Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Chantal Pont"'
Autor:
Esmee Koedoot, Michiel Fokkelman, Vasiliki-Maria Rogkoti, Marcel Smid, Iris van de Sandt, Hans de Bont, Chantal Pont, Janna E. Klip, Steven Wink, Mieke A. Timmermans, Erik A. C. Wiemer, Peter Stoilov, John A. Foekens, Sylvia E. Le Dévédec, John W. M. Martens, Bob van de Water
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Triple-negative breast cancers (TNBC) have enhanced migratory behaviour. Here, the authors perform a phenotypic imaging-based RNAi screen to identify several genes associated with regulation of migratory phenotypes and show that one of the regulators
Externí odkaz:
https://doaj.org/article/720606fcf5f54cc0ae38a7db6f491bec
Autor:
Carla S Verissimo, Rachel Elands, Sou Cheng, Dirk-Jan Saaltink, Judith P ter Horst, Maria N Alme, Chantal Pont, Bob van de Water, Bjarte Håvik, Carlos P Fitzsimons, Erno Vreugdenhil
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75752 (2013)
Doublecortin-like (DCL) is a microtubule-binding protein crucial for neuroblastoma (NB) cell proliferation. We have investigated whether the anti-proliferative effect of DCL knockdown is linked to reduced mitochondrial activity. We found a delay in t
Externí odkaz:
https://doaj.org/article/7c3a58d47ee84c3e830b551ad871b99b
Autor:
Lukas S. Wijaya, Steven J. Kunnen, Panuwat Trairatphisan, Ciaran Fisher, Meredith E. Crosby, Kai Schaefer, Karen Bodie, Erin E. Vaughan, Laura Breidenbach, Thomas Reich, Diana Clausznitzer, Sylvestre A. Bonnet, Sipeng Zheng, Chantal Pont, James L. Stevens, Sylvia Le Dévédec, Bob van de Water
Nephrotoxicity caused by drug or chemical exposure involves different mechanisms and nephron segments as well as a complex temporal integration of injury and repair responses. Distinct cellular transcriptional programs regulate the time-dependent tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a010a32e7cac4a8215400f4e8e5f883b
https://doi.org/10.1101/2023.01.03.522568
https://doi.org/10.1101/2023.01.03.522568
Autor:
Sylvia E. Le Dévédec, Michiel Fokkelman, Anna. M. Timmermans, Chantal Pont, John W.M. Martens, John A. Foekens, Bob van de Water, Peter Stoilov, Marcel Smid, Hans de Bont, Erik A.C. Wiemer, Iris van de Sandt, Janna E. Klip, Vasiliki-Maria Rogkoti, Esmee Koedoot, Steven Wink
Publikováno v:
Nature Communications, 10(1), 2983
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, 10:2983. Nature Publishing Group
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, 10:2983. Nature Publishing Group
Nature Communications
Ttriple-negative breast cancer (TNBC) is an aggressive and highly metastatic breast cancer subtype. Enhanced TNBC cell motility is a prerequisite of TNBC cell dissemination. Here, we apply an imaging-based RNAi phenotypic cell migration screen using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2feece2f0728cd7c3f55eb14a625e103
http://hdl.handle.net/1887/79045
http://hdl.handle.net/1887/79045
Autor:
Erik A.C. Wiemer, Peter Stoilov, Iris van de Sandt, John W.M. Martens, Sylvia E. Le Dévédec, Esmee Koedoot, Vasiliki-Maria Rogkoti, John A. Foekens, Janna E. Klip, Marcel Smid, Michiel Fokkelman, Hans de Bont, Chantal Pont, Bob van de Water
Metastasis is the major cause of death in cancer patients and migration of cancer cells from the primary tumor to distant sites is the prerequisite of metastasis formation. Here we applied an imaging-based RNAi phenotypic cell migration screen using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6495327fc31379d44c0ad8e4d5f5ae94
https://doi.org/10.1101/479568
https://doi.org/10.1101/479568
Autor:
Lynn Wester, Marjo de Graauw, Tamar Geiger, John W.M. Martens, Yinghui Zhang, Chantal Pont, Bob van de Water, Jean A. Helmijr, Maurice P.H.M. Jansen, Maxime P. Look, Marja Moerkens, Caroline H M van Deurzen, John H. N. Meerman, Els M.J.J. Berns, Erik H.J. Danen, Mieke M. Timmermans, Ram Siddappa, Jichao He
Publikováno v:
Oncogene, 37(14), 1869-1884. Nature Publishing Group
Antiestrogen resistance in estrogen receptor positive (ER+) breast cancer is associated with increased expression and activity of insulin-like growth factor 1 receptor (IGF1R). Here, a kinome siRNA screen has identified 10 regulators of IGF1R-mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474be77ac75a490aa422f25e9f8034a7
https://hdl.handle.net/1887/3202823
https://hdl.handle.net/1887/3202823
Autor:
Catherine Kirsanova, Marcel Smid, John A. Foekens, Sylvia E. Le Dévédec, Wies van Roosmalen, Maxime P. Look, Ofra Golani, Bob van de Water, Marjo de Graauw, Di Zi, John W.M. Martens, Peter A C 't Hoen, Annemieke M. Timmermans, Chantal Pont, Gabriella Rustici, Irina Pulyakhina, Suha Naffar-Abu-Amara, Benjamin Geiger
Publikováno v:
Journal of Clinical Investigation, 125(4), 1648-1664
Journal of Clinical Investigation, 125(4), 1648-1664. The American Society for Clinical Investigation
Journal of Clinical Investigation, 125(4), 1648-1664. The American Society for Clinical Investigation
Tumor cell migration is a key process for cancer cell dissemination and metastasis that is controlled by signal-mediated cytoskeletal and cell matrix adhesion remodeling. Using a phagokinetic track assay with migratory H1299 cells, we performed an si
Autor:
Christine L E Siezen, Bas ter Braak, Bob van de Water, Steven Wink, Esmee Koedoot, Jan Willem van der Laan, Chantal Pont
Publikováno v:
Breast cancer research
Breast cancer research, 17, 97. BioMed Central
Breast Cancer Research : BCR
Breast cancer research, 17, 97. BioMed Central
Breast Cancer Research : BCR
Introduction Insulin analogues are designed to have improved pharmacokinetic parameters compared to regular human insulin. This provides a sustained control of blood glucose levels in diabetic patients. All novel insulin analogues are tested for thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36ca27b1a8202ab95802a48660d21201
https://doi.org/10.1186/s13058-015-0600-5
https://doi.org/10.1186/s13058-015-0600-5
Publikováno v:
Biochemical Pharmacology. 71:268-277
Glutathione S-transferase pi (GST, E.C.2.5.1.18) overexpression contributes to resistance of cancer cells towards cytostatic drugs. Furthermore, GSTpi is involved in the cellular stress response through inhibition of Jun N-terminal-kinase (JNK), a pr
Autor:
Bob van de Water, Erno Vreugdenhil, Maria Nordheim Alme, Bjarte Håvik, Rachel J. J. Elands, Judith P. ter Horst, Carlos P. Fitzsimons, Dirk-Jan Saaltink, Carla S Verissimo, Sou Cheng, Chantal Pont
Publikováno v:
PLoS ONE, 8(9)
PLoS ONE, 8(9), e75752
PLoS ONE
PLoS ONE, Vol 8, Iss 9, p e75752 (2013)
PLoS ONE, 8(9):e75752. Public Library of Science
PLoS ONE, 8(9), e75752
PLoS ONE
PLoS ONE, Vol 8, Iss 9, p e75752 (2013)
PLoS ONE, 8(9):e75752. Public Library of Science
Doublecortin-like (DCL) is a microtubule-binding protein crucial for neuroblastoma (NB) cell proliferation. We have investigated whether the anti-proliferative effect of DCL knockdown is linked to reduced mitochondrial activity. We found a delay in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50be6a5fef698f396c131594eaaef3b4
https://doi.org/10.1371/journal.pone.0075752
https://doi.org/10.1371/journal.pone.0075752