Výsledky vyhledávání - "Changxiong J. Guo"

Autor: Nathaniel S. Grabinski, Qin Liu, Changxiong J. Guo

Publikováno v: J Invest Dermatol

Itch is a universally experienced sensation, and chronic itch can be as diabolically debilitating as pain. Recent advances have not only identified the neuronal itch sensing circuitry, but also have uncovered the intricate interactions between skin a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c8b2cb41eed5c5a245f096743222d7
https://doi.org/10.1016/j.jid.2021.10.024

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Quantitative Characterization of the Neuropeptide Level Changes in Dorsal Horn and Dorsal Root Ganglia Regions of the Murine Itch Models

Autor: Eduardo A. De La Toba, Jessica Krebs, Ashley E. Lenhart, Changxiong J. Guo, Jonathan V. Sweedler, Krishna D. B. Anapindi, Qin Liu, Emily G. Tillmaand

Publikováno v: J Proteome Res

Chronic itch can be extremely devastating and, in many cases, difficult to treat. One challenge in treating itch disorders is the limited understanding of the multitude of chemical players involved in the communication of itch sensation from the peri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590f8e69c781c9d9222ff1a466b32379
https://doi.org/10.1021/acs.jproteome.9b00758

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IL-33 Signaling in Sensory Neurons Promotes Dry Skin Itch

Publikováno v: J Allergy Clin Immunol

Background Chronic pruritus, or itch, is common and debilitating, but the neuroimmune mechanisms that drive chronic itch are only starting to be elucidated. Recent studies demonstrate that the IL-33 receptor (IL-33R) is expressed by sensory neurons.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6fc16774cfd88db5ee2f11812d52786
https://europepmc.org/articles/PMC8934751/

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Kallikrein 7 Promotes Atopic Dermatitis-Associated Itch Independently of Skin Inflammation

Autor: Changxiong J. Guo, Madison R. Mack, Landon K. Oetjen, Anna M. Trier, Martha L. Council, Ana B. Pavel, Emma Guttman-Yassky, Brian S. Kim, Qin Liu

Publikováno v: J Invest Dermatol

Atopic dermatitis (AD) is a highly prevalent, itchy inflammatory skin disorder that is thought to arise from a combination of skin barrier defect and immune dysregulation. Kallikreins (KLK), a family of serine proteases with a diverse array of homeos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1678b67f3a96adbee653b29db8823c
https://doi.org/10.1016/j.jid.2019.10.022

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Enhanced itch elicited by capsaicin in a chronic itch model

Autor: Niuniu Yang, Ming Tang, Chan Zhu, Fengxian Li, Qian He, Tana Gegen, Qin Liu, Guang Yu, Hao Shi, Zhongli Wang, Yan Yang, Zongxiang Tang, Danyou Hu, Meijuan Chen, Changming Wang, Changxiong J. Guo

Publikováno v: Molecular Pain

Chronic itch (pruritus) is an important clinical problem. However, the underlying molecular basis has yet to be understood. The Transient Receptor Potential Vanilloid 1 channel is a heat-sensitive cation channel expressed in primary sensory neurons a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf6379a5818c86cc3eee1f2e49c3730
https://pubmed.ncbi.nlm.nih.gov/27118771

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Transient receptor potential A1 activation prolongs isoflurane induction latency and impairs respiratory function in mice

Autor: Qin Liu, Sarah M. Brown, Fengxian Li, Shiyuan Xu, Changxiong J. Guo, Cheng-Chiu Huang, Guang Yu

Publikováno v: Anesthesiology. 122(4)

Background: Isoflurane is a potent volatile anesthetic; however, it evokes airway irritation and neurogenic constriction through transient receptor potential (TRP) A1 channels and sensitizes TRPV1 channels, which colocalizes with TRPA1 in most of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7183588d72ba19929c632244f08e6c68
https://pubmed.ncbi.nlm.nih.gov/25646842

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Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch

Publikováno v: The Journal of Immunology. 198:63.3-63.3

Mammals have evolved neurophysiologic reflexes such as scratching to expel invading pathogens and noxious environmental factors. It is also well established that these responses are associated with chronic inflammatory diseases such as atopic dermati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d0f18ecc232ae826f487ad58c8f6505
https://doi.org/10.4049/jimmunol.198.supp.63.3

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