Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Chani J. Hodonsky"'
Autor:
Chani J. Hodonsky, Adam W. Turner, Mohammad Daud Khan, Nelson B. Barrientos, Ruben Methorst, Lijiang Ma, Nicolas G. Lopez, Jose Verdezoto Mosquera, Gaëlle Auguste, Emily Farber, Wei Feng Ma, Doris Wong, Suna Onengut-Gumuscu, Maryam Kavousi, Patricia A. Peyser, Sander W. van der Laan, Nicholas J. Leeper, Jason C. Kovacic, Johan L.M. Björkegren, Clint L. Miller
Publikováno v:
Cell Genomics, Vol 4, Iss 1, Pp 100465- (2024)
Summary: Genome-wide association studies (GWASs) have identified hundreds of risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in GWASs, and the causal gene-regulatory mechanisms of these risk loci du
Externí odkaz:
https://doaj.org/article/edb54c8409764f119fe134388ec9ee15
Autor:
Jose Verdezoto Mosquera, Gaëlle Auguste, Doris Wong, Adam W. Turner, Chani J. Hodonsky, Astrid Catalina Alvarez-Yela, Yipei Song, Qi Cheng, Christian L. Lino Cardenas, Konstantinos Theofilatos, Maxime Bos, Maryam Kavousi, Patricia A. Peyser, Manuel Mayr, Jason C. Kovacic, Johan L.M. Björkegren, Rajeev Malhotra, P. Todd Stukenberg, Aloke V. Finn, Sander W. van der Laan, Chongzhi Zang, Nathan C. Sheffield, Clint L. Miller
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113380- (2023)
Summary: Coronary artery disease (CAD) is characterized by atherosclerotic plaque formation in the arterial wall. CAD progression involves complex interactions and phenotypic plasticity among vascular and immune cell lineages. Single-cell RNA-seq (sc
Externí odkaz:
https://doaj.org/article/f36322cc9dc74a4986bc713522f0f6e4
Autor:
Wei Feng Ma, Adam W. Turner, Christina Gancayco, Doris Wong, Yipei Song, Jose Verdezoto Mosquera, Gaëlle Auguste, Chani J. Hodonsky, Ajay Prabhakar, H. Atakan Ekiz, Sander W. van der Laan, Clint L. Miller
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Single-cell RNA-seq (scRNA-seq) is a powerful genomics technology to interrogate the cellular composition and behaviors of complex systems. While the number of scRNA-seq datasets and available computational analysis tools have grown exponentially, th
Externí odkaz:
https://doaj.org/article/89d0a6900b2d4ccca5ec751d0190c2cc
Autor:
Maria Elishaev, Chani J. Hodonsky, Saikat Kumar B. Ghosh, Aloke V. Finn, Moritz von Scheidt, Ying Wang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Over the last few years, new high-throughput biotechnologies and bioinformatic methods are revolutionizing our way of deep profiling tissue specimens at the molecular levels. These recent innovations provide opportunities to advance our understanding
Externí odkaz:
https://doaj.org/article/80f9881c55984366ae72f1bed394d48b
Autor:
Yao Hu, Stephanie A. Bien, Katherine K. Nishimura, Jeffrey Haessler, Chani J. Hodonsky, Antoine R. Baldassari, Heather M. Highland, Zhe Wang, Michael Preuss, Colleen M. Sitlani, Genevieve L. Wojcik, Ran Tao, Mariaelisa Graff, Laura M. Huckins, Quan Sun, Ming-Huei Chen, Abdou Mousas, Paul L. Auer, Guillaume Lettre, the Blood Cell Consortium, Charles Kooperberg
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background Circulating white blood cell and platelet traits are clinically linked to various disease outcomes and differ across individuals and ancestry groups. Genetic factors play an important role in determining these traits and many loci
Externí odkaz:
https://doaj.org/article/492ab9ab7f354c8e890b3502d9d97085
Autor:
Chani J. Hodonsky, Antoine R. Baldassari, Stephanie A. Bien, Laura M. Raffield, Heather M. Highland, Colleen M. Sitlani, Genevieve L. Wojcik, Ran Tao, Marielisa Graff, Weihong Tang, Bharat Thyagarajan, Steve Buyske, Myriam Fornage, Lucia A. Hindorff, Yun Li, Danyu Lin, Alex P. Reiner, Kari E. North, Ruth J. F. Loos, Charles Kooperberg, Christy L. Avery
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of RBC trait GWAS have been performed in European- or East Asian-ancestry population
Externí odkaz:
https://doaj.org/article/6ff5554a9a9846dab897a9bbaf6c30b9
Autor:
Yao Hu, Stephanie A. Bien, Katherine K. Nishimura, Jeffrey Haessler, Chani J. Hodonsky, Antoine R. Baldassari, Heather M. Highland, Zhe Wang, Michael Preuss, Colleen M. Sitlani, Genevieve L. Wojcik, Ran Tao, Mariaelisa Graff, Laura M. Huckins, Quan Sun, Ming-Huei Chen, Abdou Mousas, Paul L. Auer, Guillaume Lettre, the Blood Cell Consortium, Weihong Tang, Lihong Qi, Bharat Thyagarajan, Steve Buyske, Myriam Fornage, Lucia A. Hindorff, Yun Li, Danyu Lin, Alexander P. Reiner, Kari E. North, Ruth J. F. Loos, Laura M. Raffield, Ulrike Peters, Christy L. Avery, Charles Kooperberg
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/7a12d213c8dd412db875b5fa8b1209a6
Autor:
Jia Wen, Munan Xie, Bryce Rowland, Jonathan D. Rosen, Quan Sun, Jiawen Chen, Amanda L. Tapia, Huijun Qian, Madeline H. Kowalski, Yue Shan, Kristin L. Young, Marielisa Graff, Maria Argos, Christy L. Avery, Stephanie A. Bien, Steve Buyske, Jie Yin, Hélène Choquet, Myriam Fornage, Chani J. Hodonsky, Eric Jorgenson, Charles Kooperberg, Ruth J. F. Loos, Yongmei Liu, Jee-Young Moon, Kari E. North, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Wei Zhao, Lulu Shang, Tao Wang, Xiang Zhou, Alexander P. Reiner, Laura M. Raffield, Yun Li
Publikováno v:
Genes, Vol 12, Iss 7, p 1049 (2021)
Background: Thousands of genetic variants have been associated with hematological traits, though target genes remain unknown at most loci. Moreover, limited analyses have been conducted in African ancestry and Hispanic/Latino populations; hematologic
Externí odkaz:
https://doaj.org/article/d6fe4cbb94a14a6c8280a231d93bb626
Autor:
Michal Mokry, Arjan Boltjes, Lotte Slenders, Gemma Bel-Bordes, Kai Cui, Eli Brouwer, Joost M. Mekke, Marie A. C. Depuydt, Nathalie Timmerman, Farahnaz Waissi, Maarten C. Verwer, Adam W. Turner, Mohammad Daud Khan, Chani J. Hodonsky, Ernest Diez Benavente, Robin J. G. Hartman, Noortje A. M. van den Dungen, Nico Lansu, Emilia Nagyova, Koen H. M. Prange, Jason C. Kovacic, Johan L. M. Björkegren, Eleftherios Pavlos, Evangelos Andreakos, Heribert Schunkert, Gary K. Owens, Claudia Monaco, Aloke V. Finn, Renu Virmani, Nicholas J. Leeper, Menno P. J. de Winther, Johan Kuiper, Gert J. de Borst, Erik S. G. Stroes, Mete Civelek, Dominique P. V. de Kleijn, Hester M. den Ruijter, Folkert W. Asselbergs, Sander W. van der Laan, Clint L. Miller, Gerard Pasterkamp
Publikováno v:
Nature Cardiovascular Research. 1:1140-1155
Autor:
Madeline H Kowalski, Huijun Qian, Ziyi Hou, Jonathan D Rosen, Amanda L Tapia, Yue Shan, Deepti Jain, Maria Argos, Donna K Arnett, Christy Avery, Kathleen C Barnes, Lewis C Becker, Stephanie A Bien, Joshua C Bis, John Blangero, Eric Boerwinkle, Donald W Bowden, Steve Buyske, Jianwen Cai, Michael H Cho, Seung Hoan Choi, Hélène Choquet, L Adrienne Cupples, Mary Cushman, Michelle Daya, Paul S de Vries, Patrick T Ellinor, Nauder Faraday, Myriam Fornage, Stacey Gabriel, Santhi K Ganesh, Misa Graff, Namrata Gupta, Jiang He, Susan R Heckbert, Bertha Hidalgo, Chani J Hodonsky, Marguerite R Irvin, Andrew D Johnson, Eric Jorgenson, Robert Kaplan, Sharon L R Kardia, Tanika N Kelly, Charles Kooperberg, Jessica A Lasky-Su, Ruth J F Loos, Steven A Lubitz, Rasika A Mathias, Caitlin P McHugh, Courtney Montgomery, Jee-Young Moon, Alanna C Morrison, Nicholette D Palmer, Nathan Pankratz, George J Papanicolaou, Juan M Peralta, Patricia A Peyser, Stephen S Rich, Jerome I Rotter, Edwin K Silverman, Jennifer A Smith, Nicholas L Smith, Kent D Taylor, Timothy A Thornton, Hemant K Tiwari, Russell P Tracy, Tao Wang, Scott T Weiss, Lu-Chen Weng, Kerri L Wiggins, James G Wilson, Lisa R Yanek, Sebastian Zöllner, Kari E North, Paul L Auer, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology & Hemostasis Working Group, Laura M Raffield, Alexander P Reiner, Yun Li
Publikováno v:
PLoS Genetics, Vol 15, Iss 12, p e1008500 (2019)
Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, and genetic studies of populations of Hispanic/Latino and African ancestry are limited. In addition, these populations have more com
Externí odkaz:
https://doaj.org/article/e2012563f33841c88441169fde0c6cd0