Výsledky vyhledávání - "Changwen Ning"

Akademický článek

Immune inhibitory receptor-mediated immune response, metabolic adaptation, and clinical characterization in patients with COVID-19

Autor: Huaying An, Congrui Yan, Jun Ma, Jiayuan Gong, Fenghua Gao, Changwen Ning, Fei Wang, Meng Zhang, Baoyi Li, Yunqi Su, Pengyu Liu, Hanqi Wei, Xingwei Jiang, Qun Yu

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)

Abstract Immune inhibitory receptors (IRs) play a critical role in the regulation of immune responses to various respiratory viral infections. However, in coronavirus disease 2019 (COVID-19), the roles of these IRs in immune modulation, metabolic rep

Externí odkaz: https://doaj.org/article/7eac09f2c8bf4ac0a6512f8cfecd98ec

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Akademický článek

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

Autor: Carrie O’Connor, Adrianne Wallace-Povirk, Changwen Ning, Josephine Frühauf, Nian Tong, Aleem Gangjee, Larry H. Matherly, Zhanjun Hou

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract There are three major folate uptake systems in human tissues and tumors, including the reduced folate carrier (RFC), folate receptors (FRs) and proton-coupled folate transporter (PCFT). We studied the functional interrelationships among thes

Externí odkaz: https://doaj.org/article/dd3e87cff5634115a13acaae3166b8b6

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Akademický článek

Natural plant flavonoid apigenin directly disrupts Hsp90/Cdc37 complex and inhibits pancreatic cancer cell growth and migration

Autor: Jing He, Changwen Ning, Yu Wang, Tianfang Ma, He Huang, Yubin Ge, Jingbo Liu, Yiqun Jiang

Publikováno v: Journal of Functional Foods, Vol 18, Iss , Pp 10-21 (2015)

Apigenin is a common dietary plant flavonoid widely distributed in vegetables and fruits. It exhibits chemopreventive activity against various cancer cells. In this study, we demonstrated that apigenin directly blocked heat shock protein 90 (Hsp90) a

Externí odkaz: https://doaj.org/article/14587c485c044f19b55b942c44c322ce

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Supplementary Methods from Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

Supplementary Method Descriptions Molecular modeling and computational studies Enzyme expression and purification. In vitro enzymatic assays and Ki determinations In vivo efficacy trials with MIA PaCa-2 pancreatic cancer xenografts. Cytochrome c oxid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc08fe908fb7939bc9f8ad0ffe9cbc1
https://doi.org/10.1158/1535-7163.22505520

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Data from Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

Folate-dependent one-carbon (C1) metabolism is compartmentalized into the mitochondria and cytosol and supports cell growth through nucleotide and amino acid biosynthesis. Mitochondrial C1 metabolism, including serine hydroxymethyltransferase (SHMT)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4253307c713eb35fa04c2ec4fe8823be
https://doi.org/10.1158/1535-7163.c.6538104.v1

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Supplementary Data from Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy

Supplementary Figure S1 shows in vitro antiproliferative activity and targeted pathways of previously reported AICARFTase and GARFTase inhibitors. Supplementary Figure S2 shows docking of AGF291, AGF320, and AGF347 (along with 5-formyl-THF) in human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f58160726ffe67fe411c78ec2698b22
https://doi.org/10.1158/1535-7163.22505523.v1

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Folate transporter dynamics and therapy with classic and tumor-targeted antifolates

Autor: Adrianne Wallace-Povirk, Josephine Frühauf, Zhanjun Hou, Larry H. Matherly, Nian Tong, Carrie O'Connor, Changwen Ning, Aleem Gangjee

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports

There are three major folate uptake systems in human tissues and tumors, including the reduced folate carrier (RFC), folate receptors (FRs) and proton-coupled folate transporter (PCFT). We studied the functional interrelationships among these systems

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755062bebe4d8f4256feb0be735e1a72
https://doaj.org/article/dd3e87cff5634115a13acaae3166b8b6

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