Výsledky vyhledávání - "Chantal Jouanno"

A CONVENIENT ACCES TO 1,7-DIFUNCTIONAL NAPHTHALENES: THE SYNTHESIS OF THE 1,7-DICARBALDEHYDE 7-MONODIMETHYLACETAL

Autor: René Grée, Chantal Jouanno, Yves Le Floc'h

Publikováno v: Bulletin des Sociétés Chimiques Belges. 104:49-53

An easily accessible route to the 1,7-dicarbaldehyde 7-monodimethylacetal 7 is described. It proceeds in a six step sequence from the known 7-methyl-l-tetralone.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5ffcb669a868411ea9f828a5d6419b3c
https://doi.org/10.1002/bscb.19951040109

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Amide-Modified Oligonucleotides with Preorganized Backbone and Furanose Rings: Highly Increased Thermodynamic Stability of the Duplexes Formed with their RNA and DNA Complements

Autor: Chantal Jouanno, Sebastian Wendeborn, Valérie Fritsch, Romain M. Wolf, Alain De Mesmaeker, Jacques Lebreton

Publikováno v: Synlett. 1997:1287-1290

The amide backbone modification C3'-CH2-CONH-C5' has been further modified by introducing a methyl at C5', either in R or in S configuration. Only the S stereoisomer can adopt the required geometry to fit into a duplex with complementary RNA. Additio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c40425666e5154494f6248145281b538
https://doi.org/10.1055/s-1997-1003

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Amide backbone modifications for antisense oligonucleotides carrying potential intercalating substituents: Influence on the thermodynamic stability of the corresponding duplexes with RNA- and DNA- complements

Autor: Chantal Jouanno, Alain De Mesmaeker, Valérie Fritsch, Romain M. Wolf, Sebastian Wendeborn

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:1869-1874

The synthesis of the amide dimers 3–5 carrying a potential intercalating substituent on the nitrogen atom of the backbone is presented, together with the incorporation of these modifications into oligonucleotides, the resulting melting temperatures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5ea8163dea05916f274d56efb25c86a
https://doi.org/10.1016/s0960-894x(97)00318-1

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Replacement of the phosphodiester linkage in oligonucleotides by an amide: Effect of backbone length on duplex stability with RNA complement

Autor: Romain M. Wolf, Alain De Mesmaeker, Sebastian Wendeborn, Chantal Jouanno

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:447-452

Five dimers containing amide linkages instead of the natural phosphodiester linkage were synthesized and incorporated into oligonucleotides. The length of the amide backbone was varied. The hybridization properties of the modified oligonucleotides wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b671ce350e569bbd16f5a76c8281939
https://doi.org/10.1016/s0960-894x(97)00037-1

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Replacement of the phosphodiester linkage in oligonucleotides by an acetylenic bond: Comparison between carbon-, sulfur-, and oxygen-containing analogs

Autor: Chantal Jouanno, Sebastian Wendeborn, Romain M. Wolf, Alain De Mesmaeker

Publikováno v: Tetrahedron Letters. 37:5511-5514

Four acetylene-containing dimers were synthesized and incorporated into oligonucleotides. The hybridization properties of the modified oligonucleotides to RNA complements and their conformational analysis are reported.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb933012a2cd38ab24b9325e5892bd9f
https://doi.org/10.1016/0040-4039(96)01164-1

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