Cystine/glutamate antiporter xCT controls skeletal muscle glutathione redox, bioenergetics and differentiation

Autor: Michel N. Kanaan, Chantal A. Pileggi, Charbel Y. Karam, Luke S. Kennedy, Claire Fong-McMaster, Miroslava Cuperlovic-Culf, Mary-Ellen Harper

Publikováno v: Redox Biology, Vol 73, Iss , Pp 103213- (2024)

Cysteine, the rate-controlling amino acid in cellular glutathione synthesis is imported as cystine, by the cystine/glutamate antiporter, xCT, and subsequently reduced to cysteine. As glutathione redox is important in muscle regeneration in aging, we

Externí odkaz: https://doaj.org/article/d63665a9bcdb4a1697b39515309c5096

Grx2 Regulates Skeletal Muscle Mitochondrial Structure and Autophagy

Autor: Ava Liaghati, Chantal A. Pileggi, Gaganvir Parmar, David A. Patten, Nina Hadzimustafic, Alexanne Cuillerier, Keir J. Menzies, Yan Burelle, Mary-Ellen Harper

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

Glutathione is an important antioxidant that regulates cellular redox status and is disordered in many disease states. Glutaredoxin 2 (Grx2) is a glutathione-dependent oxidoreductase that plays a pivotal role in redox control by catalyzing reversible

Externí odkaz: https://doaj.org/article/b9ee757afd6042619bdf440302b6f161

Targeting skeletal muscle mitochondrial health in obesity

Autor: Chantal A. Pileggi, Breana G. Hooks, Ruth McPherson, Robert R.M. Dent, Mary-Ellen Harper

Publikováno v: Clinical Science. 136:1081-1110

Metabolic demands of skeletal muscle are substantial and are characterized normally as highly flexible and with a large dynamic range. Skeletal muscle composition (e.g., fiber type and mitochondrial content) and metabolism (e.g., capacity to switch b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb236d5fe2b4519b91c9dcdb69068bfe
https://doi.org/10.1042/cs20210506

SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver DiseaseSummary

Autor: Bernard L. Schneider, Rashmi Kothary, Maica Llavero-Hurtado, Thomas H. Gillingwater, Abdelmadjid Atrih, Alexandra Tierney, Jean Michaud, Ariane Beauvais, Thomas M. Wishart, Lucia Chehade, Marc-Olivier Deguise, Douglas J. Lamont, Simon H. Parson, Yves De Repentigny, Mary-Ellen Harper, Chantal A. Pileggi

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 354-377.e3 (2021)
Cellular and Molecular Gastroenterology and Hepatology
Deguise, M-O, Pileggi, C, De Repentigny, Y, Beauvais, A, Tierney, A, Chehade, L, Michaud, J, Llavero hurtado, M, Lamont, D, Atrih, A, Wishart, T, Gillingwater, T, Schneider, B L, Harper, M-E, Parson, S & Kothary, R 2021, ' SMN depleted mice offer a robust and rapid onset model of non-alcoholic fatty liver disease ', Cellular and Molecular Gastroenterology and Hepatology . https://doi.org/10.1016/j.jcmgh.2021.01.019

Background & Aims Nonalcoholic fatty liver disease (NAFLD) is considered a health epidemic with potential devastating effects on the patients and the healthcare systems. Current preclinical models of NAFLD are invariably imperfect and generally take

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7a717cf593f4034226b292cb0ee07cc
http://www.sciencedirect.com/science/article/pii/S2352345X21000254

Novel Homozygous Variant inCOQ7in Siblings With Hereditary Motor Neuropathy

Autor: Ian C. Smith, Chantal A. Pileggi, Ying Wang, Kristin Kernohan, Taila Hartley, Hugh J. McMillan, Marcos Loreto Sampaio, Gerd Melkus, John Woulfe, Gaganvir Parmar, Pierre R. Bourque, Ari Breiner, Jocelyn Zwicker, C. Elizabeth Pringle, Olga Jarinova, Hanns Lochmüller, David A. Dyment, Bernard Brais, Kym M. Boycott, Siegfried Hekimi, Mary-Ellen Harper, Jodi Warman-Chardon

Publikováno v: Neurology Genetics. 9:e200048

Background and ObjectivesCoenzyme Q10(CoQ10) is an important electron carrier and antioxidant. The COQ7 enzyme catalyzes the hydroxylation of 5-demethoxyubiquinone-10 (DMQ10), the second-to-last step in the CoQ10biosynthesis pathway. We report a cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f66ec566405f154749fac6421079a87
https://doi.org/10.1212/nxg.0000000000200048