Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Channel trafficking"'
Autor:
Xinle Zou, Sri Karthika Shanmugam, Scott A Kanner, Kevin J Sampson, Robert S Kass, Henry M Colecraft
Publikováno v:
eLife, Vol 12 (2023)
The slow delayed rectifier potassium current, IKs, conducted through pore-forming Q1 and auxiliary E1 ion channel complexes is important for human cardiac action potential repolarization. During exercise or fright, IKs is up-regulated by protein kina
Externí odkaz:
https://doaj.org/article/2149105d957e415abf19bc5da42ba7a7
Autor:
Sidharth Tyagi, Nivedita Sarveswaran, Grant P. Higerd-Rusli, Shujun Liu, Fadia B. Dib-Hajj, Stephen G. Waxman, Sulayman D. Dib-Hajj
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Non-addictive treatment of chronic pain represents a major unmet clinical need. Peripheral voltage-gated sodium (NaV) channels are an attractive target for pain therapy because they initiate and propagate action potentials in primary afferents that d
Externí odkaz:
https://doaj.org/article/a0ecf55f00dd4bc59cf9e51a8896351e
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Vascular smooth muscle contraction is intimately tied to membrane potential and the rise in intracellular Ca2+ enabled by the opening of L-type Ca2+ channels. While voltage is often viewed as the single critical factor gating these channels, research
Externí odkaz:
https://doaj.org/article/64b9a0c6fb39456faa74f8508f67dff0
Autor:
Haoyang Lu, Wen Ding, Hui Xiao, Manyu Dai, Yangcheng Xue, Zhuoran Jia, Jie Guo, Mengzuo Wu, Bing Shen, Ren Zhao
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Dysfunction of potassium voltage-gated channel subfamily Q member 1 (KCNQ1) is a primary cause of long QT syndrome type 1 (LQT1). Here, we report a missense mutation P441L in KCNQ1 C-terminus of a 37-year-old woman with severe LQT1 phenotype. Variant
Externí odkaz:
https://doaj.org/article/822d77695b2241489d1aba6d419a3bb7
Akademický článek
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Autor:
Daniele Ferrante, Bruno Sterlini, Cosimo Prestigio, Antonella Marte, Anna Corradi, Franco Onofri, Giorgio Tortarolo, Giuseppe Vicidomini, Andrea Petretto, Jessica Muià, Agnes Thalhammer, Pierluigi Valente, Lorenzo A. Cingolani, Fabio Benfenati, Pietro Baldelli
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109248- (2021)
Summary: Loss-of-function mutations in proline-rich transmembrane protein-2 (PRRT2) cause paroxysmal disorders associated with defective Ca2+ dependence of glutamatergic transmission. We find that either acute or constitutive PRRT2 deletion induces a
Externí odkaz:
https://doaj.org/article/6a130e3a58d54960b3694a3944741bd1
Publikováno v:
Physiological Reports, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract During development, maturation, or aging, the expression and function of urinary bladder smooth muscle (UBSM) ion channels can change, thus affecting micturition. Increasing evidence supports a novel role of transient receptor potential mela
Externí odkaz:
https://doaj.org/article/af37feac4b4544f29af834fdc22a2ecd
Autor:
Vittoria Di Mauro, Paola Ceriotti, Francesco Lodola, Nicolò Salvarani, Jessica Modica, Marie-Louise Bang, Andrea Mazzanti, Carlo Napolitano, Silvia G. Priori, Daniele Catalucci
Publikováno v:
Frontiers in Physiology, Vol 11 (2021)
Brugada syndrome (BrS) is an inherited arrhythmogenic disease that may lead to sudden cardiac death in young adults with structurally normal hearts. No pharmacological therapy is available for BrS patients. This situation highlights the urgent need t
Externí odkaz:
https://doaj.org/article/185089ae836f4f82a40fa10a9c2cfed3
Autor:
Voelker, Taylor L, Del Villar, Silvia G, Westhoff, Maartje, Costa, Alexandre D, Coleman, Andrea M, Hell, Johannes W, Horne, Mary C, Dickson, Eamonn J, Dixon, Rose E
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 14
CaV1.2 channels are critical players in cardiac excitation-contraction coupling, yet we do not understand how they are affected by an important therapeutic target of heart failure drugs and regulator of blood pressure, angiotensin II. Signaling throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::23325339dd525c7cad9b280fe4caed32
https://escholarship.org/uc/item/9cz4g77z
https://escholarship.org/uc/item/9cz4g77z
Publikováno v:
The Journal of Physiology. Wiley-Blackwell
Cardiac electrophysiology is regulated by continuous trafficking and internalization of ion channels occurring over minutes to hours. Kv11.1 (also known as hERG) underlies the rapidly activating delayed-rectifier K⁺ current (IKr), which plays a maj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663ef15ec40942752189e74c806583d3
https://cris.maastrichtuniversity.nl/en/publications/c5e3a609-e3bb-4b92-9736-51a464bc6f65
https://cris.maastrichtuniversity.nl/en/publications/c5e3a609-e3bb-4b92-9736-51a464bc6f65