Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Changyong Wei"'
Autor:
Richa Bajpai, Aditi Sharma, Abhinav Achreja, Claudia L. Edgar, Changyong Wei, Arusha A. Siddiqa, Vikas A. Gupta, Shannon M. Matulis, Samuel K. McBrayer, Anjali Mittal, Manali Rupji, Benjamin G. Barwick, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise, Deepak Nagrath, Mala Shanmugam
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Venetoclax monotherapy is effective in 40% of t(11:14) positive multiple myeloma (MM). Here, the authors show that electron transport chain complex I (CI) and complex II (CII) activity predict MM sensitivity to venetoclax, and inhibition of CI with I
Externí odkaz:
https://doaj.org/article/ab542c51a366402d8b83cd98c687f243
Autor:
Lei Huang, Ramireddy Bommireddy, Luis E Munoz, Rohini N Guin, Changyong Wei, Amanda Ruggieri, Ashwathi P Menon, Xiaoxian Li, Mala Shanmugam, Taofeek K Owonikoko, Suresh S Ramalingam, Periasamy Selvaraj
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0254125 (2021)
Imaging techniques based on fluorescence and bioluminescence have been important tools in visualizing tumor progression and studying the effect of drugs and immunotherapies on tumor immune microenvironment in animal models of cancer. However, transge
Externí odkaz:
https://doaj.org/article/dc6e930ff2a44d15a2ac8e0dd7a119d8
Autor:
Ding Ye, Xiaosi Wang, Changyong Wei, Mudan He, Houpeng Wang, Yanwu Wang, Zuoyan Zhu, Yonghua Sun
Publikováno v:
PLoS Genetics, Vol 15, Iss 9, p e1008306 (2019)
During vertebrate early embryogenesis, the ventral development is directed by the ventral-to-dorsal activity gradient of the bone morphogenetic protein (BMP) signaling. As secreted ligands, the extracellular traffic of BMP has been extensively studie
Externí odkaz:
https://doaj.org/article/a49ec30e315046f7b617c2c42e1d0f46
Autor:
Mala Shanmugam, Steven T. Rosen, Noopur S. Raje, Jennifer E. Koblinski, Seema Singhal, Changyong Wei, Irawati Kandela, Kehinde U.A. Adekola, Maylyn Martinez, Richa Bajpai, Sevim Dalva-Aydemir
Supplementary Figure 1. Combination of ritonavir and metformin is growth inhibitory in solid tumors such as breast and ovarian cancers. Breast (A) ovarian (B) cancer cell lines were cultured in the presence of 20µM ritonavir, and/or increasing conce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba36362d2e2756a36304cca039b5d6e4
https://doi.org/10.1158/1078-0432.22460096
https://doi.org/10.1158/1078-0432.22460096
Autor:
Mala Shanmugam, Steven T. Rosen, Noopur S. Raje, Jennifer E. Koblinski, Seema Singhal, Changyong Wei, Irawati Kandela, Kehinde U.A. Adekola, Maylyn Martinez, Richa Bajpai, Sevim Dalva-Aydemir
Purpose: We have previously demonstrated that ritonavir targeting of glycolysis is growth inhibitory and cytotoxic in a subset of multiple myeloma cells. In this study, our objective was to investigate the metabolic basis of resistance to ritonavir a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::381945671800d9f531461414ff825120
https://doi.org/10.1158/1078-0432.c.6524399.v1
https://doi.org/10.1158/1078-0432.c.6524399.v1
Autor:
Benjamin G. Barwick, Arusha A. Siddiqa, Anjali Mittal, Samuel K. McBrayer, Changyong Wei, Mala Shanmugam, Deepak Nagrath, Aditi Sharma, Ajay K. Nooka, Richa Bajpai, Abhinav Achreja, Claudia L. Edgar, Vikas Gupta, Sagar Lonial, Manali Rupji, Shannon M. Matulis, Lawrence H. Boise
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
The BCL-2 antagonist venetoclax is highly effective in multiple myeloma (MM) patients exhibiting the 11;14 translocation, the mechanistic basis of which is unknown. In evaluating cellular energetics and metabolism of t(11;14) and non-t(11;14) MM, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5d9e6fffd24eed6ab538cbd5ccac4b
http://link.springer.com/article/10.1038/s41467-020-15051-z
http://link.springer.com/article/10.1038/s41467-020-15051-z
Autor:
Hao Zhang, Jicheng Xing, Bingya Yang, Jingwei Song, Hongzhi Sun, Yenan Zhang, Zhi-hui Yang, Zhen-nan Yu, Tuo-ye Xu, Changyong Wei, Yan-song Zhang, Min Hou, Zhipeng Xu, Minjun Ji
Publikováno v:
International Journal of Biological Sciences
Glioma is one of the most common brain tumors, suggesting the importance of investigating the molecular mechanism of gliomas. We studied the roles of Ribonucleotide Reductase Regulatory Subunit M2 (RRM2) in glioma. Expressions of RRM2 are higher in g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e0173cacc7a3fc796ee139ea152a65
https://doi.org/10.7150/ijbs.30114
https://doi.org/10.7150/ijbs.30114
Autor:
Xiaoxian Li, Ashwathi P. Menon, Mala Shanmugam, Suresh S. Ramalingam, Taofeek K. Owonikoko, Lei Huang, Ramireddy Bommireddy, Periasamy Selvaraj, Rohini N. Guin, Amanda Ruggieri, Changyong Wei, Luis E. Munoz
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0254125 (2021)
PLoS ONE
PLoS ONE
Imaging techniques based on fluorescence and bioluminescence have been important tools in visualizing tumor progression and studying the effect of drugs and immunotherapies on tumor immune microenvironment in animal models of cancer. However, transge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37f45fe9dfb1f8371309e2b1d8845c7
https://doaj.org/article/dc6e930ff2a44d15a2ac8e0dd7a119d8
https://doaj.org/article/dc6e930ff2a44d15a2ac8e0dd7a119d8
Autor:
Changyong Wei, Jun Fan, Huanhuan Huang, Zhen Shu, Li Yu, Zhen Li, Qi Qi, Guo Chen, Dongping Wei, Yan Chen, Qi Feng, Changliang Shan, Hao Sheng, Guangqiang Li, Zhihui Wu, Ling Tian, Zhongqiu Xie, Shuang Peng, Xiaobo Li
Publikováno v:
Oncogene. 39(35)
Ribonucleotide reductase (RNR) catalyzes the rate-limiting step of de novo synthesis of deoxyribonucleotide triphosphates (dNTPs) building blocks for DNA synthesis, and is a well-recognized target for cancer therapy. RNR is a heterotetramer consistin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8ed59483bed381789a393aff7d2567
https://pubmed.ncbi.nlm.nih.gov/32712628
https://pubmed.ncbi.nlm.nih.gov/32712628
Autor:
Wei Zhou, Darius Mahboubi, L. J. Burton, Aditi Sharma, Jessica Konen, R. J. Peterson, Mala Shanmugam, Janna K. Mouw, Adam I. Marcus, Rachel Commander, Yuhong Du, Changyong Wei, Haian Fu, Emily R. Summerbell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Phenotypic heterogeneity exists within collectively invading packs of tumor cells, suggesting that cellular subtypes cooperate to drive invasion and metastasis. Here, we take a chemical biology approach to probe cell:cell cooperation within the colle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf48a0697e878a1fbdf81b80301df65e
https://doi.org/10.1038/s41467-020-15219-7
https://doi.org/10.1038/s41467-020-15219-7