Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Chantal Mahon"'
Autor:
Steven V. Fox, Kate Mostoller, Steve Warrington, Chris Min, Caroline Cilissen, Marion Wittmann, Douglas C. Beshore, Dawn Harris, Henry S. Lange, Natasa Pajkovic, Jason M. Uslaner, Chantal Mahon, Scott D. Kuduk
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 365:556-566
The current standard of care for treating Alzheimer's disease is acetylcholinesterase inhibitors, which nonselectively increase cholinergic signaling by indirectly enhancing activity of nicotinic and muscarinic receptors. These drugs improve cognitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21df26582717ec1aa725263055cd8e11
https://doi.org/10.1124/jpet.117.245894
https://doi.org/10.1124/jpet.117.245894
Autor:
Michael F. Crutchlow, Linda Morrow, Michael C. Marcos, Kate Mostoller, Chantal Mahon, April M. Barbour, Elaine Watkins, John Palcza, Yang Xu, Marcus Hompesch
Publikováno v:
Diabetes, Obesity and Metabolism. 20:400-408
Aims MK-1293 is an insulin glargine that has an identical amino acid sequence to that of Lantus, the originator insulin glargine. Two euglycemic clamp studies, one in subjects with Type 1 diabetes (T1D) and one in healthy subjects, were conducted to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3b722cbaad1892b2878a7e1008ea020
https://doi.org/10.1111/dom.13084
https://doi.org/10.1111/dom.13084
Autor:
Chengcheng Liu, Maria Gutierrez, Christine Brandquist, S. Aubrey Stoch, Deborah Panebianco, Kate Mostoller, Jacqueline B. McCrea, Stefan Zajic, Chantal Mahon, Manu Chakravarthy, Fang Liu
Publikováno v:
Clinical pharmacology in drug developmentReferences. 8(7)
Assessing risk for QTc interval prolongation in a thorough QTc study is a standard recommendation when evaluating new chemical entities. As part of the clinical development program for odanacatib, an oral selective inhibitor of cathepsin K previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fa14f2fa3f5161bdc17cde22aa63ec6
https://pubmed.ncbi.nlm.nih.gov/31175709
https://pubmed.ncbi.nlm.nih.gov/31175709
Autor:
Jason M, Uslaner, Scott D, Kuduk, Marion, Wittmann, Henry S, Lange, Steve V, Fox, Chris, Min, Natasa, Pajkovic, Dawn, Harris, Caroline, Cilissen, Chantal, Mahon, Kate, Mostoller, Steve, Warrington, Douglas C, Beshore
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 365(3)
The current standard of care for treating Alzheimer's disease is acetylcholinesterase inhibitors, which nonselectively increase cholinergic signaling by indirectly enhancing activity of nicotinic and muscarinic receptors. These drugs improve cognitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1289b39b58405a6af4a2971608932265
https://pubmed.ncbi.nlm.nih.gov/29563325
https://pubmed.ncbi.nlm.nih.gov/29563325
Autor:
Christopher Lines, M. Gail Murphy, Chantal Mahon, John J. Renger, Hong Sun, John A. Wagner, Kate Mostoller, W. Joseph Herring, Catherine MacLeod, Gary G. Kay, Lingling Han, Valerie Schulz, Junshui Ma, Kevin R. Brown, Laura B. Rosen
Publikováno v:
The Journal of Clinical Pharmacology. 53:1294-1302
Histaminergic neurons are regulators of the sleep-wake cycle. We evaluated the alerting effects of MK-7288 (10, 20 mg), a novel histamine-3 receptor inverse agonist (H3RIA), along with modafinil (200 mg), a standard treatment, in a randomized, double
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::691bde734118828ca575e167420b3290
https://doi.org/10.1002/jcph.182
https://doi.org/10.1002/jcph.182
Autor:
Chantal Mahon, Terence G. Hamill, K Butterfield, Guy Bormans, John A. Wagner, Michel Koole, Fang Liu, J De Hoon, Richard Hargreaves, P Zappacosta, I De Lepeleire, P. D Mozley, Ruben Declercq, W Xie, Yang Liu, Inge Derdelinckx, K. Van Laere, M. G Murphy, Laura B. Rosen, Daniel Tatosian, Craig R. Shadle, S M Sanabria Bohorquez
Publikováno v:
Clinical Pharmacology & Therapeutics. 92:243-250
The type 1 neurokinin receptor (NK1R) antagonist aprepitant and its i.v. prodrug fosaprepitant have been approved for prevention of acute and delayed nausea and vomiting associated with chemotherapy. This study evaluated the magnitude and duration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454387a449b7c57da686bdcb529ca993
https://doi.org/10.1038/clpt.2012.62
https://doi.org/10.1038/clpt.2012.62
Autor:
Kelem Kassahun, Anish Mehta, Christopher R. Gibson, Kate Mostoller, David Hreniuk, Chengcheng Liu, Raymond Evers, Stefan Zajic, Chantal Mahon, Denise Morris, Eugene E. Marcantonio, Jairam Palamanda, Cuyue Tang, S. Aubrey Stoch, Jeanine E. Ballard, John A. Wagner
Publikováno v:
Journal of clinical pharmacology. 54(11)
We evaluated the effect of prednisone on midazolam and odanacatib pharmacokinetics. In this open-label, 2-period crossover study in healthy male subjects, midazolam 2 mg was administered (Day -1) followed by odanacatib 50 mg (Day 1) during Part 1. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f068493b9bf03695f523576782930c8d
https://pubmed.ncbi.nlm.nih.gov/24895078
https://pubmed.ncbi.nlm.nih.gov/24895078
Autor:
S. Aubrey Stoch, Kate Mostoller, Anish Mehta, Jessie Lee, Stefan Zajic, Chantal Mahon, Matt S. Anderson, Denise Morris, Chengcheng Liu, Steven Jeffers, I.N. Gendrano
Publikováno v:
The Journal of clinical endocrinology and metabolism. 99(2)
Odanacatib is a cathepsin K inhibitor in development for the treatment of osteoporosis. Evaluation of therapies to ensure that treatment effects are relevant regardless of sex is clinically important.In this double-blind, randomized controlled trial,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d5cbb5e13301b7146e07694fffeb2c
https://pubmed.ncbi.nlm.nih.gov/24276460
https://pubmed.ncbi.nlm.nih.gov/24276460
Autor:
Hong, Sun, Catherine, MacLeod, Kate, Mostoller, Chantal, Mahon, Lingling, Han, John J, Renger, Junshui, Ma, Kevin R, Brown, Valerie, Schulz, Gary G, Kay, W Joseph, Herring, Christopher, Lines, Laura B, Rosen, M Gail, Murphy, John A, Wagner
Publikováno v:
Journal of clinical pharmacology. 53(12)
Histaminergic neurons are regulators of the sleep-wake cycle. We evaluated the alerting effects of MK-7288 (10, 20 mg), a novel histamine-3 receptor inverse agonist (H3RIA), along with modafinil (200 mg), a standard treatment, in a randomized, double
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b75bcfcc9306522d45d2d1aa12589877
https://pubmed.ncbi.nlm.nih.gov/24122944
https://pubmed.ncbi.nlm.nih.gov/24122944