Výsledky vyhledávání - "Chantal, Dessy"

Akademický článek

Diesel exhaust particles alter the profile and function of the gut microbiota upon subchronic oral administration in mice

Autor: Sybille van den Brule, Margaux Rappe, Jérôme Ambroise, Caroline Bouzin, Chantal Dessy, Adrien Paquot, Giulio G. Muccioli, Dominique Lison

Publikováno v: Particle and Fibre Toxicology, Vol 18, Iss 1, Pp 1-15 (2021)

Abstract Background Ambient air pollution by particulate matters, including diesel exhaust particles (DEP), is a major cause of cardiovascular and metabolic mortality worldwide. The mechanisms by which DEP cause these adverse outcomes are not complet

Externí odkaz: https://doaj.org/article/8f3dc1acf7f2480293d97c0ea4830df0

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Akademický článek

Sustained Downregulation of Vascular Smooth Muscle Acta2 After Transient Angiotensin II Infusion: A New Model of 'Vascular Memory'

Autor: Lucie Pothen, Roxane Verdoy, Delphine De Mulder, Hrag Esfahani, Charlotte Farah, Lauriane Y. M. Michel, Flavia Dei Zotti, Bertrand Bearzatto, Jerome Ambroise, Caroline Bouzin, Chantal Dessy, Jean-Luc Balligand

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 9 (2022)

BackgroundActivation of the renin-angiotensin-aldosterone system (RAAS) plays a critical role in the development of hypertension. Published evidence on a putative “memory effect” of AngII on the vascular components is however scarce.AimTo evaluat

Externí odkaz: https://doaj.org/article/0a5667dc34d44261a470827b67f43397

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Akademický článek

Beta 3 adrenoreceptors protect from hypertrophic remodelling through AMP‐activated protein kinase and autophagy

Autor: Emilie Dubois‐Deruy, Roselle Gelinas, Christophe Beauloye, Hrag Esfahani, Lauriane Y.M. Michel, Chantal Dessy, Luc Bertrand, Jean‐Luc Balligand

Publikováno v: ESC Heart Failure, Vol 7, Iss 3, Pp 920-932 (2020)

Abstract Aims The abundance of beta 3‐adrenergic receptors (β3‐ARs) is upregulated in diseased human myocardium. We previously showed that cardiac‐specific expression of β3‐AR inhibits the hypertrophic response to neurohormonal stimulation.

Externí odkaz: https://doaj.org/article/e857d977b4014689b2a3e9935f6fcd2f

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Akademický článek

TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells

Autor: Cyril Corbet, Estelle Bastien, Joao Pedro Santiago de Jesus, Emeline Dierge, Ruben Martherus, Catherine Vander Linden, Bastien Doix, Charline Degavre, Céline Guilbaud, Laurenne Petit, Carine Michiels, Chantal Dessy, Yvan Larondelle, Olivier Feron

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)

The tumour microenvironment is known to have an acidic pH but how this influences cancer cell phenotype is unclear. Here, the authors show that tumour cells upregulate TGF-β2 under acidosis, which leads to the increased formation of lipid droplets a

Externí odkaz: https://doaj.org/article/af7d4d7798c6436891d3d4c743591132

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Akademický článek

Targeting M2 Macrophages with a Novel NADPH Oxidase Inhibitor

Autor: Sébastien Dilly, Miguel Romero, Stéphanie Solier, Olivier Feron, Chantal Dessy, Anny Slama Schwok

Publikováno v: Antioxidants, Vol 12, Iss 2, p 440 (2023)

ROS in cancer cells play a key role in pathways regulating cell death, stemness maintenance, and metabolic reprogramming, all of which have been implicated in resistance to chemo/ immunotherapy. Adjusting ROS levels to reverse the resistance of cance

Externí odkaz: https://doaj.org/article/e1e3bcee90dc4b2fae475da457fb7efe

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Akademický článek

miR-199a Downregulation as a Driver of the NOX4/HIF-1α/VEGF-A Pathway in Thyroid and Orbital Adipose Tissues from Graves′ Patients

Autor: Julie Craps, Virginie Joris, Lelio Baldeschi, Chantal Daumerie, Alessandra Camboni, Antoine Buemi, Benoit Lengelé, Catherine Behets, Antonella Boschi, Michel Mourad, Marie-Christine Many, Chantal Dessy

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 1, p 153 (2021)

Graves’ disease (GD) is an autoimmune thyroiditis often associated with Graves’ orbitopathy (GO). GD thyroid and GO orbital fat share high oxidative stress (OS) and hypervascularization. We investigated the metabolic pathways leading to OS and an

Externí odkaz: https://doaj.org/article/f8ae572496a64513a02aba0a74a4c4e5

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