Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Chanson J Brumme"'
Autor:
Aniqa Shahid, Bradley R Jones, Julia S W Yang, Winnie Dong, Tawimas Shaipanich, Kathryn Donohoe, Chanson J Brumme, Jeffrey B Joy, Janice M Leung, Zabrina L Brumme
Publikováno v:
PLoS Pathogens, Vol 18, Iss 11, p e1010613 (2022)
The lung is an understudied site of HIV persistence. We isolated 898 subgenomic proviral sequences (nef) by single-genome approaches from blood and lung from nine individuals on long-term suppressive antiretroviral therapy (ART), and characterized ge
Externí odkaz:
https://doaj.org/article/b8375e0e10134f47b56087abcbfb4199
Publikováno v:
eLife, Vol 10 (2021)
Triple-drug therapies have transformed HIV from a fatal condition to a chronic one. These therapies should prevent HIV drug resistance evolution, because one or more drugs suppress any partially resistant viruses. In practice, such therapies drastica
Externí odkaz:
https://doaj.org/article/68ca2701fe2d4c6da909973361d1453d
Autor:
Tomohiro Akahoshi, Hiroyuki Gatanaga, Nozomi Kuse, Takayuki Chikata, Madoka Koyanagi, Naoki Ishizuka, Chanson J Brumme, Hayato Murakoshi, Zabrina L Brumme, Shinichi Oka, Masafumi Takiguchi
Publikováno v:
PLoS Pathogens, Vol 16, Iss 12, p e1009177 (2020)
HIV-1 strains harboring immune escape mutations can persist in circulation, but the impact of selection by multiple HLA alleles on population HIV-1 dynamics remains unclear. In Japan, HIV-1 Reverse Transcriptase codon 135 (RT135) is under strong immu
Externí odkaz:
https://doaj.org/article/cf317fa4c7d4460eb38d3f3929d01091
Autor:
Steven W Jin, Francis M Mwimanzi, Jaclyn K Mann, Mwebesa Bosco Bwana, Guinevere Q Lee, Chanson J Brumme, Peter W Hunt, Jeff N Martin, David R Bangsberg, Thumbi Ndung'u, Zabrina L Brumme, Mark A Brockman
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008813 (2020)
HIV Nef counteracts cellular host restriction factors SERINC3 and SERINC5, but our understanding of how naturally occurring global Nef sequence diversity impacts these activities is limited. Here, we quantify SERINC3 and SERINC5 internalization funct
Externí odkaz:
https://doaj.org/article/478d6961fecb493d9420cae6678958f6
Autor:
Genevieve Rocheleau, Conrado Franco-Villalobos, Natalia Oliveira, Zabrina L Brumme, Melanie Rusch, Jeannie Shoveller, Chanson J Brumme, P Richard Harrigan
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184848 (2017)
Sociodemographic correlates of engagement in human immunodeficiency virus (HIV) care are well studied, however the association with accessing drug resistance testing (DRT) and the development of drug resistance have not been characterized. Between 19
Externí odkaz:
https://doaj.org/article/bf1007ebedc5467e8e2cbe4a42750d0d
Autor:
Laura A Cotton, Xiaomei T Kuang, Anh Q Le, Jonathan M Carlson, Benjamin Chan, Denis R Chopera, Chanson J Brumme, Tristan J Markle, Eric Martin, Aniqa Shahid, Gursev Anmole, Philip Mwimanzi, Pauline Nassab, Kali A Penney, Manal A Rahman, M-J Milloy, Martin T Schechter, Martin Markowitz, Mary Carrington, Bruce D Walker, Theresa Wagner, Susan Buchbinder, Jonathan Fuchs, Beryl Koblin, Kenneth H Mayer, P Richard Harrigan, Mark A Brockman, Art F Y Poon, Zabrina L Brumme
Publikováno v:
PLoS Genetics, Vol 10, Iss 4, p e1004295 (2014)
HLA-restricted immune escape mutations that persist following HIV transmission could gradually spread through the viral population, thereby compromising host antiviral immunity as the epidemic progresses. To assess the extent and phenotypic impact of
Externí odkaz:
https://doaj.org/article/5120521a2c5e4e9facd0fbd9fe45093e
Autor:
Guinevere Q Lee, Winnie Dong, Theresa Mo, David J H F Knapp, Chanson J Brumme, Conan K Woods, Steve Kanters, Benita Yip, P Richard Harrigan
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99000 (2014)
BACKGROUND:HIV patients on suppressive antiretroviral therapy have undetectable viremia making it impossible to screen plasma HIV tropism if regimen change is required during suppression. We investigated the prevalence and predictors of tropism switc
Externí odkaz:
https://doaj.org/article/d100e8fd2e2b4f1486b03c03023ecbdc
Autor:
István Bartha, Jonathan M Carlson, Chanson J Brumme, Paul J McLaren, Zabrina L Brumme, Mina John, David W Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J O’Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M Allen, Viktor Müller, P Richard Harrigan, David Heckerman, Amalio Telenti, Jacques Fellay, for the HIV Genome-to-Genome Study and the Swiss HIV Cohort Study
Publikováno v:
eLife, Vol 2 (2013)
HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 seq
Externí odkaz:
https://doaj.org/article/5d773a28930442e492f392ab859e9ef9
Autor:
Matthew R Henn, Christian L Boutwell, Patrick Charlebois, Niall J Lennon, Karen A Power, Alexander R Macalalad, Aaron M Berlin, Christine M Malboeuf, Elizabeth M Ryan, Sante Gnerre, Michael C Zody, Rachel L Erlich, Lisa M Green, Andrew Berical, Yaoyu Wang, Monica Casali, Hendrik Streeck, Allyson K Bloom, Tim Dudek, Damien Tully, Ruchi Newman, Karen L Axten, Adrianne D Gladden, Laura Battis, Michael Kemper, Qiandong Zeng, Terrance P Shea, Sharvari Gujja, Carmen Zedlack, Olivier Gasser, Christian Brander, Christoph Hess, Huldrych F Günthard, Zabrina L Brumme, Chanson J Brumme, Suzane Bazner, Jenna Rychert, Jake P Tinsley, Ken H Mayer, Eric Rosenberg, Florencia Pereyra, Joshua Z Levin, Sarah K Young, Heiko Jessen, Marcus Altfeld, Bruce W Birren, Bruce D Walker, Todd M Allen
Publikováno v:
PLoS Pathogens, Vol 8, Iss 3, p e1002529 (2012)
Deep sequencing technologies have the potential to transform the study of highly variable viral pathogens by providing a rapid and cost-effective approach to sensitively characterize rapidly evolving viral quasispecies. Here, we report on a high-thro
Externí odkaz:
https://doaj.org/article/7846f6a69b894bfaae962b545cdfe22c
Autor:
Jonathan Z Li, Chanson J Brumme, Michael M Lederman, Zabrina L Brumme, Hongying Wang, John Spritzler, Mary Carrington, Kathleen Medvik, Bruce D Walker, Robert T Schooley, Daniel R Kuritzkes, AIDS Clinical Trials Group A5197 Study Team
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34134 (2012)
In the placebo-controlled trial ACTG A5197, a trend favoring viral suppression was seen in the HIV-1-infected subjects who received a recombinant Ad5 HIV-1 gag vaccine.To identify individuals with initial viral suppression (plasma HIV-1 RNA set point
Externí odkaz:
https://doaj.org/article/0d65036480d84ec5a93c252017b99c2a