Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Changyu Jiang"'
Autor:
Michele Yeo, Yong Chen, Changyu Jiang, Gang Chen, Kaiyuan Wang, Sharat Chandra, Andrey Bortsov, Maria Lioudyno, Qian Zeng, Peng Wang, Zilong Wang, Jorge Busciglio, Ru-Rong Ji, Wolfgang Liedtke
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Lack of expression and function of chloride ion-extruding transporter KCC2 in central neurons, a consequence of various forms of neural injury, is strongly suggested to contribute to chronic pain. Here the authors identify from a screen of cancer dru
Externí odkaz:
https://doaj.org/article/1d93de373a484a6bb01f0fc42be69ad1
Autor:
Kaiyuan Wang, Christopher R. Donnelly, Changyu Jiang, Yihan Liao, Xin Luo, Xueshu Tao, Sangsu Bang, Aidan McGinnis, Michael Lee, Matthew J. Hilton, Ru-Rong Ji
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
There is an unmet clinical need to develop therapies to alleviate metastatic bone pain, frequently observed in patients with advanced cancers. Here, using mouse models of bone cancer pain, the authors show that STING agonists not only suppress bone c
Externí odkaz:
https://doaj.org/article/d82ef968c2e84210ad88047195778682
Autor:
Jing Xu, Shinan Wu, Junfei Wang, Jianmei Wang, Yi Yan, Mengye Zhu, Daying Zhang, Changyu Jiang, Tao Liu
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-17 (2021)
Abstract Background Nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2)-induced oxidative stress, including the production of reactive oxygen species (ROS) and hydrogen peroxide, plays a pivotal role in neuropathic pain. Although the activat
Externí odkaz:
https://doaj.org/article/6f8e762aec754eed860db7998c50a682
Autor:
Xiyuan Ba, Chenqiu Ran, Wenjun Guo, Jing Guo, Qian Zeng, Tao Liu, Wuping Sun, Lizu Xiao, Donglin Xiong, Yelan Huang, Changyu Jiang, Yue Hao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Oxytocin (OT) and its receptor are promising targets for the treatment and prevention of the neuropathic pain. In the present study, we compared the effects of a single and continuous intrathecal infusion of OT on nerve injury-induced neuropathic pai
Externí odkaz:
https://doaj.org/article/45068f546c084332821a540734138299
Autor:
Jiabin Huang, Yongxin Li, Huijun Xie, Shaomin Yang, Changyu Jiang, Wuping Sun, Disen Li, Yuliang Liao, Xiyuan Ba, Lizu Xiao
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Objective: Neuroimaging studies on neuropathic pain have discovered abnormalities in brain structure and function. However, the brain pattern changes from herpes zoster (HZ) to postherpetic neuralgia (PHN) remain unclear. The present study aimed to c
Externí odkaz:
https://doaj.org/article/7602ed43903a48bd9dcf585c8e69ded6
Autor:
Changyu Jiang, Zilong Wang, Christopher R. Donnelly, Kaiyuan Wang, Amanda S. Andriessen, Xueshu Tao, Megumi Matsuda, Junli Zhao, Ru-Rong Ji
Publikováno v:
iScience, Vol 23, Iss 10, Pp 101570- (2020)
Summary: The immune checkpoint inhibitor programmed cell death protein 1 (PD-1) plays a critical role in immune regulation. Recent studies have demonstrated functional PD-1 expression in peripheral sensory neurons, which contributes to neuronal excit
Externí odkaz:
https://doaj.org/article/76f0639f4d134c209b18c1d83305e22d
Autor:
Wuping Sun, Zhijian Yu, Shaomin Yang, Changyu Jiang, Yanbo Kou, Lizu Xiao, Shuo Tang, Tao Zhu
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
BackgroundObesity is characterized by increased adipose tissue mass that results from increased fat cell size (hypertrophy) and number (hyperplasia). The molecular mechanisms that govern the regulation and differentiation of adipocytes play a critica
Externí odkaz:
https://doaj.org/article/912f8c1d043c461e9ad7c561c031bc4e
Autor:
Jing Guo, Xiyuan Ba, Megumi Matsuda, Pengfei Wei, Changyu Jiang, Wuping Sun, Lizu Xiao, Donglin Xiong, Xiang Liao, Yue Hao
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Oxytocin (OT), a neuropeptide involved in the regulation of complex social and sexual behavior in mammals, has been proposed as a treatment for a number of psychiatric disorders including pain. It has been well documented that central administration
Externí odkaz:
https://doaj.org/article/06605e3dfb1b4d4eb82c6b0d47ae0ce8
Autor:
Santosh K. Mishra, Joshua J. Wheeler, Saumitra Pitake, Huiping Ding, Changyu Jiang, Tomoki Fukuyama, Judy S. Paps, Patrick Ralph, Jacob Coyne, Michelle Parkington, Jennifer DeBrecht, Lauren C. Ehrhardt-Humbert, Glenn P. Cruse, Wolfgang Bäumer, Ru-Rong Ji, Mei-Chuan Ko, Thierry Olivry
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Chronic allergic itch is a common symptom affecting millions of people and animals, but its pathogenesis is not fully explained. Herein, we show that periostin, abundantly expressed in the skin of patients with atopic dermatitis (AD), induce
Externí odkaz:
https://doaj.org/article/d9a4e1d17b0e47259c72065d38768e71
Autor:
Jing Wu, Sicong Peng, Linghui Xiao, Xiaoe Cheng, Haixia Kuang, Mengye Zhu, Daying Zhang, Changyu Jiang, Tao Liu
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Spinal lamina II (substantia gelatinosa, SG) neurons integrate nociceptive information from the primary afferents and are classified according to electrophysiological (tonic firing, delayed firing, single spike, initial burst, phasic firing, gap firi
Externí odkaz:
https://doaj.org/article/bdb2a59e6d754b26b0f8f6273f227519