Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Chanpheng Phommaly"'
Autor:
Jonathan T. Lei, Jieya Shao, Jin Zhang, Michael Iglesia, Doug W. Chan, Jin Cao, Meenakshi Anurag, Purba Singh, Xiaping He, Yoshimasa Kosaka, Ryoichi Matsunuma, Robert Crowder, Jeremy Hoog, Chanpheng Phommaly, Rodrigo Goncalves, Susana Ramalho, Raquel Mary Rodrigues Peres, Nindo Punturi, Cheryl Schmidt, Alex Bartram, Eric Jou, Vaishnavi Devarakonda, Kimberly R. Holloway, W. Victoria Lai, Oliver Hampton, Anna Rogers, Ethan Tobias, Poojan A. Parikh, Sherri R. Davies, Shunqiang Li, Cynthia X. Ma, Vera J. Suman, Kelly K. Hunt, Mark A. Watson, Katherine A. Hoadley, E. Aubrey Thompson, Xi Chen, Shyam M. Kavuri, Chad J. Creighton, Christopher A. Maher, Charles M. Perou, Svasti Haricharan, Matthew J. Ellis
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1434-1444.e7 (2018)
Summary: RNA sequencing (RNA-seq) detects estrogen receptor alpha gene (ESR1) fusion transcripts in estrogen receptor-positive (ER+) breast cancer, but their role in disease pathogenesis remains unclear. We examined multiple ESR1 fusions and found th
Externí odkaz:
https://doaj.org/article/b6b75cb5a81b49bf90d37ac3366f6ea7
Autor:
Shunqiang Li, Dong Shen, Jieya Shao, Robert Crowder, Wenbin Liu, Aleix Prat, Xiaping He, Shuying Liu, Jeremy Hoog, Charles Lu, Li Ding, Obi L. Griffith, Christopher Miller, Dave Larson, Robert S. Fulton, Michelle Harrison, Tom Mooney, Joshua F. McMichael, Jingqin Luo, Yu Tao, Rodrigo Goncalves, Christopher Schlosberg, Jeffrey F. Hiken, Laila Saied, Cesar Sanchez, Therese Giuntoli, Caroline Bumb, Crystal Cooper, Robert T. Kitchens, Austin Lin, Chanpheng Phommaly, Sherri R. Davies, Jin Zhang, Megha Shyam Kavuri, Donna McEachern, Yi Yu Dong, Cynthia Ma, Timothy Pluard, Michael Naughton, Ron Bose, Rama Suresh, Reida McDowell, Loren Michel, Rebecca Aft, William Gillanders, Katherine DeSchryver, Richard K. Wilson, Shaomeng Wang, Gordon B. Mills, Ana Gonzalez-Angulo, John R. Edwards, Christopher Maher, Charles M. Perou, Elaine R. Mardis, Matthew J. Ellis
Publikováno v:
Cell Reports, Vol 4, Iss 6, Pp 1116-1130 (2013)
To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating breast cancers representative of the major intrinsic subtypes. Structural and copy number aberrations were found to be retaine
Externí odkaz:
https://doaj.org/article/1caf49e311cd490a9bd70c469f4ea5ca
Autor:
Matthew J. Ellis, Jason D. Weber, Anthony Saporita, Mark A. Watson, John A. Olson, Sherri R. Davies, Jacqueline Snider, Li Lin, David G. Huntsman, Melinda A. Miller, Joel S. Parker, Charles M. Perou, Jingqin Luo, Jeremy Hoog, Yu Tao, Chanpheng Phommaly, Robert J. Crowder
Supplementary Table 1 from PIK3CA and PIK3CB Inhibition Produce Synthetic Lethality when Combined with Estrogen Deprivation in Estrogen Receptor–Positive Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7949fb42a058e1882e716fbff39c3456
https://doi.org/10.1158/0008-5472.22380296.v1
https://doi.org/10.1158/0008-5472.22380296.v1
Autor:
Matthew J. Ellis, Jason D. Weber, Anthony Saporita, Mark A. Watson, John A. Olson, Sherri R. Davies, Jacqueline Snider, Li Lin, David G. Huntsman, Melinda A. Miller, Joel S. Parker, Charles M. Perou, Jingqin Luo, Jeremy Hoog, Yu Tao, Chanpheng Phommaly, Robert J. Crowder
Supplementary Methods and Materials from PIK3CA and PIK3CB Inhibition Produce Synthetic Lethality when Combined with Estrogen Deprivation in Estrogen Receptor–Positive Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf6759599c88c28239161441ba5dfc0
https://doi.org/10.1158/0008-5472.22380299.v1
https://doi.org/10.1158/0008-5472.22380299.v1
Autor:
Matthew J. Ellis, Jason D. Weber, Anthony Saporita, Mark A. Watson, John A. Olson, Sherri R. Davies, Jacqueline Snider, Li Lin, David G. Huntsman, Melinda A. Miller, Joel S. Parker, Charles M. Perou, Jingqin Luo, Jeremy Hoog, Yu Tao, Chanpheng Phommaly, Robert J. Crowder
Several phosphoinositide 3-kinase (PI3K) catalytic subunit inhibitors are currently in clinical trial. We therefore sought to examine relationships between pharmacologic inhibition and somatic mutations in PI3K catalytic subunits in estrogen receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10595c3101460391f65e7b43d27b95a6
https://doi.org/10.1158/0008-5472.c.6499523.v1
https://doi.org/10.1158/0008-5472.c.6499523.v1
Autor:
Rodrigo Franco Gonçalves, Xian Chen, Christopher A. Maher, Sherri R. Davies, Katherine A. Hoadley, Jeremy Hoog, Anna Rogers, MJ Ellis, Jing Zhang, Chad J. Creighton, Jonathan T. Lei, Robert J. Crowder, W-C Lai, Oliver A. Hampton, Y Kosaka, K. K. Hunt, DW Chan, Vera J. Suman, CM Perou, Cheryl Schmidt, Mark F. Watson, Ryoichi Matsunuma, Michael D. Iglesia, A. Thompson, Ethan Tobias, Svasti Haricharan, Xiaoping He, Jieya Shao, P Parikh, J Cao, Cynthia X. Ma, Susana Ramalho, Chanpheng Phommaly
Publikováno v:
Cancer Research. 77:PD2-03
Background. We previously reported an alternative ESR1 somatic gain-of-function chromosomal translocation event in a patient presenting with aggressive, endocrine therapy resistant estrogen receptor (ER) positive disease, producing an in-frame fusion
Publikováno v:
Cancer Research. 70:P2-19
Background: We have recently shown that acquired resistance to aromatase inhibitors (AI) can, in some instances, be reversed low-dose estradiol treatment until progression followed by repeat treatment with an aromatase inhibitor (Ellis, M. JAMA 302:7
Autor:
Vera J. Suman, Katherine A. Hoadley, Xi Chen, Christopher G. Maher, Xiaping He, Shunqiang Li, Doug W. Chan, Yoshimasa Kosaka, Jeremy Hoog, Matthew J. Ellis, Raquel Mary Rodrigues Peres, Purba Singh, Nindo Punturi, Chad J. Creighton, Alex Bartram, Vaishnavi Devarakonda, Robert J. Crowder, Svasti Haricharan, Jonathan T. Lei, Shyam M. Kavuri, Mark A. Watson, Jin Zhang, Rodrigo Franco Gonçalves, Michael D. Iglesia, Jin Cao, Chanpheng Phommaly, E. Aubrey Thompson, Jieya Shao, Cheryl Schmidt, P Parikh, Cynthia X. Ma, Susana Ramalho, Ryoichi Matsunuma, Kimberly R. Holloway, Eric Jou, Kelly K. Hunt, Meenakshi Anurag, W. Victoria Lai, Sherri R. Davies, Ethan Tobias, Anna Rogers, Charles M. Perou, Oliver A. Hampton
Publikováno v:
Cell Reports, Vol 24, Iss 6, Pp 1434-1444.e7 (2018)
Cell reports
Cell reports
SUMMARY RNA sequencing (RNA-seq) detects estrogen receptor alpha gene (ESR1) fusion transcripts in estrogen receptor-positive (ER+) breast cancer, but their role in disease pathogenesis remains unclear. We examined multiple ESR1 fusions and found tha
Autor:
Mark F. Watson, Ethan Tobias, MJ Ellis, Sherri R. Davies, K. K. Hunt, Shyam M. Kavuri, Rodrigo Franco Gonçalves, Anna Rogers, Katherine A. Hoadley, A. Thompson, Jin Cao, Oliver A. Hampton, Jonathan T. Lei, Ryoichi Matsunuma, Jing Zhang, Meenakshi Anurag, DW Chan, Vera J. Suman, Robert J. Crowder, Svasti Haricharan, Christopher A. Maher, Chad J. Creighton, Cheryl Schmidt, W-C Lai, Yoshimasa Kosaka, Jeremy Hoog, Michael D. Iglesia, Puneet Singh, Jieya Shao, Chanpheng Phommaly, Raquel Mary Rodrigues-Peres, P Parikh, Cynthia X. Ma, Susana Ramalho, CM Perou
Publikováno v:
Cancer Research. 78:PD8-03
Background. Dysregulation of the estrogen receptor gene (ESR1) is an established mechanism of inducing endocrine therapy resistance. We previously discovered a chromosomal translocation event generating an estrogen receptor gene fused in-frame to C-t
Autor:
Obi L. Griffith, Christopher A. Maher, MJ Ellis, Jieya Shao, Shuhong Li, Elaine R. Mardis, CM Perou, Rodrigo Franco Gonçalves, SN Johnson, Robert J. Crowder, R.T. Kitchens, Chanpheng Phommaly
Publikováno v:
Cancer Research. 73:S3-05
Endocrine therapy resistance occurs in 50% of estrogen receptor positive (ER+) luminal breast cancers but the underlying mechanisms are poorly understood. To gain insight, we have taken advantage of whole-genome and RNA sequencing data of five late-s