Zobrazeno 1 - 10
of 545
pro vyhledávání: '"Channing J Der"'
Autor:
Katherine H Pedone, Vanessa González-Pérez, Luciana E Leopold, Neal R Rasmussen, Channing J Der, Adrienne D Cox, Shawn Ahmed, David J Reiner
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 9 (2021)
AbstractUsing model organisms to identify novel therapeutic targets is frequently constrained by pre-existing genetic toolkits. To expedite positive selection for identification of novel downstream effectors, we engineered conditional expression of a
Externí odkaz:
https://doaj.org/article/c7c88b8ef42d4728ba9e8e9a3815be33
Autor:
Jeran K Stratford, Feng Yan, Rebecca A Hill, Michael B Major, Lee M Graves, Channing J Der, Jen Jen Yeh
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174863 (2017)
Pancreatic ductal adenocarcinoma, which accounts for the majority of pancreatic cancers, is a lethal disease with few therapeutic options. Genomic profiling of pancreatic ductal adenocarcinoma has identified a complex and heterogeneous landscape. Und
Externí odkaz:
https://doaj.org/article/a4307da2b3164585b704755c21db35c6
Autor:
Daniel P. Nussbaum, Colin A. Martz, Andrew M. Waters, Alejandro Barrera, Annie Liu, Justine C. Rutter, Christian G. Cerda-Smith, Amy E. Stewart, Chao Wu, Merve Cakir, Cecilia B. Levandowski, David E. Kantrowitz, Shannon J. McCall, Mariaelena Pierobon, Emanuel F. Petricoin, J. Joshua Smith, Timothy E. Reddy, Channing J. Der, Dylan J. Taatjes, Kris C. Wood
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Acquired resistance remains a major challenge for therapies targeting oncogene activated pathways. KRAS is the most frequently mutated oncogene in human cancers, yet strategies targeting its downstream signaling kinases have failed to produc
Externí odkaz:
https://doaj.org/article/f640317b562445dfa0b4f3772b68e0d1
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133226 (2015)
Wnt signaling controls various aspects of developmental and cell biology, as well as contributing to certain cancers. Expression of the human Rho family small GTPase Wrch/RhoU is regulated by Wnt signaling, and Wrch and its paralog Chp/RhoV are both
Externí odkaz:
https://doaj.org/article/f78bcdb3b8e041cf958924d02b160b9c
Autor:
Natalia Mitin, Kent L Rossman, Rachel Currin, Sandeep Anne, Thomas W Marshall, James E Bear, Victoria L Bautch, Channing J Der
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66260 (2013)
Persistent cellular migration requires efficient protrusion of the front of the cell, the leading edge where the actin cytoskeleton and cell-substrate adhesions undergo constant rearrangement. Rho family GTPases are essential regulators of the actin
Externí odkaz:
https://doaj.org/article/1e081d6027f240b2bbd5f880db7358be
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41876 (2012)
Spatio-temporal activation of Rho GTPases is essential for their function in a variety of biological processes and is achieved in part by regulating the localization of their activators, the Rho guanine nucleotide exchange factors (RhoGEFs). In this
Externí odkaz:
https://doaj.org/article/dd7285618bde4ee6b6c803fde0e57d29
Autor:
Jeran K Stratford, David J Bentrem, Judy M Anderson, Cheng Fan, Keith A Volmar, J S Marron, Elizabeth D Routh, Laura S Caskey, Jonathan C Samuel, Channing J Der, Leigh B Thorne, Benjamin F Calvo, Hong Jin Kim, Mark S Talamonti, Christine A Iacobuzio-Donahue, Michael A Hollingsworth, Charles M Perou, Jen Jen Yeh
Publikováno v:
PLoS Medicine, Vol 7, Iss 7, p e1000307 (2010)
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease. For patients with localized PDAC, surgery is the best option, but with a median survival of less than 2 years and a difficult and prolonged postoperative course for most, there is an u
Externí odkaz:
https://doaj.org/article/8637234746224f3e9ffbe1636aaf9a1d
Autor:
Francis S Willard, Melinda D Willard, Adam J Kimple, Meera Soundararajan, Emily A Oestreich, Xiaoyan Li, Nathaniel A Sowa, Randall J Kimple, Declan A Doyle, Channing J Der, Mark J Zylka, William D Snider, David P Siderovski
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4884 (2009)
Regulator of G-protein signaling (RGS) proteins have been well-described as accelerators of Galpha-mediated GTP hydrolysis ("GTPase-accelerating proteins" or GAPs). However, RGS proteins with complex domain architectures are now known to regulate muc
Externí odkaz:
https://doaj.org/article/e73be97520f24b928d7268fff21c829a
Autor:
Bartosz Mucha, Shuo Qie, Sagar Bajpai, Vincenzo Tarallo, J. Nathaniel Diehl, Frank Tedeschi, Gao Zhou, Zhaofeng Gao, Samuel Flashner, Andres J. Klein-Szanto, Hanina Hibshoosh, Shimonosono Masataka, Olga S. Chajewski, Ireneusz Majsterek, Dariusz Pytel, Maria Hatzoglou, Channing J. Der, Hiroshi Nakagawa, Adam J. Bass, Kwok-Kin Wong, Serge Y. Fuchs, Anil K. Rustgi, Eckhard Jankowsky, J. Alan Diehl
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Cytoplasmic accumulation of RNA binding protein, hnRNPK in cancer cells is associated with poor prognosis. Here the authors show that SCFFbxo4 E3 ubiquitin ligase-mediated polyubiquitylation of hnRNPK restricts c-Myc translation and limits cancer pro
Externí odkaz:
https://doaj.org/article/fecd2f81e26b43a3b3aad7932728969f
Autor:
Anna Barkovskaya, Craig M. Goodwin, Kotryna Seip, Bylgja Hilmarsdottir, Solveig Pettersen, Clint Stalnecker, Olav Engebraaten, Eirikur Briem, Channing J. Der, Siver A. Moestue, Thorarinn Gudjonsson, Gunhild M. Mælandsmo, Lina Prasmickaite
Publikováno v:
Molecular Oncology, Vol 15, Iss 8, Pp 2026-2045 (2021)
Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple‐negative breast cancer (TNBC). Here, we use
Externí odkaz:
https://doaj.org/article/0cf47b80942b4dccb4f54632467c29f1