Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Changwon, Kho"'
Autor:
Changwon Kho
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Impaired myocardial Ca2+ cycling is a critical contributor to the development of heart failure (HF), causing changes in the contractile function and structure remodeling of the heart. Within cardiomyocytes, the regulation of sarcoplasmic reticulum (S
Externí odkaz:
https://doaj.org/article/d7f4138d0ec1456790fbbb0e76394196
Autor:
Przemek A. Gorski, Ahyoung Lee, Philyoung Lee, Jae Gyun Oh, Peter Vangheluwe, Kiyotake Ishikawa, Roger Hajjar, Changwon Kho
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3502 (2023)
Impaired calcium uptake resulting from reduced expression and activity of the cardiac sarco-endoplasmic reticulum Ca2+ ATPase (SERCA2a) is a hallmark of heart failure (HF). Recently, new mechanisms of SERCA2a regulation, including post-translational
Externí odkaz:
https://doaj.org/article/5466c28c47fb49998dc53e7c0a842f35
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7785 (2022)
Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD), which represent the range of dystrophinopathies, account for nearly 80% of muscle dystrophy. DMD and BMD result from the loss of a functional dystrophin protein, and the leading c
Externí odkaz:
https://doaj.org/article/b5438c1ab3064474a0ccd03b157fc620
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5053 (2022)
Post-translational modification (PTM) is an essential mechanism for enhancing the functional diversity of proteins and adjusting their signaling networks. The reversible conjugation of ubiquitin (Ub) and ubiquitin-like proteins (Ubls) to cellular pro
Externí odkaz:
https://doaj.org/article/d621ca519617454da1e4b64ebe86f1d0
Autor:
Jae-Ho Park, Changwon Kho
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10582 (2021)
In hearts, calcium (Ca2+) signaling is a crucial regulatory mechanism of muscle contraction and electrical signals that determine heart rhythm and control cell growth. Ca2+ signals must be tightly controlled for a healthy heart, and the impairment of
Externí odkaz:
https://doaj.org/article/6736cf366192403095227ceb5258daf1
Autor:
Delaine K. Ceholski, Irene C. Turnbull, Venu Pothula, Laura Lecce, Andrew A. Jarrah, Changwon Kho, Ahyoung Lee, Lahouaria Hadri, Kevin D. Costa, Roger J. Hajjar, Sima T. Tarzami
Publikováno v:
Stem Cell Research, Vol 23, Iss C, Pp 77-86 (2017)
CXCR4 and CXCR7 are prominent G protein-coupled receptors (GPCRs) for chemokine stromal cell-derived factor-1 (SDF-1/CXCL12). This study demonstrates that CXCR4 and CXCR7 induce differential effects during cardiac lineage differentiation and β-adren
Externí odkaz:
https://doaj.org/article/11c97dd43e1a49a3bf1a34fac3717cdb
Publikováno v:
The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology
In this study, we aimed to synthesize PAMAMG3 derivatives (PAMAMG3-KRRR and PAMAMG3-HKRRR), using KRRR peptides as a nuclear localization signal and introduced histidine residues into the KRRR-grafted PAMAMG3 for delivering a therapeutic, carcinoma c
Autor:
Changwon, Kho
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2573
MicroRNA (miRNA) is a small, non-coding RNA molecule (~22 nucleotides) that acts as a post-transcriptional gene regulator, primarily by inhibiting the translation of target mRNA transcripts or affecting cell mRNA stability. Since miRNAs are comprehen
Autor:
Bracy, Fertig, Jiayue, Ling, Edgar E, Nollet, Sara, Dobi, Tara, Busiau, Kiyotake, Ishikawa, Kelly, Yamada, Ahyoung, Lee, Changwon, Kho, Lauren, Wills, Amy J, Tibbo, Mark, Scott, Kirsten, Grant, Kenneth S, Campbell, Emma J, Birks, Niall, MacQuaide, Roger, Hajjar, Godfrey L, Smith, Jolanda, van der Velden, George S, Baillie
Publikováno v:
The FEBS journal. 289(20)
Post-translational modification of the myofilament protein troponin I by phosphorylation is known to trigger functional changes that support enhanced contraction and relaxation of the heart. We report for the first time that human troponin I can also
Publikováno v:
Journal of Cellular and Molecular Medicine
Extracellular vesicles (EVs) have recently emerged as an important carrier for various genetic materials including microRNAs (miRs). Growing evidences suggested that several miRs transported by EVs were particularly involved in modulating cardiac fun