniak-Cabello, Qiang Tong

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e85636 (2014)

We have previously reported that the expression of mitochondrial deacetylase SIRT3 is high in the slow oxidative muscle and that the expression of muscle SIRT3 level is increased by dietary restriction or exercise training. To explore the function of

Externí odkaz: https://doaj.org/article/a07e0d10e53643fda8d1e0a15616b9e1

SIRT3, a mitochondrial NAD⁺-dependent deacetylase, is involved in the regulation of myoblast differentiation.

Autor: Waed Abdel Khalek, Fabienne Cortade, Vincent Ollendorff, Laure Lapasset, Lionel Tintignac, Béatrice Chabi, Chantal Wrutniak-Cabello

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114388 (2014)

Sirtuin 3 (SIRT3), one of the seven mammalian sirtuins, is a mitochondrial NAD+-dependent deacetylase known to control key metabolic pathways. SIRT3 deacetylases and activates a large number of mitochondrial enzymes involved in the respiratory chain,

Externí odkaz: https://doaj.org/article/f08bb3b5cf6d4cb58ca304cab8391558

p43, a Truncated Form of Thyroid Hormone Receptor α, Regulates Maturation of Pancreatic β Cells

Autor: Christine Feillet-Coudray, Charles Coudray, Christelle Bertrand-Gaday, Laurence Pessemesse, François Casas, Emilie Blanchet, Chantal Wrutniak Cabello

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 2489, p 2489 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 5
International Journal of Molecular Sciences, MDPI, 2021, 22 (5), ⟨10.3390/ijms22052489⟩

International audience; P43 is a truncated form of thyroid hormone receptor alpha localized in mitochondria, which stimulates mitochondrial respiratory chain activity. Previously, we showed that deletion of p43 led to reduction of pancreatic islet de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7eb9ccd305ffa81093191d407e812a
https://www.mdpi.com/1422-0067/22/5/2489

Chicoric acid is an antioxidant molecule that stimulates AMP kinase pathway in L6 myotubes and extends lifespan in Caenorhabditis elegans.

Autor: Audrey Schlernitzauer, Catherine Oiry, Raphael Hamad, Simon Galas, Fabienne Cortade, Béatrice Chabi, François Casas, Laurence Pessemesse, Gilles Fouret, Christine Feillet-Coudray, Gérard Cros, Gérard Cabello, Richard Magous, Chantal Wrutniak-Cabello

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e78788 (2013)

Chicoric acid (CA) is a caffeoyl derivative previously described as having potential anti-diabetic properties. As similarities in cellular mechanism similarities between diabetes and aging have been shown, we explored on L6 myotubes the effect of CA

Externí odkaz: https://doaj.org/article/9fbe13c8d1bc4caab328b1b67292dbbb

Overexpression of the mitochondrial T3 receptor induces skeletal muscle atrophy during aging.

Autor: François Casas, Laurence Pessemesse, Stéphanie Grandemange, Pascal Seyer, Olivier Baris, Naïg Gueguen, Christelle Ramonatxo, Florence Perrin, Gilles Fouret, Laurence Lepourry, Gérard Cabello, Chantal Wrutniak-Cabello

Publikováno v: PLoS ONE, Vol 4, Iss 5, p e5631 (2009)

In previous studies, we characterized a new hormonal pathway involving a mitochondrial T3 receptor (p43) acting as a mitochondrial transcription factor. In in vitro and in vivo studies, we have shown that p43 increases mitochondrial transcription and

Externí odkaz: https://doaj.org/article/322b5a74134a474e8644fc922386da0a