Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Chantal Hellal-Levy"'
Autor:
Jérôme Fagart, Gilles Auzou, Marie-Edith Rafestin-Oblin, Jean-Marie Wurtz, Chantal Hellal-Levy, Anny Souque, Dino Moras
Publikováno v:
Molecular Pharmacology. 58:684-691
Sequence analysis revealed a strong homology between the ligand-binding domain (LBD) of the human mineralocorticoid receptor (hMR) and glucocorticoid receptor (hGR). Nevertheless, steroids with bulky C11-substituents bind to hGR, unlike hMR. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c8f8101b9f8462b98baa7f9fdfc6b4
https://doi.org/10.1124/mol.58.4.684
https://doi.org/10.1124/mol.58.4.684
Autor:
Jean-Marie Wurtz, Jérôme Fagart, Chantal Hellal-Levy, Marie-Edith Rafestin-Oblin, Anny Souque, Dino Moras
Publikováno v:
Molecular Endocrinology. 14:1210-1221
The crystal structures of ligand-free and agonist-associated ligand-binding domain (LBD) of nuclear receptors (NRs) reveal that the amphipathic helix H12 is folded back toward the LBD core in the agonist-associated conformation, allowing the binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056dfe9ccb93a64875ff3b0dc5fa4506
https://doi.org/10.1210/mend.14.8.0502
https://doi.org/10.1210/mend.14.8.0502
Publikováno v:
Journal de la Société de Biologie. 193:355-360
L’aldosterone et le cortisol, principales hormones mineralocorticoides et glucocorticoides chez l’Homme, ont des structures tres proches. Les deux hormones se lient au recepteur aux mineralocorticoides (RM) avec la meme affinite, neanmoins le RM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::650e89de05f63d167c82e2c618804c3a
https://doi.org/10.1051/jbio/1999193040355
https://doi.org/10.1051/jbio/1999193040355
Autor:
Chantal Hellal-Levy, Brigitte Lupo, Marie-Edith Rafestin-Oblin, Gilles Auzou, Stéphan Jalaguier, Brigitte Couette, Jérôme Fagart
Publikováno v:
Molecular Endocrinology. 12:855-863
The effects of aldosterone are mediated by the mineralocorticoid receptor (MR), a ligand-dependent transcription factor. We investigated the structural determinants for ligand binding to the receptor using a series of human MR (hMR) deletion mutants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21466f179e5c34fb638f3ed152f0957f
https://doi.org/10.1210/mend.12.6.0119
https://doi.org/10.1210/mend.12.6.0119
Autor:
Chantal Hellal-Levy, Brigitte Couette, Anny Souque, Celso E. Gomez-Sanchez, Marie-Edith Rafestin-Oblin, Jérôme Fagart
Publikováno v:
FEBS letters. 464(1-2)
The ligand binding domains of the human mineralocorticoid receptor (hMR) and glucocorticoid receptor (hGR) display a high sequence homology. Aldosterone and cortisol, the major mineralocorticoid and glucocorticoid hormones, are very closely related,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e857507cd89eead2435cc281792941e1
https://pubmed.ncbi.nlm.nih.gov/10611474
https://pubmed.ncbi.nlm.nih.gov/10611474
Autor:
Chantal Hellal-Levy, Jean-Marie Wurtz, Marie-Edith Rafestin-Oblin, Jérôme Fagart, Anny Souque, Dino Moras
Key residues of the human mineralocorticoid receptor (hMR) involved in the recognition of agonist and antagonist ligands were identified by alanine-scanning mutagenesis based on a homology model of the hMR ligand-binding domain. They were tested for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78fdc7b74b74e73c18a541330243dcd
https://europepmc.org/articles/PMC1170670/
https://europepmc.org/articles/PMC1170670/
Publikováno v:
Kidney International. (4):1250-1255
Mechanistic aspects of mineralocorticoid receptor activation. Aldosterone exerts its biological effects through binding to mineralocorticoid receptor (MR). Ligand binding induces a receptor transconformation within the ligand-binding domain and disso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f23f007f8dc58de29791d287330fde