Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Chantal, Escrieut"'
Autor:
Marie-Julie Gherardi, Sadek Ismail, Daniel Fourmy, Minos-Timotheos Matsoukas, Arnau Cordomí, Leonardo Pardo, Chantal Escrieut
Publikováno v:
Biochemical Pharmacology. 96:237-246
Innovative crystallographic techniques have resulted in an exponential growth in the number of solved G-protein coupled receptor (GPCR) structures and a better understanding of the mechanisms of class A receptor activation and G protein binding. The
Autor:
Beatrice Waser, Pascal Clerc, Claire Sanchez, Jean Claude Reubi, Daniel Fourmy, Chantal Escrieut, Véronique Gigoux
Publikováno v:
Molecular and Cellular Endocrinology. 349:170-179
The cholecystokinin-2 receptor (CCK2R), is expressed in cancers where it contributes to tumor progression. The CCK2R is over-expressed in a sub-set of tumors, allowing its use in tumor targeting with a radiolabel ligand. Since discrepancies between m
Autor:
Danielle Gully, Nicole Vaysse, Jean Martinez, M. Bouisson, Véronique Gigouj, Bernard Maigret, Daniel Fourmy, Jean-Alain Fehrentz, Chantal Escrieut, Sandrine Silvente-Poirot, Luis Moroder
Publikováno v:
Protein Science
Protein Science, Wiley, 1999, 11, pp.2347-2354
Scopus-Elsevier
HAL
Protein Science, Wiley, 1999, 11, pp.2347-2354
Scopus-Elsevier
HAL
The knowledge of the binding sites of G protein-coupled cholecystokinin receptors represents important insights that may serve to understand their activation processes and to design or optimize ligands. Our aim was to identify the amino acid of the c
Autor:
Chantal Escrieut, Philippe Crespy, Eric Carnazzi, Daniel Fourmy, Jean Martinez, Catherine Oiry, Jean Claude Galleyrand, Géraldine Ibarz, Didier Gagne
Publikováno v:
British Journal of Pharmacology. 147:951-958
In cells overexpressing active MEKK1 to enhance c-Jun trans-activation, expression of rat cholecystokinin 1 receptor increased the activity of c-Jun while in the same experimental conditions overexpression of mouse cholecystokinin 1 receptor represse
Autor:
Mercedes Martín-Martínez, Anne Marty, Chantal Escrieut, M. Teresa García-López, Rosario Herranz, Rosario González-Muñiz, Daniel Fourmy, Bernard Maigret, Maud Jourdan, Elodie Archer
Publikováno v:
Journal of Medicinal Chemistry. 48:4842-4850
A rational combination of site-directed mutagenesis studies, structure-activity relationships, and dynamic-based docking of pyridopyrimidine-derived CCK1R antagonists into a refined three-dimensional model of the CCK1R allowed us to identify the rece
Autor:
Aline Kowalski-Chauvel, Audrey Ferrand, Chantal Escrieut, Anne Mathieu, Catherine Seva, Daniel Fourmy, Claudine Bertrand, Marlène Dufresne, Ghislaine Portolan, Lucien Pradayrol
Publikováno v:
Journal of Biological Chemistry. 280:10710-10715
To date very few G protein-coupled receptors (GPCRs) have been shown to be connected to the Janus kinase (JAK)/STAT pathway. Thus our understanding of the mechanisms involved in the activation of this signaling pathway by GPCRs remains limited. In ad
Autor:
Catherine Seva, Elodie Archer-Lahlou, Irina G. Tikhonova, Chantal Escrieut, Marlène Dufresne, Daniel Fourmy, Luis Moroder, Bernard Maigret, Lucien Pradayrol
Publikováno v:
Journal of Medicinal Chemistry. 48:180-191
The Cholecystokinin-1 receptor (CCK1R) mediates actions of CCK in areas of the central nervous system and of the gut. It is a potential target to treat a number of diseases. As for all G-protein-coupled receptors, docking of ligands into modeled CCK1
Autor:
Daniel Fourmy, Luis Moroder, Bernard Maigret, Jean-Alain Fehrentz, Jean Martinez, Véronique Gigoux, Céline Galés, Chantal Escrieut, Sandrine Silvente-Poirot, Elodie Archer, Lucien Pradayrol
Publikováno v:
Pharmacology & Toxicology. 91:313-320
Delineation of CCK receptor binding sites is a prerequisite for the understanding of the molecular basis for ligand recognition, partial agonism, ligand-induced traffiking of receptor signalling. In the current paper, we illustrate how, in the past 5
Autor:
Véronique Gigoux, Sophie Verrier, Bernard Maigret, Luis Moroder, Eric Bignon, Sandrine Silvente-Poirot, Elodie Archer, Lucien Pradayrol, Chantal Escrieut, Daniel Fourmy, Raymond Behrendt
Publikováno v:
Journal of Biological Chemistry. 277:7546-7555
The cholecystokinin (CCK) receptor-1 (CCK1R) is a G protein-coupled receptor, which mediates important central and peripheral cholecystokinin actions. Our aim was to progress in mapping of the CCK1R binding site by identifying residues that interact
Autor:
Laure di Malta, Jean Martinez, Nicole Bernad, Daniel Fourmy, Jean-Claude Galleyrand, Chantal Escrieut, Roya Poosti, Sandrine Silvente-Poirot, Didier Gagne
Publikováno v:
Scopus-Elsevier
It has previously been reported that the cholecystokinin analog JMV-180 behaves differently on the rat and the mouse cholecystokinin-A receptor (CCK-AR). In mice this analog acts as an agonist on low- and high-affinity sites of the CCK-AR, whereas in