Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Channa Bao"'
Autor:
Gregory M Dillon, Jaclyn L Henderson, Channa Bao, John A Joyce, Michael Calhoun, Brenda Amaral, Kristopher W King, Bekim Bajrami, Dania Rabah
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0228771 (2020)
Hyperphosphorylated tau protein is a pathological hallmark of numerous neurodegenerative diseases and the level of tau pathology is correlated with the degree of cognitive impairment. Tau hyper-phosphorylation is thought to be an early initiating eve
Externí odkaz:
https://doaj.org/article/4ad3843a90eb46f59942329ffdb2df81
Autor:
Jayanth V. Chodaparambil, Benbo Gao, Gregory M Dillon, Hannah M. Kerns, Jaclyn L. Henderson, Douglas Marcotte, Ru Wei, Bekim Bajrami, Channa Bao
Publikováno v:
Cellular and Molecular Neurobiology. 41:669-685
Tau-tubulin kinase 1 (TTBK1) is a CNS-specific, kinase that has been implicated in the pathological phosphorylation of tau in Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD). TTBK1 is a challenging therapeutic target because it shares a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::785ba6754ca160aed7d4ffda2a0c284a
https://doi.org/10.1007/s10571-020-00875-6
https://doi.org/10.1007/s10571-020-00875-6
Autor:
Elizabeth R. Spencer, Wen Shi, Robert W. Komorowski, James P. Gilbert, Lauren M. Ostrowski, Lynne M. Bird, Ronald Thibert, Channa Bao, Fiona Molloy, Michael Calhoun, Samir Koirala, Paymaan Jafar-nejad, Frank Rigo, Mark A. Kramer, Catherine J. Chu
Publikováno v:
Brain communications. 4(3)
Angelman syndrome is a neurodevelopmental disorder caused by deficiency of the maternally inherited UBE3A gene in neurons. Antisense oligonucleotide therapies are under development to reinstate UBE3A protein production. Non-invasive biomarkers to det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acd10008f199323cade054f3894772ff
https://pubmed.ncbi.nlm.nih.gov/35611307
https://pubmed.ncbi.nlm.nih.gov/35611307
Autor:
Kristopher W King, Brenda Amaral, Eli Schuman, LaiYee Wong, Michael Rooney, Marta Nevalainen, Jun Feng, Paramasivam Murugan, Jayanth V. Chodaparambil, Thomas A. Patterson, Hannah Certo, Martin K Himmelbauer, Rab Gilfillan, Tamara Halkina, Sarah Lamore, J Howard Jones, Douglas Marcotte, Gregory M Dillon, Jaclyn L. Henderson, Thomas Hesson, P Rajesh Kumar, Edward Yin-Shiang Lin, Channa Bao, Felix Gonzalez-Lopez de Turiso, Joshua L Johnson, Michael Calhoun
Publikováno v:
Journal of medicinal chemistry. 64(9)
Structural analysis of the known NIK inhibitor 3 bound to the kinase domain of TTBK1 led to the design and synthesis of a novel class of azaindazole TTBK1 inhibitors exemplified by 8 (cell IC50: 571 nM). Systematic optimization of this series of anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24de7147f81434a735de9781d30290ec
https://pubmed.ncbi.nlm.nih.gov/33944571
https://pubmed.ncbi.nlm.nih.gov/33944571
Autor:
Channa, Bao, Bekim, Bajrami, Douglas J, Marcotte, Jayanth V, Chodaparambil, Hannah M, Kerns, Jaclyn, Henderson, Ru, Wei, Benbo, Gao, Gregory M, Dillon
Publikováno v:
Cellular and molecular neurobiology. 41(4)
Tau-tubulin kinase 1 (TTBK1) is a CNS-specific, kinase that has been implicated in the pathological phosphorylation of tau in Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD). TTBK1 is a challenging therapeutic target because it shares a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6c6ff604205513513cb5b117098fe34
https://pubmed.ncbi.nlm.nih.gov/32424773
https://pubmed.ncbi.nlm.nih.gov/32424773
Autor:
Dania Rabah, Channa Bao, Gregory M Dillon, Jaclyn L. Henderson, Bekim Bajrami, Michael Calhoun, Kristopher W King, Brenda Amaral, John A. Joyce
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0228771 (2020)
PLoS ONE
PLoS ONE
Hyperphosphorylated tau protein is a pathological hallmark of numerous neurodegenerative diseases and the level of tau pathology is correlated with the degree of cognitive impairment. Tau hyper-phosphorylation is thought to be an early initiating eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b8432c06edf6c167c2d9a26d65d8068
https://doaj.org/article/4ad3843a90eb46f59942329ffdb2df81
https://doaj.org/article/4ad3843a90eb46f59942329ffdb2df81
Autor:
Jonathan A. Fidler, Kuma Misra, Christopher M. Treleaven, Richard L. Sidman, Thomas J. Tamsett, Seng H. Cheng, James Dodge, Tatyana V. Taksir, Channa Bao, Lamya S. Shihabuddin, Michelle Searles
Publikováno v:
Proceedings of the National Academy of Sciences. 110:10812-10817
Metabolic dysfunction is an important modulator of disease course in amyotrophic lateral sclerosis (ALS). We report here that a familial mouse model (transgenic mice over-expressing the G93A mutation of the Cu/Zn superoxide dismutase 1 gene) of ALS e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe609911cb4c5deaa2ca2b50df1d521
https://doi.org/10.1073/pnas.1308421110
https://doi.org/10.1073/pnas.1308421110
Autor:
Christopher M. Treleaven, James Dodge, S. Pablo Sardi, Lamya S. Shihabuddin, Seng H. Cheng, Joshua Pacheco, Wei-Lien Chuang, Channa Bao, Richard L. Sidman, Samantha Cooper, Marissa Abraham, Mandy Cromwell
Recent genetic evidence suggests that aberrant glycosphingolipid metabolism plays an important role in several neuromuscular diseases including hereditary spastic paraplegia, hereditary sensory neuropathy type 1, and non-5q spinal muscular atrophy. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c464ef2f5054108bce69eea643407dc5
https://europepmc.org/articles/PMC4491749/
https://europepmc.org/articles/PMC4491749/
Autor:
Selda, Samakoglu, Dhanvanthri S, Deevi, Huiling, Li, Su, Wang, Mary, Murphy, Channa, Bao, Rajiv, Bassi, Marie, Prewett, James R, Tonra
Publikováno v:
Cancer genomicsproteomics. 9(2)
Although the addition of epidermal growth factor receptor (EGFR) antibodies to various platinum-based chemotherapy regimens for non-small cell lung cancer (NSCLC) is being actively pursued in the clinic, rationale for the prioritization of specific r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bc98fe2256d141f28b76d08fa7fa8eeb
https://pubmed.ncbi.nlm.nih.gov/22399498
https://pubmed.ncbi.nlm.nih.gov/22399498
Publikováno v:
Cancer Research. 71:5030-5030
Epidermal growth factor receptor (EGFR) targeted antibodies may have a role in the treatment of non-small cell lung cancer (NSCLC), based on preclinical and clinical data. Here we have demonstrated a significant benefit of adding necitumumab, a recom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5105dedd2096b76e8b5c1a18395f1c68
https://doi.org/10.1158/1538-7445.am2011-5030
https://doi.org/10.1158/1538-7445.am2011-5030