Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Changyi Ji"'
Autor:
Yixiang Jiang, Yan Lin, Amber M. Tetlow, Ruimin Pan, Changyi Ji, Xiang-Peng Kong, Erin E. Congdon, Einar M. Sigurdsson
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-24 (2024)
Abstract Synucleinopathies are a group of neurodegenerative diseases characterized by the accumulation of α-synuclein (α-syn) in the brain, leading to motor and neuropsychiatric symptoms. Currently, there are no known cures for synucleinopathies, a
Externí odkaz:
https://doaj.org/article/a84e6645814e4c4b8b53a044a5b7e94a
Autor:
Qian Wu, Yang Bai, Wei Li, Erin E. Congdon, Wenke Liu, Yan Lin, Changyi Ji, Wen-Biao Gan, Einar M. Sigurdsson
Publikováno v:
Neurobiology of Disease, Vol 147, Iss , Pp 105165- (2021)
Perturbed neuronal Ca2+ homeostasis is implicated in Alzheimer's disease, which has primarily been demonstrated in mice with amyloid-β deposits but to a lesser and more variable extent in tauopathy models.In this study, we injected AAV to express Ca
Externí odkaz:
https://doaj.org/article/e5c4ccb26c1843cf9df2959327faf020
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Human Bestrophin1 (hBest1), a calcium-activated chloride channel in retinal pigment epithelium (RPE), is essential for retina physiology. Using electrophysiological and structural approaches, the authors uncover an ATP-dependent activation mechanism
Externí odkaz:
https://doaj.org/article/d2fbb4e9fd0d4e02a648786cc5e5354a
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Changyi Ji, Einar M. Sigurdsson
Publikováno v:
Drugs
Tau immunotherapies have advanced from proof-of-concept studies to over a dozen clinical trials for Alzheimer's disease (AD) and other tauopathies. Mechanistic studies in animal and culture models have provided valuable insight into how these therapi
Autor:
Massimo Aureli, Emma Veronica Carsana, Yoshinori Endo, Evandro F. Fang, Alexandra Gilbert, Douglas R. Green, Shinji Hadano, Tadanori Hamano, Nobutaka Hattori, Bradlee L. Heckmann, Yoshio Ikeda, Atsushi Iwata, Changyi Ji, Gail V.W. Johnson, Tetsushi Kataura, Heng Lin, Nicoletta Loberto, Giulia Lunghi, Kouki Makioka, Tatsuo Mano, Yasuo Miki, Yumiko Motoi, Tatsuro Mutoh, Koichi Okamoto, Kenjiro Ono, Asako Otomo, Thale D.J.H. Patrick-Brown, Shinji Saiki, Yukiko Sasazawa, Masayuki Sato, Tomas Schmauck-Medina, Shotaro Shimonaka, Sandro Sonnino, Kazuma Sugie, Azusa Sugimoto, Masamitsu Takatama, Kunikazu Tanji, Mohammad Nasir Uddin, Koichi Wakabayashi, Tsuneo Yamazaki, Shi-qi Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c834441206db97575e773ed010419f00
https://doi.org/10.1016/b978-0-323-89906-2.09992-5
https://doi.org/10.1016/b978-0-323-89906-2.09992-5
Autor:
Tingting Yang, Nancy Ward, Alec Kittredge, Shoudeng Chen, Yu Zhang, Changyi Ji, Yohta Fukuda, Austin Hopiavuori
Publikováno v:
Communications Biology, Vol 2, Iss 1, Pp 1-13 (2019)
Communications Biology
Communications Biology
Mutations of human BEST1, encoding a Ca2+-activated Cl− channel (hBest1), cause macular degenerative disorders. Best1 homolog structures reveal an evolutionarily conserved channel architecture highlighted by two landmark restrictions (named the “
Autor:
Gregor Cvetojevic, Peter Girardi, Maoping Tang, Daniel Chen, Gail V.W. Johnson, Heng Lin, Changyi Ji, Shon A. Koren
Publikováno v:
Biol Psychiatry
Declining proteostasis with aging contributes to increased susceptibility to neurodegenerative diseases, including Alzheimer's disease (AD). Emerging studies implicate impairment of the endosome-lysosome pathway as a significant factor in the pathoge
Autor:
Heng Lin, Maoping Tang, Changyi Ji, Peter Girardi, Gregor Cvetojevic, Yunpo Chen, Shon A. Koren, Gail V. W. Johnson
BackgroundDeclining proteostasis with aging contributes to increased susceptibility to neurodegenerative diseases, including Alzheimer’s disease (AD). Emerging studies implicate impairment of the endosome-lysosome pathway as a significant factor in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::782d1215585bac96cec3b89360da4641
https://doi.org/10.1101/2021.01.25.428055
https://doi.org/10.1101/2021.01.25.428055