Výsledky vyhledávání - "Chantal Lummen"

The p38 MAP kinase inhibitor SB203580 enhances nuclear factor-kappa B transcriptional activity by a non-specific effect upon the ERK pathway

Autor: Leonore Tuyt, KU Birkenkamp, Albertus T. J. Wierenga, Wiebe Kruijer, Chantal Lummen, Edo Vellenga

Publikováno v: British Journal of Pharmacology. 131:99-107

In the present study we investigated a possible role for the p38 mitogen-activated protein (MAP) kinase pathway in mediating nuclear factor-kappa B (NF-kappaB) transcriptional activity in the erythroleukaemic cell line TF-1. TF-1 cells stimulated wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3befae29d3bce89fff4f5795ac1ce275
https://doi.org/10.1038/sj.bjp.0703534

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Extracellular-Regulated Kinase 1/2, Jun N-Terminal Kinase, and c-Jun Are Involved in NF-κB-Dependent IL-6 Expression in Human Monocytes

Autor: Leonore M. L. Tuyt, Wim H. A. Dokter, Kim Birkenkamp, Sicco B. Koopmans, Chantal Lummen, Wiebe Kruijer, Edo Vellenga

Publikováno v: The Journal of Immunology. 162:4893-4902

In the present study we investigated the possible involvement of the mitogen-activated protein kinase family members extracellular-regulated kinase 1/2 (ERK1/2) and c-Jun N-terminal kinase (JNK) in mediating IL-6 gene expression in human monocytes, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b825805f95eba944411b299320d392c
https://doi.org/10.4049/jimmunol.162.8.4893

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Differential Binding Activity of the Transcription Factor LIL-Stat in Immature and Differentiated Normal and Leukemic Myeloid Cells

Autor: Leonore Tuyt, W. H. A. Dokter, Chantal Lummen, Krista Bregman, Edo Vellenga

Publikováno v: Blood, 92(4), 1364-1373. AMER SOC HEMATOLOGY

Cytokines and growth factors induce activation of the family of signal transducers and activators of transcription (Stats) that directly activate gene expression. Recently, constitutively activated Stat1, Stat3, and Stat5 were identified in nuclear e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::338d1adbc4e32416b683baaeacfd2ab8
https://doi.org/10.1182/blood.v92.4.1364.416k34_1364_1373

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Regulation of p100 (NFKB2) expression in human monocytes in response to inflammatory mediators and lymphokines

Autor: H. De Wit, W. H. A. Dokter, J. W. Smit, M. Van Der Leij, Chantal Lummen, Edo Vellenga, S.B. Koopmans

Publikováno v: Leukemia, 12(3), 363-370. Nature Publishing Group

The transcription factor NF-KB plays an important role in the regulated expression of cytokines in human monocytes. A p100 subunit of NF-kappa B has I kappa B-like properties by sequestering the p65 transactivating subunit in the cytosol of cells. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfae51ba39cd590765692c64070bd4c
https://doi.org/10.1038/sj.leu.2400950

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