Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor responses in melanoma patients at the cost of toxicity

Autor: Mandy W.M.M. van de Rakt, Kalijn F. Bol, Roel Mus, Gerty Schreibelt, Otto C. Boerman, I. Jolanda M. de Vries, Cornelis J. A. Punt, Michelle M. van Rossum, Wim J.G. Oyen, Sandra Croockewit, Jeanette M. Pots, Erik H.J.G. Aarntzen, Tom G. M. van Oorschot, Chantal A. A. van der Graaf, Michel A.M. Olde Nordkamp, Annemiek J. de Boer, Carl G. Figdor, Gosse J. Adema, Willeke A. M. Blokx, Nicole M. Scharenborg

Publikováno v: Cancer Immunology, Immunotherapy
Cancer Immunology Immunotherapy, 65, 327-39
Cancer Immunology Immunotherapy, 65, 3, pp. 327-39
Cancer immunology, immunotherapy, 65(3), 327-339. Springer Science and Business Media Deutschland GmbH

Dendritic cell (DC)-based immunotherapy is explored worldwide in cancer patients, predominantly with DC matured with pro-inflammatory cytokines and prostaglandin E2. We studied the safety and efficacy of vaccination with monocyte-derived DC matured w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ba2279ffaeb52be80bcb4f0a01ce39
https://hdl.handle.net/2066/171284

Differential Cytokine Production and Toll-Like Receptor Signaling Pathways by Candida albicans Blastoconidia and Hyphae

Autor: Bart Jan Kullberg, Ineke Verschueren, Chantal A. A. van der Graaf, Mihai G. Netea, Jos W. M. van der Meer

Publikováno v: Infection and Immunity, 73, 11, pp. 7458-64
Infection and Immunity, 73, 7458-64

Toll-like receptors (TLR) are crucial for an efficient antifungal defense. We investigated the differential recognition of blastoconidia and hyphae of Candida albicans by TLRs. In contrast to Candida blastoconidia, which stimulated large amounts of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e509320cac7123166960a26aceeec97d
https://doi.org/10.1128/iai.73.11.7458-7464.2005

The Role of Toll‐like Receptor (TLR) 2 and TLR4 in the Host Defense against Disseminated Candidiasis

Autor: Ineke Verschueren, Jos W. M. van der Meer, Chantal A. A. van der Graaf, Bart Jan Kullberg, Mihai G. Netea, Alieke G. Vonk

Publikováno v: The Journal of Infectious Diseases, 185, 10, pp. 1483-9
Journal of Infectious Diseases, 185, 1483-1489. Univ chicago press
Journal of Infectious Diseases, 185, 10, pp. 1483-1489
The Journal of Infectious Diseases, 185, 1483-9

Contains fulltext : 208279.pdf (Publisher’s version ) (Closed access) Toll-like receptors (TLRs) represent the main class of pattern-recognition receptors involved in sensing pathogenic microorganisms. The aim of the present study was to assess the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2caffcdaa097cecb2b509a2529d0e6
https://doi.org/10.1086/340511

STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis

Autor: Alexander Hoischen, Mihai G. Netea, Diana C. Rosentul, Bart Jan Kullberg, Desa Lilic, Frank L. van de Veerdonk, Christian Gilissen, Chantal A.A. Smits-van der Graaf, Theo S. Plantinga, Leo A. B. Joosten, Andrew J. Carmichael, Joris A. Veltman, Peer Arts, Sanne P. Smeekens, Jos W. M. van der Meer

Publikováno v: The New England Journal of Medicine, 365, 54-61
The New England Journal of Medicine, 365, 1, pp. 54-61

Contains fulltext : 98330.pdf (Publisher’s version ) (Closed access) BACKGROUND: Chronic mucocutaneous candidiasis (CMC) is characterized by susceptibility to candida infection of skin, nails, and mucous membranes. Patients with recessive CMC and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80354c168efc73330b16ab45011eec68
http://hdl.handle.net/2066/98330

Toll-like receptor 4 Asp299Gly/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infection

Autor: Chantal A A, Van der Graaf, Mihai G, Netea, Servaas A, Morré, Martin, Den Heijer, Paul E, Verweij, Jos W M, Van der Meer, Bart Jan, Kullberg

Publikováno v: European cytokine network. 17(1)

Toll-like receptor (TLR)-4 is an important pattern recognition receptor for Candida albicans, playing a role in innate host defense. We investigated whether there is an association between the TLR4 Asp299Gly or TLR4 Thr399Ile polymorphism, and the oc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db0e68a25de97e9b17b476e71fcf96a7
https://pubmed.ncbi.nlm.nih.gov/16613760