Prion replication occurs in endogenous adult neural stem cells and alters their neuronal fate: involvement of endogenous neural stem cells in prion diseases.

Autor: Aroa Relaño-Ginès, Audrey Gabelle, Claire Hamela, Maxime Belondrade, Danielle Casanova, Chantal Mourton-Gilles, Sylvain Lehmann, Carole Crozet

Publikováno v: PLoS Pathogens, Vol 9, Iss 8, p e1003485 (2013)

Prion diseases are irreversible progressive neurodegenerative diseases, leading to severe incapacity and death. They are characterized in the brain by prion amyloid deposits, vacuolisation, astrocytosis, neuronal degeneration, and by cognitive, behav

Externí odkaz: https://doaj.org/article/1650d12fd8564677b0b7376c1c8382dc

Point-of-care diagnostics for ricin exposure

Autor: Chantal Mourton-Gilles, Dorothée Jary, Jean Berthier, Cathy Philippe, Mohamed Lemine Youba Diakite, Jérôme Rollin, Didier Sauvaire, Guillaume Delapierre, Xavier Gidrol

Publikováno v: Lab on a Chip
Lab on a Chip, Royal Society of Chemistry, 2015, 15 (10), pp.2308-2317. ⟨10.1039/c5lc00178a⟩
Lab on a Chip, 2015, 15 (10), pp.2308-2317. ⟨10.1039/c5lc00178a⟩

A long-sought milestone in the defense against bioterrorism is the development of rapid, simple, and near-patient assays for diagnostic and theranostic purposes. Here, we present a powerful test based on a host response to a biological weapon agent,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e45b2e3561a1f640897c5c1ad397fc0
https://hal.archives-ouvertes.fr/hal-02109816

Prion replication occurs in endogenous adult neural stem cells and alters their neuronal fate: involvement of endogenous neural stem cells in prion diseases

Autor: Claire Hamela, Carole Crozet, Danielle Casanova, Maxime Belondrade, Chantal Mourton-Gilles, Aroa Relano-Gines, Sylvain Lehmann, Audrey Gabelle

Publikováno v: PLoS Pathogens, Vol 9, Iss 8, p e1003485 (2013)
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2013, 9 (8), pp.e1003485. ⟨10.1371/journal.ppat.1003485⟩
PLoS Pathogens, 2013, 9 (8), pp.e1003485. ⟨10.1371/journal.ppat.1003485⟩

Prion diseases are irreversible progressive neurodegenerative diseases, leading to severe incapacity and death. They are characterized in the brain by prion amyloid deposits, vacuolisation, astrocytosis, neuronal degeneration, and by cognitive, behav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::169c31b9dd275d122ae767880af7d6c3
http://europepmc.org/articles/PMC3731238?pdf=render

New immunoassay for the mapping of neurofibrillary degeneration in Alzheimer's disease using two monoclonal antibodies against human paired helical filament tau proteins

Autor: Valérie Buée-Scherrer, A. Wattez, Olivier Condamines, André Delacourte, Laurence Boissier, Chantal Mourton-Gilles, Bernard Pau

Publikováno v: Neuroscience Letters. 192:81-84

Monoclonal antibodies against human paired helical filament tau (PHF-tau) proteins were produced. Two of these antibodies, AD1 and AD2, were shown by immunoblot to be directed against distinct hyperphosphorylated epitopes of the PHF-tau proteins. Usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ffe92988ddd7a46dee6f97f7b22985
https://doi.org/10.1016/0304-3940(95)11617-6

Toxic Effects of Intracerebral PrP Antibody Administration During the Course of BSE Infection in Mice

Autor: Corinne Ida Lasmézas, Elisabeth Kremmer, Pierluigi Gambetti, Jacques Grassi, Sabine Gilch, Thierry Baron, Cécile Féraudet, Nicole Salès, Chantal Mourton Gilles, Hermann M. Schätzl, Wen-Quan Zou, Maxime Lefebvre-Roque

Publikováno v: Prion
Prion, Taylor & Francis, 2007, 1 (3), pp.198-206
Prion, 2007, 1 (3), pp.198-206

The absence of specific immune response is a hallmark of prion diseases. However, in vitro and in vivo experiments have provided evidence that an anti-PrP humoral response could have beneficial effects. Prophylactic passive immunization performed at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32aac3d1074ae93f8e688fdec1ca21eb
https://europepmc.org/articles/PMC2634593/