Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Chantal J. M. van Opbergen"'
Autor:
Chantal J. M. van Opbergen, Joseph Sall, Chris Petzold, Kristen Dancel-Manning, Mario Delmar, Feng-Xia Liang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Previous studies revealed an abundance of functional Connexin43 (Cx43) hemichannels consequent to loss of plakophilin-2 (PKP2) expression in adult murine hearts. The increased Cx43-mediated membrane permeability is likely responsible for excess entry
Externí odkaz:
https://doaj.org/article/02fb3793e1a549d89a48b5314d9a8268
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Background: Patients with arrhythmogenic cardiomyopathy may suffer from lethal ventricular arrhythmias. Arrhythmogenic cardiomyopathy is predominantly triggered by mutations in plakophilin-2, a key component of cell-to-cell adhesion and calcium cycli
Externí odkaz:
https://doaj.org/article/bcb80fd8383e42678afc85f90beae7ce
Publikováno v:
Physiological Reviews. 103:2271-2319
The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via mechanical and electrical junctions. Although described in some detail by light microscopy in the 19th century, it was in 1966 that electron microscopy imag
Autor:
Marta Pérez-Hernández, Grecia M. Marrón-Liñares, Florencia Schlamp, Adriana Heguy, Chantal J. M. van Opbergen, Valeria Mezzano, Mingliang Zhang, Feng-Xia Liang, Marina Cerrone, Mario Delmar
Publikováno v:
Frontiers in Physiology, Vol 11 (2021)
Plakophilin-2 (PKP2) is classically defined as a component of the desmosome. Besides its role in cell–cell adhesion, PKP2 can modulate transcription through intracellular signals initiated at the site of cell–cell contact. Mutations in PKP2 assoc
Externí odkaz:
https://doaj.org/article/55c37e080cd946a5ac8f06f3881b2f9d
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Arrhythmogenic cardiomyopathy (ACM) is a familial heart disease, associated with ventricular arrhythmias, fibrofatty replacement of the myocardial mass and an increased risk of sudden cardiac death (SCD). Malignant ventricular arrhythmias and SCD lar
Externí odkaz:
https://doaj.org/article/9009373292e346f38c3cc739ee18015d
Autor:
Marina Cerrone, Chantal J. M. van Opbergen, Kabir Malkani, Natasha Irrera, Mingliang Zhang, Toon A. B. Van Veen, Bruce Cronstein, Mario Delmar
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Background: Mutations in plakophilin-2 (PKP2) are the most common cause of familial Arrhythmogenic Right Ventricular Cardiomyopathy, a disease characterized by ventricular arrhythmias, sudden death, and progressive fibrofatty cardiomyopathy. The rela
Externí odkaz:
https://doaj.org/article/f5a627630f244fd0941b340e862240b3
Autor:
Chantal J. M. van Opbergen, Joseph Sall, Chris Petzold, Kristen Dancel-Manning, Mario Delmar, Feng-Xia Liang
Publikováno v:
Frontiers in cell and developmental biology. 10
Previous studies revealed an abundance of functional Connexin43 (Cx43) hemichannels consequent to loss of plakophilin-2 (PKP2) expression in adult murine hearts. The increased Cx43-mediated membrane permeability is likely responsible for excess entry
Publikováno v:
Frontiers in physiology, 12:732573. Frontiers Media S.A.
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology
Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology
Background: Patients with arrhythmogenic cardiomyopathy may suffer from lethal ventricular arrhythmias. Arrhythmogenic cardiomyopathy is predominantly triggered by mutations in plakophilin-2, a key component of cell-to-cell adhesion and calcium cycli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0e8f543e119bc297b76a83ec478493
https://cris.maastrichtuniversity.nl/en/publications/a67e51de-3d94-4a90-8974-60b4ef17a9e9
https://cris.maastrichtuniversity.nl/en/publications/a67e51de-3d94-4a90-8974-60b4ef17a9e9
Autor:
Paul M.L. Janssen, Jeff S. Healey, Nara Sobriera, Hugh Calkins, Samantha L. Simmons, Sharon L. Graw, Peter J. Mohler, Mona El-Refaey, Robert W. Davies, Brittney Murray, Danna A. Spears, Kirti Mittal, Duy T. Nguyen, Jason D. Roberts, Crystal Tichnell, Maarten P. van den Berg, J. Peter van Tintelen, Nathaniel P. Murphy, Sara N. Koenig, Daniel P. Judge, Philip C. Ursell, Meriam Åström Aneq, Mei Han, Crystal F. Kline, Robert A. Hegele, Anna Gréen, Luisa Mestroni, Andrew D. Krahn, Robert M. Hamilton, Amy C. Sturm, Arthur A.M. Wilde, Babak Nazer, Frank I. Marcus, Gianfranco Sinagra, Michael H. Gollob, Alberto Codima, David A. Chiasson, Chantal J. M. van Opbergen, Matthew R.G. Taylor, Shabana Aafaqi, Cynthia A. James, Edgar T. Hoorntje, Martin J. Gardner, Tamara T. Koopmann, Ellen R. Lubbers, Meena Fatah, Anthony Tang, Hassan Musa, Muhammad Rafiq, Loren E. Wold, Allan C. Skanes, Thomas J. Hund, John F. Robinson, Melvin M. Scheinman, Elisabeth M. Lodder, Toon A.B. van Veen
Publikováno v:
Journal of Clinical Investigation, 129(8), 3171. The American Society for Clinical Investigation
The Journal of Clinical Investigation, 129(8), 3171-3184. AMER SOC CLINICAL INVESTIGATION INC
Journal of clinical investigation, 130, 3171-3184. The American Society for Clinical Investigation
The Journal of clinical investigation, vol 129, iss 8
The Journal of Clinical Investigation, 129(8), 3171-3184. AMER SOC CLINICAL INVESTIGATION INC
Journal of clinical investigation, 130, 3171-3184. The American Society for Clinical Investigation
The Journal of clinical investigation, vol 129, iss 8
Arrhythmogenic cardiomyopathy (ACM) is an inherited arrhythmia syndrome characterized by severe structural and electrical cardiac phenotypes, including myocardial fibrofatty replacement and sudden cardiac death. Clinical management of ACM is largely
Autor:
Marina Cerrone, Grecia M Marrón-Liñares, Chantal J M van Opbergen, Sarah Costa, Mimount Bourfiss, Marta Pérez-Hernández, Florencia Schlamp, Fabian Sanchis-Gomar, Kabir Malkani, Kamelia Drenkova, Mingliang Zhang, Xianming Lin, Adriana Heguy, Birgitta K Velthuis, Niek H J Prakken, Andre LaGerche, Hugh Calkins, Cynthia A James, Anneline S J M Te Riele, Mario Delmar
Publikováno v:
Eur Heart J
European Heart Journal, 43(12), 1251-1264. Oxford University Press
European Heart Journal, 43(12), 1251-1264. Oxford University Press
Aims Exercise increases arrhythmia risk and cardiomyopathy progression in arrhythmogenic right ventricular cardiomyopathy (ARVC) patients, but the mechanisms remain unknown. We investigated transcriptomic changes caused by endurance training in mice