Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Chantal Donovan"'
Autor:
Brian G Oliver, Xiaomin Huang, Rochelle Yarak, Xu Bai, Qi Wang, Razia Zakarya, Karosham D. Reddy, Chantal Donovan, Richard Y. Kim, James Morkaya, Baoming Wang, Yik Lung Chan, Sonia Saad, Alen Faiz, David van Reyk, Alexei Verkhratsky, Chenju Yi, Hui Chen
Publikováno v:
Environment International, Vol 191, Iss , Pp 108971- (2024)
There is no safe level of air pollution for human health. Traffic-related particulate matter (PM2.5) is a major in-utero toxin, mechanisms of action of which are not fully understood. BALB/c dams were exposed to an Australian level of traffic PM2.5 (
Externí odkaz:
https://doaj.org/article/6fca2a75557a4402bb948d62629d5789
Autor:
Jemma R Mayall, Jay C Horvat, Niamh E Mangan, Anne Chevalier, Huw McCarthy, Daniel Hampsey, Chantal Donovan, Alexandra C Brown, Antony Y Matthews, Nicole A de Weerd, Eveline D de Geus, Malcolm R Starkey, Richard Y Kim, Katie Daly, Bridie J Goggins, Simon Keely, Steven Maltby, Rennay Baldwin, Paul S Foster, Michael J Boyle, Pradeep S Tanwar, Nicholas D Huntington, Paul J Hertzog, Philip M Hansbro
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 2, Pp 267-293 (2024)
Abstract The uterus is a unique mucosal site where immune responses are balanced to be permissive of a fetus, yet protective against infections. Regulation of natural killer (NK) cell responses in the uterus during infection is critical, yet no studi
Externí odkaz:
https://doaj.org/article/27c077dad3a5489b8adb434699dbf324
Autor:
Jay C. Horvat, Richard Y. Kim, Natasha Weaver, Christopher Augood, Alexandra C. Brown, Chantal Donovan, Pierrick Dupre, Lakshitha Gunawardhana, Jemma R. Mayall, Nicole G. Hansbro, Avril A. B. Robertson, Luke A. J. O’Neill, Matthew A. Cooper, Elizabeth G. Holliday, Philip M. Hansbro, Peter G. Gibson
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Increased airway NLRP3 inflammasome-mediated IL-1β responses may underpin severe neutrophilic asthma. However, whether increased inflammasome activation is unique to severe asthma, is a common feature of immune cells in all infla
Externí odkaz:
https://doaj.org/article/60288ffe24fd40148d0b5a1960f9d444
Autor:
Priyanka Sahu, Chantal Donovan, Keshav Raj Paudel, Sophie Pickles, Vrushali Chimankar, Richard Y. Kim, Jay C. Horvart, Kamal Dua, Antonio Ieni, Francesco Nucera, Helle Bielefeldt-Ohmann, Sarah Mazilli, Gaetano Caramori, J. Guy Lyons, Philip M. Hansbro
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Primary lung carcinoma or lung cancer (LC) is classified into small-cell or non-small-cell (NSCLC) lung carcinoma. Lung squamous cell carcinoma (LSCC) is the second most common subtype of NSCLC responsible for 30% of all LCs, and its survival remains
Externí odkaz:
https://doaj.org/article/b3a0684f86d348c3918d4772d5cf4d2b
Autor:
Xiaofan Tu, Henry M. Gomez, Richard Y. Kim, Alexandra C. Brown, Emma de Jong, Izabela Galvao, Alen Faiz, Anthony Bosco, Jay C. Horvat, Philip Hansbro, Chantal Donovan
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Lung transcriptomics studies in asthma have provided valuable information in the whole lung context, however, deciphering the individual contributions of the airway and parenchyma in disease pathogenesis may expedite the development of novel
Externí odkaz:
https://doaj.org/article/911ea9c2ab394ba2934f8c80d24c27d0
Autor:
Theodore S. Kapellos, Kevin Baßler, Wataru Fujii, Christina Nalkurthi, Anna C. Schaar, Lorenzo Bonaguro, Tal Pecht, Izabela Galvao, Shobhit Agrawal, Adem Saglam, Erica Dudkin, Amit Frishberg, Elena de Domenico, Arik Horne, Chantal Donovan, Richard Y. Kim, David Gallego-Ortega, Tessa E. Gillett, Meshal Ansari, Jonas Schulte-Schrepping, Nina Offermann, Ignazio Antignano, Burcu Sivri, Wenying Lu, Mathew S. Eapen, Martina van Uelft, Collins Osei-Sarpong, Maarten van den Berge, Hylke C. Donker, Harry J.M. Groen, Sukhwinder S. Sohal, Johanna Klein, Tina Schreiber, Andreas Feißt, Ali Önder Yildirim, Herbert B. Schiller, Martijn C. Nawijn, Matthias Becker, Kristian Händler, Marc Beyer, Melania Capasso, Thomas Ulas, Jan Hasenauer, Carmen Pizarro, Fabian J. Theis, Philip M. Hansbro, Dirk Skowasch, Joachim L. Schultze
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112525- (2023)
Summary: Systemic inflammation is established as part of late-stage severe lung disease, but molecular, functional, and phenotypic changes in peripheral immune cells in early disease stages remain ill defined. Chronic obstructive pulmonary disease (C
Externí odkaz:
https://doaj.org/article/de07677bc6c241f3a6d5cd66f2c12fd0
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Precision cut lung slices (PCLS) have emerged as powerful experimental tools for respiratory research. Pioneering studies using mouse PCLS to visualize intrapulmonary airway contractility have been extended to pulmonary arteries and for assessment of
Externí odkaz:
https://doaj.org/article/af5f52d2455c4d8d9e7749ed6f6a6164
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Recent advances in mouse models of experimental asthma coupled with vast improvements in systems that assess respiratory physiology have considerably increased the accuracy and human relevance of the outputs from these studies. In fact, these models
Externí odkaz:
https://doaj.org/article/90ea8e3c33224ff3b33b6fd9530d9f36
Autor:
Andrew E. Thorpe, Chantal Donovan, Richard Y. Kim, Howard J. Vindin, Razia Zakarya, Hanna Miyai, Yik L. Chan, David van Reyk, Hui Chen, Brian G. Oliver
Publikováno v:
Toxics, Vol 11, Iss 9, p 749 (2023)
In the last decade, e-cigarette usage has increased, with an estimated 82 million e-cigarette users globally. This is, in part, due to the common opinion that they are “healthier” than tobacco cigarettes or simply “water vapour”. Third-hand e
Externí odkaz:
https://doaj.org/article/43cc2bfe71a9445eb5994607ee13f488
Publikováno v:
Nutrients, Vol 15, Iss 7, p 1783 (2023)
Background: The gut microbiome, which can be altered by different diets or smoking, has been implicated in the pathogenesis of lung conditions. E-cigarette vaping is now recognised to have detrimental health effects, with several of these being simil
Externí odkaz:
https://doaj.org/article/e412030857e440688e156da63b32160f