Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Chanil Valasarajan"'
Autor:
Matthias S. Leisegang, Jasleen Kaur Bains, Sandra Seredinski, James A. Oo, Nina M. Krause, Chao-Chung Kuo, Stefan Günther, Nevcin Sentürk Cetin, Timothy Warwick, Can Cao, Frederike Boos, Judit Izquierdo Ponce, Shaza Haydar, Rebecca Bednarz, Chanil Valasarajan, Dominik C. Fuhrmann, Jens Preussner, Mario Looso, Soni S. Pullamsetti, Marcel H. Schulz, Hendrik R. A. Jonker, Christian Richter, Flávia Rezende, Ralf Gilsbach, Beatrice Pflüger-Müller, Ilka Wittig, Ingrid Grummt, Teodora Ribarska, Ivan G. Costa, Harald Schwalbe, Ralf P. Brandes
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Using a composite bioinformatics approach, the DNA:DNA:RNA triplex-forming lncRNAs HIF1α-AS1 was identified in human endothelial cells which recruits an epigenetic silencing complex to limit expression of triplex target genes.
Externí odkaz:
https://doaj.org/article/c3f7ecd225714cd98fa4bafc76a4baa2
Autor:
Andreas Weigert, Xiang Zheng, Alina Nenzel, Kati Turkowski, Stefan Günther, Elisabeth Strack, Evelyn Sirait-Fischer, Eiman Elwakeel, Ivan M. Kur, Vandana S. Nikam, Chanil Valasarajan, Hauke Winter, Alexander Wissgott, Robert Voswinkel, Friedrich Grimminger, Bernhard Brüne, Werner Seeger, Soni Savai Pullamsetti, Rajkumar Savai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Fibrocytes are monocyte-derived cells implicated in wound healing. Here, the authors utilise single cell RNA-seq, genetic ablation and multiplexed imaging to identify a fibrocyte population in lung cancer models, and use human lung cancer coculture s
Externí odkaz:
https://doaj.org/article/a45ef476278744d49bbf2334b639d6fb
Autor:
Swati Dabral, Christian Muecke, Chanil Valasarajan, Mario Schmoranzer, Astrid Wietelmann, Gregg L. Semenza, Michael Meister, Thomas Muley, Tamina Seeger-Nukpezah, Christos Samakovlis, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Rajkumar Savai, Soni S. Pullamsetti
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Pulmonary hypertension is characterized by a metabolic switch similar to the Warburg effect in cancer. Here Dabral et al. describe a RASSF1a-HIF-1α feedforward loop driving the Warburg effect both in a mouse model of hypoxia-induced pulmonary hypert
Externí odkaz:
https://doaj.org/article/a8901cfbf7474186b10f84b921b3e98d
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 66:473-475
Autor:
Prakash Chelladurai, Carsten Kuenne, Alice Bourgeois, Stefan Günther, Chanil Valasarajan, Anoop V. Cherian, Robbert J. Rottier, Charlotte Romanet, Andreas Weigert, Olivier Boucherat, Christina A. Eichstaedt, Clemens Ruppert, Andreas Guenther, Thomas Braun, Mario Looso, Rajkumar Savai, Werner Seeger, Uta-Maria Bauer, Sébastien Bonnet, Soni Savai Pullamsetti
Publikováno v:
Science Translational Medicine, 14(648):eabe5407. American Association for the Advancement of Science
Phenotypic alterations in resident vascular cells contribute to the vascular remodeling process in diseases such as pulmonary (arterial) hypertension [P(A)H]. How the molecular interplay between transcriptional coactivators, transcription factors (TF
Autor:
Marcel H. Schulz, Dominik C. Fuhrmann, C. Cao, R. Bednarz, Chanil Valasarajan, James A. Oo, J. Izquierdo Ponce, F. Boos, Ralf P. Brandes, Ivan G. Costa, Ralf Gilsbach, Harald Schwalbe, Timothy Warwick, N. M. Krause, S. S. Pullamsetti, J. Kaur Bains, N. Sentuerk Cetin, Ingrid Grummt, B. Pflueger-Mueller, Mario Looso, Jens Preussner, Flávia Rezende, Teodora Ribarska, Stefan Guenther, Sandra Seredinski, Ilka Wittig, Matthias S. Leisegang, Chao-Chung Kuo
Publikováno v:
Nature Communications 13, 6563 (2022). doi:10.1038/s41467-022-34252-2
nature communications 13, 6563 (2022). doi:10.1038/s41467-022-34252-2
Published by Nature Publishing Group UK, [London]
Published by Nature Publishing Group UK, [London]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845dc6d54b825c2bc0691f74daa010c5
https://publications.rwth-aachen.de/record/862054
https://publications.rwth-aachen.de/record/862054
Autor:
Andreas Weigert, Xiang Zheng, Alina Nenzel, Kati Turkowski, Stefan Günther, Elisabeth Strack, Evelyn Sirait-Fischer, Eiman Elwakeel, Ivan M. Kur, Vandana S. Nikam, Chanil Valasarajan, Hauke Winter, Alexander Wissgott, Robert Voswinkel, Friedrich Grimminger, Bernhard Brüne, Werner Seeger, Soni Savai Pullamsetti, Rajkumar Savai
Publikováno v:
Nature communications. 13(1)
Fibrocytes are bone marrow–derived monocytic cells implicated in wound healing. Here, we identify their role in lung cancer progression/ metastasis. Selective manipulation of fibrocytes in mouse lung tumor models documents the central role of fibro
Autor:
Astrid Wietelmann, Soni Savai Pullamsetti, Chanil Valasarajan, Christian Muecke, Swati Dabral, Friedrich Grimminger, Thomas Muley, Werner Seeger, Christos Samakovlis, Gregg L. Semenza, Rajkumar Savai, Norbert Weissmann, Mario Schmoranzer, Michael Meister, Tamina Seeger-Nukpezah
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Nature Communications
Nature Communications
Hypoxia signaling plays a major role in non-malignant and malignant hyperproliferative diseases. Pulmonary hypertension (PH), a hypoxia-driven vascular disease, is characterized by a glycolytic switch similar to the Warburg effect in cancer. Ras asso
Autor:
Oliver Rossbach, Florian Bischoff, Soni Savai Pullamsetti, Werner Seeger, Stefanie Dimmeler, Christoph M. Zehendner, Shemsi Demolli, Chanil Valasarajan, Tyler Weirick, Roxana Wasnick, Simone F. Glaser, Andreas M. Zeiher, Jes-Niels Boeckel, David John, Vinicio A. de Jesus Perez, Astrid Werner, Wei Chen, Ke Yuan, Katharina M. Michalik, Nicolas Jaé, Shizuka Uchida, Fatemeh Khassafi, Andreas Guenther
Publikováno v:
Am J Respir Crit Care Med.
American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine
Rationale: Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse biological functions. Their role in pulmonary arterial hypertension (PAH) remains to be explored. Objectives: To elucidate the role of TYKRIL (tyrosine kinase re
Autor:
Konstantinos Stellos, Ralph T. Schermuly, Stefan Günther, Matthias S. Leisegang, Yuliya Ponomareva, Ilka Wittig, Carsten Künne, Ralf P. Brandes, Lars Maegdefessel, Patrick Hofmann, Christian Fork, Franziska Moll, Stefanie Dimmeler, Jeremy Epah, Reinier A. Boon, Jiong Hu, Chanil Valasarajan, Jens Preussner, Shizuka Uchida, Florian Richter, Mario Looso, Juliana Heidler, Thomas M. Freiman, Francis J. Miller, Soni Savai Pullamsetti, Karl H. Plate, Ivana Josipovic, Matthew J. Miller, Kavi Devraj, Norbert Weissmann, Michel Mittelbronn
Publikováno v:
Leisegang, M S, Fork, C, Josipovic, I, Richter, F M, Preussner, J, Hu, J, Miller, M J, Epah, J, Hofmann, P, Günther, S, Moll, F, Valasarajan, C, Heidler, J, Ponomareva, Y, Freiman, T M, Maegdefessel, L, Plate, K H, Mittelbronn, M, Uchida, S, Künne, C, Stellos, K, Schermuly, R T, Weissmann, N, Devraj, K, Wittig, I, Boon, R A, Dimmeler, S, Pullamsetti, S S, Looso, M, Miller, F J & Brandes, R P 2017, ' Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function ', Circulation, vol. 136, no. 1, pp. 65-79 . https://doi.org/10.1161/CIRCULATIONAHA.116.026991
Circulation, 136(1), 65-79. Lippincott Williams and Wilkins
Circulation, 136(1), 65-79. Lippincott Williams and Wilkins
Background: The angiogenic function of endothelial cells is regulated by numerous mechanisms, but the impact of long noncoding RNAs (lncRNAs) has hardly been studied. We set out to identify novel and functionally important endothelial lncRNAs. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0165eb58c767c08185c6762c23b185cc
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/43910
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/43910